Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN‐derived networks and highlights causal links in Alzheimer's disease

Introduction This study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the amyloid/tau/neurodegeneration [AT(N)] framework, mild cognitive impairment (MCI) conversion to Alzheimer's disease (AD), and genetic risk for AD. Methods Us...

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Veröffentlicht in:	Alzheimer's & dementia Jg. 19; H. 8; S. 3350 - 3364
Hauptverfasser:	Shi, Liu, Xu, Jin, Green, Rebecca, Wretlind, Asger, Homann, Jan, Buckley, Noel J., Tijms, Betty M., Vos, Stephanie J. B., Lill, Christina M., Kate, Mara ten, Engelborghs, Sebastiaan, Sleegers, Kristel, Frisoni, Giovanni B., Wallin, Anders, Lleó, Alberto, Popp, Julius, Martinez‐Lage, Pablo, Streffer, Johannes, Barkhof, Frederik, Zetterberg, Henrik, Visser, Pieter Jelle, Lovestone, Simon, Bertram, Lars, Nevado‐Holgado, Alejo J., Proitsi, Petroula, Legido‐Quigley, Cristina
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.08.2023
Schlagworte:	Alzheimer's disease AT(N) framework Mendelian randomization multimodal biomarker multi‐omics polygenic risk score multi-omics Mendelian randomization AT(N) framework Alzheimer's disease multimodal biomarker polygenic risk score
ISSN:	1552-5260, 1552-5279, 1552-5279
Online-Zugang:	Volltext
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