Ultrafast LC-MS/MS analysis of 5-hydroxyindoleacetic acid (5-HIAA) in serum

A very quick and easy LC-MS/MS analysis method for 5-HIAA (5-hydoxyindoleacetic acid) has been developed. The method was fully validated and proved to work well in a clinical setting. Precision at the upper reference limit 123 nmol/L was 3,3% CV. Accuracy ranged from 96% at low levels (50-100 nmol/L...

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Vydané v:	Scandinavian journal of clinical and laboratory investigation Ročník 81; číslo 5; s. 401 - 405
Hlavní autori:	Oxelbark, Joakim, Lövenhamn, Annicka
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Taylor & Francis 01.09.2021
Predmet:	5-Hydroxyindoleacetic acid Chromatography, Liquid - methods Humans Hydroxyindoleacetic Acid - blood Hydroxyindoleacetic Acid - chemistry Limit of Detection liquid chromatography mass spectrometry reference interval neuroendocrine tumor Reference Values serum Tandem Mass Spectrometry - methods 5-Hydroxyindoleacetic acid liquid chromatography mass spectrometry serum reference interval neuroendocrine tumor
ISSN:	0036-5513, 1502-7686, 1502-7686
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Popis
Shrnutí:	A very quick and easy LC-MS/MS analysis method for 5-HIAA (5-hydoxyindoleacetic acid) has been developed. The method was fully validated and proved to work well in a clinical setting. Precision at the upper reference limit 123 nmol/L was 3,3% CV. Accuracy ranged from 96% at low levels (50-100 nmol/L) to 99.7% at high levels (500 nmol/L). A previously reported reference interval of 35-123 nmol/L was confirmed as valid based on analysis of 40 samples from voluntary blood donors.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0036-5513 1502-7686 1502-7686
DOI:	10.1080/00365513.2021.1930141