Mortality due to Respiratory Syncytial Virus. Burden and Risk Factors

Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization and an important cause of death in infants in the developing world. The relative contribution of social, biologic, and clinical risk factors to RSV mortality in low-income regions is unclear. To determine the burden and...

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Veröffentlicht in:American journal of respiratory and critical care medicine Jg. 195; H. 1; S. 96 - 103
Hauptverfasser: Geoghegan, Sarah, Erviti, Anabella, Caballero, Mauricio T., Vallone, Fernando, Zanone, Stella M., Losada, Juan Ves, Bianchi, Alejandra, Acosta, Patricio L., Talarico, Laura B., Ferretti, Adrian, Grimaldi, Luciano Alva, Sancilio, Andrea, Dueñas, Karina, Sastre, Gustavo, Rodriguez, Andrea, Ferrero, Fernando, Barboza, Edgar, Gago, Guadalupe Fernández, Nocito, Celina, Flamenco, Edgardo, Perez, Alberto Rodriguez, Rebec, Beatriz, Ferolla, F. Martin, Libster, Romina, Karron, Ruth A., Bergel, Eduardo, Polack, Fernando P.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States American Thoracic Society 01.01.2017
Schlagworte:
Argentina - epidemiology
Cost of Illness
Cross-Sectional Studies
Female
Hospitalization - statistics & numerical data
Humans
Infant
Logistic Models
Male
Pneumothorax - etiology
Pneumothorax - mortality
Prospective Studies
Respiratory Syncytial Virus Infections - complications
Respiratory Syncytial Virus Infections - diagnosis
Respiratory Syncytial Virus Infections - mortality
Respiratory Syncytial Viruses
Risk Factors
Sepsis - etiology
Sepsis - mortality
Sex Factors
Socioeconomic Factors
bacterial superinfections
mortality
respiratory syncytial virus
pneumothorax
ISSN:1073-449X, 1535-4970
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Zusammenfassung:Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization and an important cause of death in infants in the developing world. The relative contribution of social, biologic, and clinical risk factors to RSV mortality in low-income regions is unclear. To determine the burden and risk factors for mortality due to RSV in a low-income population of 84,840 infants. This was a prospective, population-based, cross-sectional, multicenter study conducted between 2011 and 2013. Hospitalizations and deaths due to severe lower respiratory tract illness (LRTI) were recorded during the RSV season. All-cause hospital deaths and community deaths were monitored. Risk factors for respiratory failure (RF) and mortality due to RSV were assessed using a hierarchical, logistic regression model. A total of 2,588 (65.5%) infants with severe LRTI were infected with RSV. A total of 157 infants (148 postneonatal) experienced RF or died with RSV. RSV LRTI accounted for 57% fatal LRTI tested for the virus. A diagnosis of sepsis (odds ratio [OR], 17.03; 95% confidence interval [CI], 13.14-21.16 for RF) (OR, 119.39; 95% CI, 50.98-273.34 for death) and pneumothorax (OR, 17.15; 95% CI, 13.07-21.01 for RF) (OR, 65.49; 95% CI, 28.90-139.17 for death) were the main determinants of poor outcomes. RSV was the most frequent cause of mortality in low-income postneonatal infants. RF and death due to RSV LRTI, almost exclusively associated with prematurity and cardiopulmonary diseases in industrialized countries, primarily affect term infants in a developing world environment. Poor outcomes at hospitals are frequent and associated with the cooccurrence of bacterial sepsis and clinically significant pneumothoraxes.
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ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201603-0658OC