Statistical challenges in assessing potential efficacy of complex interventions in pilot or feasibility studies

Early phase trials of complex interventions currently focus on assessing the feasibility of a large randomised control trial and on conducting pilot work. Assessing the efficacy of the proposed intervention is generally discouraged, due to concerns of underpowered hypothesis testing. In contrast, ea...

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Bibliographic Details

Published in:	Statistical methods in medical research Vol. 25; no. 3; pp. 997 - 1009
Main Authors:	Wilson, Duncan T, Walwyn, Rebecca Ea, Brown, Julia, Farrin, Amanda J, Brown, Sarah R
Format:	Journal Article
Language:	English
Published:	England 01.06.2016
Subjects:	Bayes Theorem Clinical Trials, Phase II as Topic - methods Feasibility Studies Humans Pilot Projects Research Design Sample Size feasibility phase II pilot sample size Complex interventions
ISSN:	1477-0334
Online Access:	Get more information
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