An in-depth review: Unraveling the extraction, structure, bio-functionalities, target molecules, and applications of pectic polysaccharides

Pectic polysaccharides have long been a challenging subject of research in the field of macromolecular science, given their complex structures and wide range of biological effects. However, the extensive exploration of pectic polysaccharides has been limited due to the intricacy of their structures....

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Vydáno v:	Carbohydrate polymers Ročník 343; s. 122457
Hlavní autoři:	Pang, Yunrui, Peng, Zhigang, Ding, Kan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.11.2024
Témata:	Animals Applications Biofunctionalities domain drug development drugs Humans Pectic polysaccharide pectins Pectins - chemistry Pectins - isolation & purification polymers Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - pharmacology Signaling pathway Target molecules APP PI3K BMDC Gly RdRp RT-PCR Kdo STZ AceA GlcA SCs MIC qRT-PCR Pol LGG AS RBP4 ARE Cryo-EM 5-MC pro-IL-1 Dha HPE Pectic polysaccharide ATG5/8 ThT IBD cAMP M NOXA PPO GSK-3β BT Signaling pathway RDG W ISC TGF-β CA SR CC SWE GSSG AST CR TC TG Hap TJ Keap1 SCFAs GRAS ACHE DE BSLNs HEK293-APPsw cells DM IDE MyD88 UC HDL-C HIF1-α SARS-CoV-2 RNA-seq RG-I CHO/APPBACE1 UMAE F/B ratio JAK2 HBV UV Micro-CT HSV Gag MAPK BACE1 Gal Target molecules HT-29 PCR IgA Biofunctionalities LDL-C AFM HCT-116 IHC analysis MEK 1/2 Rha EGFR HCl EMSA HeLa cells IFV kHz GSH PGE2 Applications MOG PDX STAT3 APP-BP LMP FAK BCFAs FAS HG OTC ABTS, 2 HFD TNF DPPH, 2 CTX, Cy RG-II IL EAE p21Cip1 ADAM10 μg/mL MAE Smads XGA TOP HA-ADH UAE ERK sIgA GAGs PHB FOXO3 MBC Fuc Nrf2 UBC KD NLRP3 BMP MSN SOD AKT Xyl EV71 H&E staining NASH DAI SREBP-1c PC12 HIV CPC NEP FGFR1 ALP EDC JNK LR ALT 3CLpro MDA OHC MTT NF-κB BMPR IFN-γ WHC SPR iNOS Th17 BCL-XL DSS MR P-p38 LSR LMBR CCl4 NE ROS HUVECs ELISA TCR COX-2 BaCl2 MCL-1 Mw NOD1 PARP Gal-3 CETSA LDH TLR2/4 CD4/8/14/28/152 DDS LDL NHS INS-1 MMP-2/9 PTPN1 tBHP Aβ42 IPEC-J2 VEGF HMP GalA PE DMBA, 7 NK cell APG API Glc PO
ISSN:	0144-8617, 1879-1344, 1879-1344
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Popis
Shrnutí:	Pectic polysaccharides have long been a challenging subject of research in the field of macromolecular science, given their complex structures and wide range of biological effects. However, the extensive exploration of pectic polysaccharides has been limited due to the intricacy of their structures. In this comprehensive review, we aim to provide a thorough summary of the existing knowledge on pectic polysaccharides, with a particular focus on aspects such as classification, extraction methodologies, structural analysis, elucidation of biological activities, and exploration of target molecules and signaling pathways. By conducting a comprehensive analysis of existing literature and research achievements, we strive to establish a comprehensive and systematic framework that can serve as a reference and guide for further investigations into pectic polysaccharides. Furthermore, this review delves into the applications of pectic polysaccharides beyond their fundamental attributes and characteristics, exploring their potential in fields such as materials, food, and pharmaceuticals. We pay special attention to the promising opportunities for pectic polysaccharides in the pharmaceutical domain and provide an overview of related drug development research. The aim of this review is to facilitate a holistic understanding of pectic polysaccharides by incorporating multifaceted research, providing valuable insights for further in-depth investigations into this significant polymer. [Display omitted]
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0144-8617 1879-1344 1879-1344
DOI:	10.1016/j.carbpol.2024.122457