The Hippocampus Encodes Distances in Multidimensional Feature Space

The hippocampal formation encodes maps of the physical environment [1-5]. A key question in neuroscience is whether its spatial coding principles also provide a universal metric for the organization of non-spatial information. Initial evidence comes from studies revealing directional modulation of f...

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Vydané v:Current biology Ročník 29; číslo 7; s. 1226
Hlavní autori: Theves, Stephanie, Fernandez, Guillén, Doeller, Christian F
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England 01.04.2019
Predmet:
Adult
Female
Hippocampus - physiology
Humans
Magnetic Resonance Imaging
Male
Space Perception - physiology
Young Adult
conceptual knowledge
spatial coding
cognitive map
cognitive geometry
ISSN:1879-0445, 1879-0445
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Popis
Shrnutí:The hippocampal formation encodes maps of the physical environment [1-5]. A key question in neuroscience is whether its spatial coding principles also provide a universal metric for the organization of non-spatial information. Initial evidence comes from studies revealing directional modulation of fMRI responses in humans [6, 7] during navigation through abstract spaces and the involvement of place and grid cells in encoding of non-spatial feature dimensions [8]. However, a critical feature of a map-like representation is information about distances between locations, which has yet only been demonstrated for physical space [4, 9]. Here, we probe whether the hippocampus similarly encodes distances between points in an abstract space spanned by continuous stimulus-feature dimensions that were relevant to the acquisition of a novel concept. We find that, after learning, two-dimensional distances between individual positions in the abstract space were represented in the hippocampal multivoxel pattern as well as in the univariate hippocampal signal as indexed by fMRI adaptation. These results support the notion that the hippocampus computes domain-general, multidimensional cognitive maps along continuous dimensions.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1879-0445
1879-0445
DOI:10.1016/j.cub.2019.02.035