ORCHESTRA Delphi consensus: clinical management of SARS-CoV-2 infection in people with HIV

The interaction between HIV and COVID-19 resulted in a syndemic that showed an excess burden of disease for people with HIV (PWH). Four years of the COVID-19 pandemic have raised many unsolved questions about the optimal care of COVID-19 in PWH. We performed a study using a three-round Delphi method...

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Veröffentlicht in:Clinical microbiology and infection Jg. 31; H. 8S; S. S14
Hauptverfasser: Tavelli, Alessandro, Vergori, Alessandra, Cingolani, Antonella, Bai, Francesca, Azzini, Anna Maria, Hara, Gabriel Levy, Caponcello, Maria Giulia, Rinaldi, Matteo, Palacios-Baena, Zaira R, Gatti, Milo, Maccarrone, Gaia, Tacconelli, Evelina, Antinori, Andrea, Monforte, Antonella d'Arminio
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 01.06.2025
Schlagworte:
Consensus
COVID-19 - complications
COVID-19 - diagnosis
COVID-19 - epidemiology
COVID-19 - therapy
Delphi Technique
HIV Infections - complications
HIV Infections - epidemiology
Humans
SARS-CoV-2
COVID-19
SARS-CoV-2
HIV
Delphi
Consensus
ISSN:1469-0691, 1469-0691
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Zusammenfassung:The interaction between HIV and COVID-19 resulted in a syndemic that showed an excess burden of disease for people with HIV (PWH). Four years of the COVID-19 pandemic have raised many unsolved questions about the optimal care of COVID-19 in PWH. We performed a study using a three-round Delphi methodology involving a panel of physicians with expertise in HIV and COVID-19 infections. The main aim of the study was to provide recommendations on critical clinical issues of COVID-19 among PWH and to inform physicians and policy-makers for improving care and prevention of COVID-19 in PWH. A total of 27 questions were conceived, focusing on four main areas of interest in the management of COVID-19 in PWH; a panel of 34 experts in HIV and COVID-19 care expressed their level of agreement on each item. Questions that received agreement/disagreement ≥79.4% of panellists were identified and statements were generated accordingly. Consensus was reached on 19/27 items, resulting in 18 final statements. These statements addressed: (a) risk of COVID-19 progression to severe disease among PWH; (b) COVID-19 diagnostics and laboratory procedures; (c) early treatments with antivirals and/or monoclonal antibodies; (d) use of corticosteroids; (e) COVID-19 preventive strategies. This consensus's study guides infectious diseases physicians in making decisions regarding the care of PWH for COVID-19, where results from the scientific literature are limited or conflicting.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1469-0691
1469-0691
DOI:10.1016/j.cmi.2025.03.006