Effects of an acute D2-dopaminergic blockade on the somatosensory cortical responses in healthy humans: evidence from evoked magnetic fields

We tested the possible role of dopaminergic activity in the processing of somatosensory afferent information in healthy humans. Somatosensory evoked magnetic fields (SEFs) were recorded in seven subjects in response to left median nerve stimulation. SEFs were obtained in all subjects after oral admi...

Full description

Saved in:
Bibliographic Details
Published in:Neuroreport Vol. 14; no. 12; p. 1609
Main Authors: Huttunen, Juha, Kähkönen, Seppo, Kaakkola, Seppo, Ahveninen, Jyrki, Pekkonen, Eero
Format: Journal Article
Language:English
Published: England 26.08.2003
Subjects:
Adult
Cross-Over Studies
Dopamine Antagonists - pharmacology
Dopamine D2 Receptor Antagonists
Double-Blind Method
Electromagnetic Fields
Evoked Potentials, Somatosensory - drug effects
Evoked Potentials, Somatosensory - physiology
Female
Haloperidol - pharmacology
Humans
Male
Receptors, Dopamine D2 - physiology
Somatosensory Cortex - drug effects
Somatosensory Cortex - physiology
Statistics, Nonparametric
ISSN:0959-4965
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We tested the possible role of dopaminergic activity in the processing of somatosensory afferent information in healthy humans. Somatosensory evoked magnetic fields (SEFs) were recorded in seven subjects in response to left median nerve stimulation. SEFs were obtained in all subjects after oral administration of 2 mg haloperidol, an antagonist to dopaminergic D2 receptors, and placebo, which were given in a randomized, double-blind cross-over design. SEFs were analyzed using a multiple equivalent current dipole (ECD) model, with one dipole at the right primary somatosensory cortex (SI) and at both left and right secondary somatosensory cortices (SII). The earliest responses from SI, peaking at about 20 ms (N20m) and 35 ms (P35m), were not affected by haloperidol. A later deflection peaking at about 75 ms (P60m), however, was slightly reduced (p < 0.05). Responses arising from SII were not significantly changed. The results suggest that dopaminergic activity may be involved in modulating somatosensory processing after the initial stages of cortical activation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Undefined-3
ISSN:0959-4965
DOI:10.1097/00001756-200308260-00013