Genetics of Intracranial Aneurysms

Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a severe type of stroke which is, in part, driven by genetic variation. In the past 10 years, genetic studies of IA have boosted the number of known genetic risk factors and improved our understanding of the disease. In...

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Veröffentlicht in:Stroke (1970) Jg. 52; H. 9; S. 3004
Hauptverfasser: Bakker, Mark K, Ruigrok, Ynte M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.09.2021
Schlagworte:
Aneurysm, Ruptured - genetics
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study - methods
Humans
Intracranial Aneurysm - genetics
Risk Factors
Subarachnoid Hemorrhage - genetics
risk factors
genetics
intracranial aneurysm
humans
subarachnoid hemorrhage
ISSN:1524-4628, 1524-4628
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Zusammenfassung:Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a severe type of stroke which is, in part, driven by genetic variation. In the past 10 years, genetic studies of IA have boosted the number of known genetic risk factors and improved our understanding of the disease. In this review, we provide an overview of the current status of the field and highlight the latest findings of family based, sequencing, and genome-wide association studies. We further describe opportunities of genetic analyses for understanding, prevention, and treatment of the disease.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1524-4628
1524-4628
DOI:10.1161/STROKEAHA.120.032621