All-polysaccharide, self-healing, pH-sensitive, in situ-forming hydrogel of carboxymethyl chitosan and aldehyde-functionalized hydroxyethyl cellulose

In situ forming hydrogels are promising for biomedical applications, especially in drug delivery. The precursor solution can be injected at the target site, where it undergoes a sol-gel transition to afford a hydrogel. In this sense, the most significant characteristic of these hydrogels is fast gel...

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Bibliographic Details
Published in:Carbohydrate polymers Vol. 336; p. 122105
Main Authors: Quadrado, Rafael F.N., Zhai, Zhenghao, Zavadinack, Matheus, Klassen, Giseli, Iacomini, Marcello, Edgar, Kevin J., Fajardo, André R.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 15.07.2024
Subjects:
aldehydes
Aldehydes - chemistry
All-polysaccharide hydrogel
cellulose
Cellulose - analogs & derivatives
Cellulose - chemistry
chitosan
Chitosan - analogs & derivatives
Chitosan - chemistry
Drug Carriers - chemistry
Drug Liberation
drugs
Fast gelation
gelation
hydrogels
Hydrogels - chemistry
Hydrogen-Ion Concentration
oxidation
pH responsiveness
Polysaccharide derivatives
Polysaccharides - chemistry
Self-healing
stress relaxation
Fast gelation
Self-healing
pH responsiveness
All-polysaccharide hydrogel
Polysaccharide derivatives
ISSN:0144-8617, 1879-1344, 1879-1344
Online Access:Get full text
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Summary:In situ forming hydrogels are promising for biomedical applications, especially in drug delivery. The precursor solution can be injected at the target site, where it undergoes a sol-gel transition to afford a hydrogel. In this sense, the most significant characteristic of these hydrogels is fast gelation behavior after injection. This study describes an all-polysaccharide, rapidly in situ-forming hydrogel composed of carboxymethyl chitosan (CMCHT) and hydroxyethyl cellulose functionalized with aldehyde groups (HEC-Ald). The HEC-Ald was synthesized through acetal functionalization, followed by acid deprotection. This innovative approach avoids cleavage of pyran rings, as is inherent in the periodate oxidation approach, which is the most common method currently employed for adding aldehyde groups to polysaccharides. The resulting hydrogel exhibited fast stress relaxation, self-healing properties, and pH sensitivity, which allowed it to control the release of an encapsulated model drug in response to the medium pH. Based on the collected data, the HEC-Ald/CMCHT hydrogels show promise as pH-sensitive drug carriers. [Display omitted]
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ISSN:0144-8617
1879-1344
1879-1344
DOI:10.1016/j.carbpol.2024.122105