The endothelial barrier and cancer metastasis: Does the protective facet of platelet function matter?
[Display omitted] Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet–cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory c...
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| Veröffentlicht in: | Biochemical pharmacology Jg. 176; S. 113886 |
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| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
England
Elsevier Inc
01.06.2020
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| ISSN: | 0006-2952, 1873-2968, 1873-2968 |
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| Abstract | [Display omitted]
Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet–cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory conditions has been recently described, a phenomenon that could also operate in cancer–related inflammation. It is tempting to speculate that some antiplatelet strategies to combat cancer metastasis may impair the endogenous platelet–dependent mechanisms preserving endothelial barrier function. If the protective function of platelets is impaired, it may lead to increased endothelial permeability and more efficient cancer cell intravasation in the primary tumor and cancer cell extravasation at metastatic sites. In this commentary, we discuss current evidence that could support this hypothesis. |
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| AbstractList | [Display omitted]
Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet–cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory conditions has been recently described, a phenomenon that could also operate in cancer–related inflammation. It is tempting to speculate that some antiplatelet strategies to combat cancer metastasis may impair the endogenous platelet–dependent mechanisms preserving endothelial barrier function. If the protective function of platelets is impaired, it may lead to increased endothelial permeability and more efficient cancer cell intravasation in the primary tumor and cancer cell extravasation at metastatic sites. In this commentary, we discuss current evidence that could support this hypothesis. Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet-cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory conditions has been recently described, a phenomenon that could also operate in cancer-related inflammation. It is tempting to speculate that some antiplatelet strategies to combat cancer metastasis may impair the endogenous platelet-dependent mechanisms preserving endothelial barrier function. If the protective function of platelets is impaired, it may lead to increased endothelial permeability and more efficient cancer cell intravasation in the primary tumor and cancer cell extravasation at metastatic sites. In this commentary, we discuss current evidence that could support this hypothesis.Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet-cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory conditions has been recently described, a phenomenon that could also operate in cancer-related inflammation. It is tempting to speculate that some antiplatelet strategies to combat cancer metastasis may impair the endogenous platelet-dependent mechanisms preserving endothelial barrier function. If the protective function of platelets is impaired, it may lead to increased endothelial permeability and more efficient cancer cell intravasation in the primary tumor and cancer cell extravasation at metastatic sites. In this commentary, we discuss current evidence that could support this hypothesis. Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet-cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory conditions has been recently described, a phenomenon that could also operate in cancer-related inflammation. It is tempting to speculate that some antiplatelet strategies to combat cancer metastasis may impair the endogenous platelet-dependent mechanisms preserving endothelial barrier function. If the protective function of platelets is impaired, it may lead to increased endothelial permeability and more efficient cancer cell intravasation in the primary tumor and cancer cell extravasation at metastatic sites. In this commentary, we discuss current evidence that could support this hypothesis. |
| ArticleNumber | 113886 |
| Author | Smeda, Marta Stojak, Marta Przyborowski, Kamil Chlopicki, Stefan |
| Author_xml | – sequence: 1 givenname: Marta surname: Smeda fullname: Smeda, Marta organization: Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland – sequence: 2 givenname: Kamil surname: Przyborowski fullname: Przyborowski, Kamil organization: Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland – sequence: 3 givenname: Marta surname: Stojak fullname: Stojak, Marta organization: Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland – sequence: 4 givenname: Stefan surname: Chlopicki fullname: Chlopicki, Stefan email: stefan.chlopicki@jcet.eu organization: Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32113813$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1158/0008-5472.CAN-18-0887 10.3324/haematol.2017.182162 10.1111/j.1582-4934.2002.tb00307.x 10.1111/jth.14443 10.1182/blood-2014-12-617159 10.1182/blood-2017-06-742676 10.1186/s13045-018-0669-2 10.1016/j.blre.2014.10.003 10.1159/000431356 10.1002/ijc.28146 10.1056/NEJMoa1803955 10.1111/jcmm.14156 10.1038/s41467-017-02402-6 10.1111/j.1476-5381.1993.tb12803.x 10.1158/0008-5472.CAN-09-1370 10.1111/jth.13250 10.1126/science.1203543 10.1073/pnas.61.1.46 10.1111/j.1365-2125.2010.03879.x 10.1371/journal.pone.0073609 10.1097/MOH.0b013e3283642267 10.1016/j.thromres.2018.12.014 10.1182/blood-2007-11-123620 10.2353/ajpath.2009.090460 10.1182/blood-2002-12-3882 10.1056/NEJM194906302402601 10.1172/jci.insight.88245 10.1055/s-2007-991540 10.1186/s13045-018-0659-4 10.1242/dmm.036269 10.1038/onc.2015.452 10.1172/JCI200422123 10.1084/jem.193.4.459 10.1001/jama.294.1.47 10.1182/blood-2013-05-504449 10.1186/s13058-018-1013-z 10.3390/cancers9100142 10.1152/ajpheart.1988.254.4.H763 10.1126/scitranslmed.aau5898 10.1161/ATVBAHA.114.303411 10.1161/01.RES.0000267878.97021.ab 10.1016/j.pharmthera.2015.11.005 10.1172/JCI121985 10.1073/pnas.0406682102 10.1093/carcin/22.9.1349 10.1182/blood-2016-12-750711 10.1158/0008-5472.CAN-09-2123 10.1016/j.ccell.2018.03.002 10.1158/0008-5472.CAN-08-0718 10.1182/blood-2007-03-081901 10.1111/j.1538-7836.2009.03529.x 10.1158/0008-5472.CAN-16-0784 10.3390/cancers11010100 10.1111/j.1476-5381.1987.tb11367.x 10.1038/sj.bjc.6605599 10.3109/09537100903470298 10.1053/j.seminhematol.2004.09.006 10.1182/blood.2018877043 10.1016/S0140-6736(72)92982-0 10.1371/journal.pone.0152402 10.1016/j.tracli.2018.06.005 10.1038/s41416-018-0110-1 10.1080/19336918.2015.1122156 10.1146/annurev-physiol-020518-114700 10.3390/cancers9070094 10.1074/jbc.M602174200 10.1182/blood-2009-10-247296 10.1038/s41698-017-0011-4 10.1007/BF00121490 10.1093/carcin/bgt332 10.1158/0008-5472.CAN-19-1181 10.1038/nature12501 10.1111/j.1538-7836.2011.04317.x 10.1152/ajpheart.1998.275.3.H1054 10.1161/01.RES.76.2.199 10.1124/mol.113.084988 10.1182/blood-2017-05-743187 10.1016/j.ccr.2013.05.008 10.1080/19336918.2015.1059563 10.1073/pnas.1417273112 10.1093/glycob/cwy020 10.1080/15384047.2015.1078025 10.1111/j.1476-5381.2012.01991.x 10.1158/1078-0432.CCR-15-2664 10.1002/ijc.2910110322 10.1073/pnas.1411082111 10.1001/jama.2016.5989 10.15252/emmm.201404193 10.1159/000454696 10.1152/physrev.00016.2011 10.18632/oncotarget.24891 10.1016/S1470-2045(12)70112-2 10.1529/biophysj.107.113613 10.1007/s10555-014-9498-0 10.1084/jem.20142076 10.1158/0008-5472.CAN-16-1084 10.1038/s41598-017-04324-1 10.1016/S0140-6736(10)61543-7 10.1038/ncomms6256 10.18632/oncotarget.22339 10.1182/blood-2004-10-3985 10.1080/09537104.2018.1428739 10.1182/blood-2009-05-222273 10.1056/NEJMra0800887 10.1186/s12885-018-4445-z 10.1038/sj.bjc.6604240 10.1074/jbc.M117.791012 10.1371/journal.pone.0055740 10.1182/blood-2016-09-742999 10.1016/j.cct.2016.10.004 10.1016/j.mvr.2009.11.006 10.1182/blood-2017-02-769893 10.4161/cbt.10.10.13236 10.1002/jcp.21718 10.1016/S0140-6736(10)62110-1 10.1016/j.celrep.2018.03.092 10.1016/j.prostaglandins.2017.12.002 10.1186/s12959-016-0099-8 |
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| Keywords | Cancer metastasis Platelet inhibition Platelet-cancer cell interaction Inflammation-associated hemostasis |
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| References | Menter, Tucker, Kopetz, Sood, Crissman, Honn (b0015) 2014; 33 Bergmeier, Stefanini (b0615) 2013; 20 Versteeg, Heemskerk, Levi, Reitsma (b0420) 2013; 93 Miyata, Takemoto, Okumura, Nishio, Fujita (b0495) 2017; 7 Ahn, Lee, Choi, Choi (b0180) 2018; 134 Radziwon-Balicka, Medina, O’Driscoll, Treumann, Bazou, Inkielewicz-Stepniak, Radomski, Jow, Radomski (b0075) 2012; 167 Wu, Lee, Bogdanovic, Prodeus, Gariépy, Kerbel (b0585) 2015; 7 Kowalska, Mahmud, Lambert, Poncz, Slungaard (b0485) 2007; 110 Ho-Tin-Noé, Carbo, Demers, Cifuni, Goerge, Wagner (b0455) 2009; 175 Boucharaba, Serre, Grès, Saulnier-Blache, Bordet, Guglielmi, Clézardin, Peyruchaud (b0120) 2004; 114 Zhang, Cook, Manson, Lee, Buring (b0255) 2008; 98 Ruggeri, Mendolicchio (b0405) 2007; 100 Haemmerle, Stone, Menter, Afshar-Kharghan, Sood (b0035) 2018; 33 Golebiewska, Poole (b0335) 2015; 29 Xing, Birukova (b0575) 2010; 79 Rothwell, Fowkes, Belch, Ogawa, Warlow, Meade (b0230) 2011; 377 Jackson, Sosnoski, Ohanessian, Chandler, Mobley, Meisel, Mastro (b0270) 2017; 77 Lo, Burhop, Kaplan, Malik (b0540) 1988; 254 Plantureux, Mège, Crescence, Carminita, Robert, Cointe, Brouilly, Ezzedine, Dignat-George, Dubois, Panicot-Dubois (b0360) 2019; 80 Buczek, Denslow, Mateuszuk, Proniewski, Wojcik, Sitek, Fedorowicz, Jasztal, Kus, Chmura-Skirlinska, Gurbiel, Wietrzyk, Chlopicki (b0525) 2018; 18 Smeda, Kieronska, Proniewski, Jasztal, Selmi, Wandzel, Zakrzewska, Wojcik, Przyborowski, Derszniak, Stojak, Kaczor, Buczek, Watala, Wietrzyk, Chlopicki (b0265) 2018; 9 Ho-Tin-Noé, Goerge, Cifuni, Duerschmied, Wagner (b0450) 2008; 68 Sierko, Wojtukiewicz (b0105) 2007; 33 Gasic, Gasic, Stewart (b0145) 1968; 61 Nieswandt, Hafner, Echtenacher, Männel (b0065) 1999; 59 Radomski, Palmer, Moncada (b9000) 1987; 92 Volz, Mammadova-Bach, Gil-Pulido, Nandigama, Remer, Sorokin, Zernecke, Abrams, Ergün, Henke, Nieswandt (b0170) 2019; 133 Bae, Kim, Park, Rezaie (b0305) 2009; 219 Rayes, Jadoui, Lax, Gros, Wichaiyo, Ollivier, Denis, Ware, Nieswandt, Jandrot-Perrus, Watson, Ho-Tin-Noé (b0470) 2018; 103 Reddel, Tan, Chen (b0295) 2019; 11 Mammadova-Bach, Zigrino, Brucker, Bourdon, Freund, De Arcangelis, Abrams, Orend, Gachet, Mangin (b0085) 2016; 1 Wong (b0195) 2001; 22 Lee, Bergmeier (b0460) 2016; 14 Rayes, Lax, Wichaiyo, Watson, Di, Lombard, Grygielska, Smith, Skordilis, Watson (b0480) 2017; 8 Yu, Yan, Yang, Wu, Ling, Chen, Tang, Tan, Cao, Wu, Yan, Wang (b0090) 2014; 5 Edwards (b0020) 1949; 240 DeFeo, Hayes, Chernick, Van Ryn, Gilmour (b0215) 2010; 10 Ho-Tin-Noé, Goerge, Wagner (b0340) 2009; 69 Auvergne, Wu, Connell, Au, Cornwell, Osipovitch, Benraiss, Dangelmajer, Guerrero-Cazares, Quinones-Hinojosa, Goldman (b0205) 2016; 35 Linquette, Mesmacque, Fossati, Luez, Beghin (b0025) 1964; 92 Herzog, Fu, Wilson, Hess, Sen, McDaniel, Pan, Sheng, Yago, Silasi-Mansat, McGee, May, Nieswandt, Morris, Lupu, Coughlin, McEver, Chen, Kahn, Xia (b0445) 2013; 502 Deppermann (b0390) 2018; 29 Rothwell, Wilson, Elwin, Norrving, Algra, Warlow, Meade (b0225) 2010; 376 Gros, Syvannarath, Lamrani, Ollivier, Loyau, Goerge, Nieswandt, Jandrot-Perrus, Ho-Tin-Noé (b0440) 2015; 126 Arachiche, de la Fuente, Nieman (b0310) 2013; 8 McNeil, Nelson, Woods, Lockery, Wolfe, Reid, Kirpach, Shah, Ives, Storey, Ryan, Tonkin, Newman, Williamson, Margolis, Ernst, Abhayaratna, Stocks, Fitzgerald, Orchard, Trevaks, Beilin, Donnan, Gibbs, Johnston, Radziszewska, Grimm, Murray (b0005) 2018; 379 Honk (b0185) 1983; 1 Feistritzer, Riewald (b0300) 2005; 105 Alexander, Minton, Hayes, Goss, Van Ryn, Gilmour (b0240) 2015; 16 Franses, Drosu, Gibson, Chitalia, Edelman (b0350) 2013; 133 Kopp, Placke, Salih (b0040) 2009; 69 Cook, Lee, Gaziano, Gordon, Ridker, Manson, Hennekens, Buring (b0250) 2005; 294 Schumacher, Strilic, Sivaraj, Wettschureck, Offermanns (b0080) 2013; 24 Cho, Noh, Haemmerle, Li, Park, Hu, Hisamatsu, Mitamura, Mak, Kunapuli, Ma, Sood, Afshar-Kharghan (b0130) 2017; 130 Boulaftali, Hess, Getz, Cholka, Stolla, Mackman, Owens, Ware, Kahn, Bergmeier (b0430) 2013; 123 Elaskalani, Falasca, Moran, Berndt, Metharom (b0115) 2017; 9 Buijs, Laghmani, van den Akker, Tieken, Vletter, van der Molen, Crooijmans, Kroone, Le Dévédec, van der Pluijm, Versteeg (b0245) 2019; 17 Birukova, Meng, Tian, Meliton, Sarich, Quilliam, Birukov (b0600) 1852; 2015 Ho-Tin-Noé, Boulaftali, Camerer (b0330) 2018; 131 Herman, Fazakas, Haskó, Molnár, Mészáros, Nyúl-Tóth, Szabó, Erdélyi, Ardelean, Hermenean, Krizbai, Wilhelm (b0520) 2019; 23 Dovizio, Maier, Alberti, Di Francesco, Marcantoni, Munch, John, Suess, Sgambato, Steinhilber, Patrignani (b0125) 2013; 84 Schlesinger (b0055) 2018; 11 Mierke, Zitterbart, Kollmannsberger, Raupach, Schlötzer-Schrehardt, Goecke, Behrens, Fabry (b0345) 2008; 94 Nieswandt, Watson (b0410) 2003; 102 Philippe, Philippe, Fouqueray, Perez, Lebret, Baud (b0060) 1993; 143 Gao, Alwhaibi, Artham, Verma, Somanath (b0570) 2018; 118 Mendolicchio, Ruggeri (b0400) 2005; 42 Bambace, Levis, Holmes (b0320) 2010; 21 Best, Wesseling, Wurdinger (b0110) 2018; 78 Pachmayr, Treese, Stein (b0515) 2017; 33 Filep, Földes-Filep, Sirois (b0595) 1993; 108 Maloney, Silliman, Ambruso, Wang, Tuder, Voelkel (b0370) 1998; 275 Estevez, Shen, Du (b0605) 2015; 35 Ozaki, Tamura, Suzuki-Inoue (b0465) 2016; 14 Draijer, Atsma, Van Der Laarse, Van Hinsbergh (b0590) 1995; 76 Azevedo, Follain, Patthabhiraman, Harlepp, Goetz (b0550) 2015; 9 Bibbins-Domingo, Grossman, Curry, Davidson, Epling, García, Gillman, Harper, Kemper, Krist, Kurth, Landefeld, Mangione, Owens, Phillips, Phipps, Pignone, Siu (b0285) 2016; 315 Nachman, Rafii (b0325) 2008; 359 Gros, Ollivier, Ho-Tin-Noé (b0380) 2014; 5 Badolia, Inamdar, Manne, Dangelmaier, Eble, Kunapuli (b0510) 2017; 292 Martín-Granado, Ortiz-Rivero, Carmona, Gutiérrez-Herrero, Barrera, San-Segundo, Sequera, Perdiguero, Lozano, Martín-Herrero, Ramón González-Porras, Muñoz-Chápuli, Porras, Guerrero (b0175) 2017; 8 Nieswandt, Schulte, Bergmeier, Mokhtari-Nejad, Rackebrandt, Cazenave, Ohlmann, Gachet, Zirngibl (b0505) 2001; 193 Coyle, Cafferty, Rowley, MacKenzie, Berkman, Gupta, Pramesh, Gilbert, Kynaston, Cameron, Wilson, Ring, Langley (b0280) 2016; 51 Payne, Ponomaryov, Watson, Brill (b0490) 2017; 129 Elwood, Morgan, Pickering, Galante, Weightman, Morris, Kelson, Dolwani (b0260) 2016; 11 Molnár, Fazakas, Haskó, Sipos, Nagy, Nyúl-Tóth, Farkas, Végh, Váró, Galajda, Krizbai, Wilhelm (b0560) 2016; 10 Wood, Hilgard (b0275) 1972; 2 Nojiri, Hosoda, Tokudome, Miura, Ishikane, Otani, Kishimoto, Shintani, Inoue, Kimura, Sawabata, Minami, Nakagiri, Funaki, Takeuchi, Maeda, Kidoya, Kiyonari, Arai, Hasegawa, Takakura, Hori, Ohno, Miyazato, Mochizuki, Okumura, Kangawa, Yanagisawa (b0580) 2015; 112 Hottz, Lopes, Freitas, Valls-De-Souza, Oliveira, Bozza, Da Poian, Weyrich, Zimmerman, Bozza, Bozza (b0375) 2013; 122 Ho-Tin-Noé, Jadoui (b0395) 2018; 25 Lucotti, Cerutti, Soyer, Gil-Bernabé, Gomes, Allen, Smart, Markelc, Watson, Armstrong, Mitchell, Warner, Ridley, Muschel (b0220) 2019; 129 Ma, Perini, McKnight, Dicay, Klein, Hollenberg, Wallace (b0140) 2005; 102 Takagi, Sato, Oh-hara, Takami, Koike, Mishima, Hatake, Fujita (b0500) 2013; 8 Noble, Pasi (b0030) 2010; 102 Radziwon-Balicka, Santos-Martinez, Corbalan, O’Sullivan, Treumann, Gilmer, Radomski, Medina (b0100) 2014; 35 Teixeira, Kozlowski, Micheli, Vilela-Silva, Borsig, Pavão (b0160) 2018; 28 Labelle, Begum, Hynes (b0135) 2014; 111 Raposeiras-Roubín, Abu-Assi, Muñoz-Pousa, Cespón-Fernández, Cobas-Paz, Caneiro-Queija, López-Rodríguez, Pérez-Casares, Jamhour-Chelh, Castiñeira-Busto, Barreiro-Pardal, Calvo-Iglesias, Íñiguez-Romo (b0290) 2019; 174 Goerge, Ho-Tin-Noe, Carbo, Benarafa, Remold-O’Donnell, Zhao, Cifuni, Wagner (b0425) 2008; 111 Chaffer, Weinberg (b0545) 2011; 331 Erpenbeck, Schön (b0155) 2010; 115 Papa, Jiang, Korin, Chen, Langan, Waterhouse, Nash, Caroff, Graveline, Vernet, Mammoto, Mammoto, Jain, Kamm, Gounis, Ingber (b0210) 2019; 11 Lawler (b0365) 2002; 6 Deppermann, Kraft, Volz, Schuhmann, Beck, Wolf, Stegner, Stoll, Nieswandt (b0435) 2017; 129 Li, Lee, Liu, Wang, Song, Han, Yao, Xie, Zhu, Grossmann, Cleary, Chen, Bode, Dong (b0190) 2017; 1 Tesfamariam (b0050) 2016; 157 Algra, Rothwell (b0235) 2012; 13 Ho-Tin-Noé, Demers, Wagner (b0535) 2011; 9 Häuselmann, Roblek, Protsyuk, Huck, Knopfova, Grässle, Bauer, Schneider, Borsig (b0475) 2016; 76 Elaskalani, Berndt, Falasca, Metharom (b0070) 2017; 9 Niers, Brüggemann, van Sluis, Liu, Versteeg, Büller, van Noorden, Reitsma, Spek, Richel (b0200) 2009; 7 Martin, Seano, Jain (b0355) 2019; 81 Hillgruber, Pöppelmann, Weishaupt, athri, Steingräber, Wessel, Berdel, Gessner, Ho-Tin-Noé, Vestweber (b0385) 2015; 212 Schneider (b0415) 2011; 72 Xu, Yousef, Ni (b0045) 2018; 131 May, Hagedorn, Pleines, Bender, Vögtle, Eble, Elvers, Nieswandt (b0610) 2009; 114 Smeda, Kieronska, Adamski, Proniewski, Sternak, Mohaissen, Przyborowski, Derszniak, Kaczor, Stojak, Buczek, Jasztal, Wietrzyk, Chlopicki (b0530) 2018; 20 Ward, Lake, Faraji, Sperger, Martin, Gilliard, Ku, Rodems, Niles, Tillman, Yin, Hunter, Sowalsky, Lang, Kelly (b0095) 2018; 23 Qi, Chen, Liang, Xu, Gu, Wu, Fan, Ren, Liu, Zhang, Li, Liu, Liang (b0165) 2018; 11 Suraj, Kurpińska, Zakrzewska, Sternak, Stojak, Jasztal, Walczak, Chlopicki (b0555) 2019; 12 Serebruany, Cherepanov, Golukhova, Kim (b0010) 2015; 132 Holinstat, Voss, Bilodeau, McLaughlin, Cleator, Hamm (b0315) 2006; 281 Cask, Gasic, Galanti, Johnson, Murphy (b0150) 1973; 11 Bartolini, Cardaci, Lamba, Oddo, Marchiò, Cassoni, Amoreo, Corti, Testori, Bussolino, Pasqualini, Arap, Corà, Di Nicolantonio, Marchiò (b0565) 2016; 22 Best (10.1016/j.bcp.2020.113886_b0110) 2018; 78 Bibbins-Domingo (10.1016/j.bcp.2020.113886_b0285) 2016; 315 Feistritzer (10.1016/j.bcp.2020.113886_b0300) 2005; 105 Arachiche (10.1016/j.bcp.2020.113886_b0310) 2013; 8 Algra (10.1016/j.bcp.2020.113886_b0235) 2012; 13 Radziwon-Balicka (10.1016/j.bcp.2020.113886_b0100) 2014; 35 Radziwon-Balicka (10.1016/j.bcp.2020.113886_b0075) 2012; 167 May (10.1016/j.bcp.2020.113886_b0610) 2009; 114 Tesfamariam (10.1016/j.bcp.2020.113886_b0050) 2016; 157 Filep (10.1016/j.bcp.2020.113886_b0595) 1993; 108 Nojiri (10.1016/j.bcp.2020.113886_b0580) 2015; 112 Boucharaba (10.1016/j.bcp.2020.113886_b0120) 2004; 114 Auvergne (10.1016/j.bcp.2020.113886_b0205) 2016; 35 Wu (10.1016/j.bcp.2020.113886_b0585) 2015; 7 Niers (10.1016/j.bcp.2020.113886_b0200) 2009; 7 Bergmeier (10.1016/j.bcp.2020.113886_b0615) 2013; 20 Erpenbeck (10.1016/j.bcp.2020.113886_b0155) 2010; 115 Ho-Tin-Noé (10.1016/j.bcp.2020.113886_b0395) 2018; 25 Versteeg (10.1016/j.bcp.2020.113886_b0420) 2013; 93 Raposeiras-Roubín (10.1016/j.bcp.2020.113886_b0290) 2019; 174 Kowalska (10.1016/j.bcp.2020.113886_b0485) 2007; 110 Molnár (10.1016/j.bcp.2020.113886_b0560) 2016; 10 Buijs (10.1016/j.bcp.2020.113886_b0245) 2019; 17 Holinstat (10.1016/j.bcp.2020.113886_b0315) 2006; 281 Herzog (10.1016/j.bcp.2020.113886_b0445) 2013; 502 Herman (10.1016/j.bcp.2020.113886_b0520) 2019; 23 Birukova (10.1016/j.bcp.2020.113886_b0600) 1852; 2015 Mendolicchio (10.1016/j.bcp.2020.113886_b0400) 2005; 42 Nieswandt (10.1016/j.bcp.2020.113886_b0410) 2003; 102 Elaskalani (10.1016/j.bcp.2020.113886_b0115) 2017; 9 Xing (10.1016/j.bcp.2020.113886_b0575) 2010; 79 Lucotti (10.1016/j.bcp.2020.113886_b0220) 2019; 129 Teixeira (10.1016/j.bcp.2020.113886_b0160) 2018; 28 Takagi (10.1016/j.bcp.2020.113886_b0500) 2013; 8 Rothwell (10.1016/j.bcp.2020.113886_b0230) 2011; 377 Martin (10.1016/j.bcp.2020.113886_b0355) 2019; 81 Ruggeri (10.1016/j.bcp.2020.113886_b0405) 2007; 100 Rayes (10.1016/j.bcp.2020.113886_b0480) 2017; 8 Nieswandt (10.1016/j.bcp.2020.113886_b0505) 2001; 193 Suraj (10.1016/j.bcp.2020.113886_b0555) 2019; 12 Mammadova-Bach (10.1016/j.bcp.2020.113886_b0085) 2016; 1 Rothwell (10.1016/j.bcp.2020.113886_b0225) 2010; 376 Yu (10.1016/j.bcp.2020.113886_b0090) 2014; 5 Ward (10.1016/j.bcp.2020.113886_b0095) 2018; 23 Schumacher (10.1016/j.bcp.2020.113886_b0080) 2013; 24 Sierko (10.1016/j.bcp.2020.113886_b0105) 2007; 33 McNeil (10.1016/j.bcp.2020.113886_b0005) 2018; 379 Goerge (10.1016/j.bcp.2020.113886_b0425) 2008; 111 Azevedo (10.1016/j.bcp.2020.113886_b0550) 2015; 9 Reddel (10.1016/j.bcp.2020.113886_b0295) 2019; 11 Gao (10.1016/j.bcp.2020.113886_b0570) 2018; 118 Ho-Tin-Noé (10.1016/j.bcp.2020.113886_b0330) 2018; 131 Lo (10.1016/j.bcp.2020.113886_b0540) 1988; 254 Radomski (10.1016/j.bcp.2020.113886_b9000) 1987; 92 Noble (10.1016/j.bcp.2020.113886_b0030) 2010; 102 Honk (10.1016/j.bcp.2020.113886_b0185) 1983; 1 Smeda (10.1016/j.bcp.2020.113886_b0530) 2018; 20 Deppermann (10.1016/j.bcp.2020.113886_b0435) 2017; 129 Wood (10.1016/j.bcp.2020.113886_b0275) 1972; 2 Ozaki (10.1016/j.bcp.2020.113886_b0465) 2016; 14 Buczek (10.1016/j.bcp.2020.113886_b0525) 2018; 18 Schlesinger (10.1016/j.bcp.2020.113886_b0055) 2018; 11 Gros (10.1016/j.bcp.2020.113886_b0440) 2015; 126 Schneider (10.1016/j.bcp.2020.113886_b0415) 2011; 72 Gasic (10.1016/j.bcp.2020.113886_b0145) 1968; 61 Gros (10.1016/j.bcp.2020.113886_b0380) 2014; 5 Estevez (10.1016/j.bcp.2020.113886_b0605) 2015; 35 Volz (10.1016/j.bcp.2020.113886_b0170) 2019; 133 Hottz (10.1016/j.bcp.2020.113886_b0375) 2013; 122 Draijer (10.1016/j.bcp.2020.113886_b0590) 1995; 76 Cho (10.1016/j.bcp.2020.113886_b0130) 2017; 130 Elwood (10.1016/j.bcp.2020.113886_b0260) 2016; 11 Cask (10.1016/j.bcp.2020.113886_b0150) 1973; 11 Badolia (10.1016/j.bcp.2020.113886_b0510) 2017; 292 Ho-Tin-Noé (10.1016/j.bcp.2020.113886_b0450) 2008; 68 Martín-Granado (10.1016/j.bcp.2020.113886_b0175) 2017; 8 Boulaftali (10.1016/j.bcp.2020.113886_b0430) 2013; 123 Alexander (10.1016/j.bcp.2020.113886_b0240) 2015; 16 Häuselmann (10.1016/j.bcp.2020.113886_b0475) 2016; 76 Ho-Tin-Noé (10.1016/j.bcp.2020.113886_b0535) 2011; 9 Kopp (10.1016/j.bcp.2020.113886_b0040) 2009; 69 Ma (10.1016/j.bcp.2020.113886_b0140) 2005; 102 Haemmerle (10.1016/j.bcp.2020.113886_b0035) 2018; 33 Xu (10.1016/j.bcp.2020.113886_b0045) 2018; 131 Franses (10.1016/j.bcp.2020.113886_b0350) 2013; 133 Menter (10.1016/j.bcp.2020.113886_b0015) 2014; 33 DeFeo (10.1016/j.bcp.2020.113886_b0215) 2010; 10 Chaffer (10.1016/j.bcp.2020.113886_b0545) 2011; 331 Golebiewska (10.1016/j.bcp.2020.113886_b0335) 2015; 29 Edwards (10.1016/j.bcp.2020.113886_b0020) 1949; 240 Wong (10.1016/j.bcp.2020.113886_b0195) 2001; 22 Labelle (10.1016/j.bcp.2020.113886_b0135) 2014; 111 Bae (10.1016/j.bcp.2020.113886_b0305) 2009; 219 Linquette (10.1016/j.bcp.2020.113886_b0025) 1964; 92 Pachmayr (10.1016/j.bcp.2020.113886_b0515) 2017; 33 Deppermann (10.1016/j.bcp.2020.113886_b0390) 2018; 29 Nachman (10.1016/j.bcp.2020.113886_b0325) 2008; 359 Li (10.1016/j.bcp.2020.113886_b0190) 2017; 1 Papa (10.1016/j.bcp.2020.113886_b0210) 2019; 11 Philippe (10.1016/j.bcp.2020.113886_b0060) 1993; 143 Hillgruber (10.1016/j.bcp.2020.113886_b0385) 2015; 212 Nieswandt (10.1016/j.bcp.2020.113886_b0065) 1999; 59 Maloney (10.1016/j.bcp.2020.113886_b0370) 1998; 275 Plantureux (10.1016/j.bcp.2020.113886_b0360) 2019; 80 Payne (10.1016/j.bcp.2020.113886_b0490) 2017; 129 Dovizio (10.1016/j.bcp.2020.113886_b0125) 2013; 84 Lawler (10.1016/j.bcp.2020.113886_b0365) 2002; 6 Serebruany (10.1016/j.bcp.2020.113886_b0010) 2015; 132 Zhang (10.1016/j.bcp.2020.113886_b0255) 2008; 98 Ho-Tin-Noé (10.1016/j.bcp.2020.113886_b0340) 2009; 69 Miyata (10.1016/j.bcp.2020.113886_b0495) 2017; 7 Lee (10.1016/j.bcp.2020.113886_b0460) 2016; 14 Ahn (10.1016/j.bcp.2020.113886_b0180) 2018; 134 Bambace (10.1016/j.bcp.2020.113886_b0320) 2010; 21 Qi (10.1016/j.bcp.2020.113886_b0165) 2018; 11 Coyle (10.1016/j.bcp.2020.113886_b0280) 2016; 51 Rayes (10.1016/j.bcp.2020.113886_b0470) 2018; 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| References_xml | – volume: 24 start-page: 130 year: 2013 end-page: 137 ident: b0080 article-title: Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor publication-title: Cancer Cell. – volume: 84 start-page: 25 year: 2013 end-page: 40 ident: b0125 article-title: Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cellss publication-title: Mol. Pharmacol. – volume: 8 start-page: 110994 year: 2017 end-page: 111011 ident: b0175 article-title: C3G promotes a selective release of angiogenic factors from activated mouse platelets to regulate angiogenesis and tumor metastasis publication-title: Oncotarget – volume: 22 start-page: 1349 year: 2001 end-page: 1354 ident: b0195 article-title: 12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells publication-title: Carcinogenesis – volume: 93 start-page: 327 year: 2013 end-page: 358 ident: b0420 article-title: New fundamentals in hemostasis publication-title: Physiol. Rev. – volume: 129 start-page: 1702 year: 2017 end-page: 1706 ident: b0435 article-title: Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice publication-title: Blood – volume: 77 start-page: 1942 year: 2017 end-page: 1954 ident: b0270 article-title: Role of megakaryocytes in breast cancer metastasis to bone publication-title: Cancer Res. – volume: 9 start-page: 345 year: 2015 end-page: 356 ident: b0550 article-title: Metastasis of circulating tumor cells: Favorable soil or suitable biomechanics, or both? publication-title: Cell Adhes. Migr. – volume: 294 start-page: 47 year: 2005 end-page: 55 ident: b0250 article-title: Low-dose aspirin in the primary prevention of cancer. The women’s health study: a randomized controlled trial publication-title: J. Am. Med. Assoc. – volume: 157 start-page: 112 year: 2016 end-page: 119 ident: b0050 article-title: Involvement of platelets in tumor cell metastasis publication-title: Pharmacol. Ther. – volume: 29 start-page: 549 year: 2018 end-page: 555 ident: b0390 article-title: Platelets and vascular integrity publication-title: Platelets – volume: 111 start-page: E3053 year: 2014 end-page: E3061 ident: b0135 article-title: Platelets guide the formation of early metastatic niches publication-title: Proc. Natl. Acad. Sci. USA – volume: 59 start-page: 1295 year: 1999 end-page: 1300 ident: b0065 article-title: Lysis of tumor cells by natural killer cells in mice is impeded by platelets publication-title: Cancer Res. – volume: 23 start-page: 2619 year: 2019 end-page: 2631 ident: b0520 article-title: Paracellular and transcellular migration of metastatic cells through the cerebral endothelium publication-title: J. Cell. Mol. Med. – volume: 379 start-page: 1519 year: 2018 end-page: 1528 ident: b0005 article-title: Effect of aspirin on all-cause mortality in the healthy elderly publication-title: N. Engl. J. Med. – volume: 80 start-page: 291 year: 2019 end-page: 303 ident: b0360 article-title: The interaction of platelets with colorectal cancer cells inhibits tumor growth but promotes metastasis publication-title: Cancer Res. – volume: 69 start-page: 5623 year: 2009 end-page: 5626 ident: b0340 article-title: Platelets: guardians of tumor vasculature publication-title: Cancer Res. – volume: 1 year: 2016 ident: b0085 article-title: Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell-derived ADAM9 publication-title: JCI Insight. – volume: 8 start-page: e73609 year: 2013 ident: b0500 article-title: Platelets promote tumor growth and metastasis via direct interaction between aggrus/podoplanin and CLEC-2 publication-title: PLoS One – volume: 33 start-page: 11 year: 2017 end-page: 20 ident: b0515 article-title: Underlying mechanisms for distant metastasis - molecular biology publication-title: Visc. Med. – volume: 122 start-page: 3405 year: 2013 end-page: 3414 ident: b0375 article-title: Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation publication-title: Blood – volume: 129 start-page: 2013 year: 2017 end-page: 2020 ident: b0490 article-title: Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis publication-title: Blood – volume: 132 start-page: 74 year: 2015 end-page: 80 ident: b0010 article-title: The dual antiplatelet therapy trial after the FDA update: noncardiovascular deaths, cancer and optimal treatment duration publication-title: Cardiology – volume: 11 start-page: 704 year: 1973 end-page: 718 ident: b0150 article-title: Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease publication-title: Int. J. Cancer – volume: 25 start-page: 210 year: 2018 end-page: 216 ident: b0395 article-title: Spontaneous bleeding in thrombocytopenia: is it really spontaneous? publication-title: Transfus. Clin. Biol. – volume: 11 start-page: 125 year: 2018 ident: b0055 article-title: Role of platelets and platelet receptors in cancer metastasis publication-title: J. Hematol. Oncol. – volume: 315 start-page: 2564 year: 2016 end-page: 2575 ident: b0285 article-title: Screening for colorectal cancer: US preventive services task force recommendation statement publication-title: JAMA - J. Am. Med. Assoc. – volume: 102 start-page: 216 year: 2005 end-page: 220 ident: b0140 article-title: Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets publication-title: Proc. Natl. Acad. Sci. USA – volume: 13 start-page: 518 year: 2012 end-page: 527 ident: b0235 article-title: Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials publication-title: Lancet. Oncol. – volume: 22 start-page: 4923 year: 2016 end-page: 4933 ident: b0565 article-title: BCAM and LAMA5 mediate the recognition between tumor cells and the endothelium in the metastatic spreading of KRAS-mutant colorectal cancer publication-title: Clin. Cancer Res. – volume: 11 start-page: 117 year: 2018 ident: b0165 article-title: Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction publication-title: J. Hematol. Oncol. – volume: 42 start-page: 5 year: 2005 end-page: 14 ident: b0400 article-title: New perspectives on von Willebrand factor functions in hemostasis and thrombosis publication-title: Semin. Hematol. – volume: 126 start-page: 1017 year: 2015 end-page: 1026 ident: b0440 article-title: Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice publication-title: Blood – volume: 72 start-page: 672 year: 2011 end-page: 682 ident: b0415 article-title: Anti-platelet therapy: glycoprotein IIb-IIIa antagonists publication-title: British J. Clin. Pharmacol. – volume: 35 start-page: 24 year: 2015 end-page: 29 ident: b0605 article-title: Targeting integrin and integrin signaling in treating thrombosis publication-title: Arterioscler. Thromb. Vasc. Biol. – volume: 33 start-page: 712 year: 2007 end-page: 721 ident: b0105 article-title: Inhibition of platelet function: does it offer a chance of better cancer progression control? publication-title: Semin. Thromb. Hemost. – volume: 29 start-page: 153 year: 2015 end-page: 162 ident: b0335 article-title: Platelet secretion: from haemostasis to wound healing and beyond publication-title: Blood Rev. – volume: 331 start-page: 1559 year: 2011 end-page: 1564 ident: b0545 article-title: A perspective on cancer cell metastasis publication-title: Science – volume: 114 start-page: 3464 year: 2009 end-page: 3472 ident: b0610 article-title: CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis publication-title: Blood – volume: 35 start-page: 324 year: 2014 end-page: 332 ident: b0100 article-title: Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway publication-title: Carcinogenesis – volume: 94 start-page: 2832 year: 2008 end-page: 2846 ident: b0345 article-title: Breakdown of the endothelial barrier function in tumor cell transmigration publication-title: Biophys. J. – volume: 78 start-page: 3407 year: 2018 end-page: 3412 ident: b0110 article-title: Tumor-educated platelets as a noninvasive biomarker source for cancer detection and progression monitoring publication-title: Cancer Res. – volume: 20 start-page: 445 year: 2013 end-page: 450 ident: b0615 article-title: Platelet ITAM signaling publication-title: Curr. Opin. Hematol. – volume: 7 start-page: 1595 year: 2009 end-page: 1597 ident: b0200 article-title: Long-term thrombin inhibition promotes cancer cell extravasation in a mouse model of experimental metastasis publication-title: J. Thromb. Haemost. – volume: 112 start-page: 4086 year: 2015 end-page: 4089 ident: b0580 article-title: Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells publication-title: Proc. Natl. Acad. Sci. USA – volume: 175 start-page: 1699 year: 2009 end-page: 1708 ident: b0455 article-title: Innate immune cells induce hemorrhage in tumors during thrombocytopenia publication-title: Am. J. Pathol. – volume: 79 start-page: 56 year: 2010 end-page: 62 ident: b0575 article-title: ANP attenuates inflammatory signaling and Rho pathway of lung endothelial permeability induced by LPS and TNFalpha publication-title: Microvasc. Res. – volume: 11 start-page: e0152402 year: 2016 ident: b0260 article-title: Aspirin in the treatment of cancer: reductions in metastatic spread and in mortality: a systematic review and meta-analyses of published studies publication-title: PLoS One – volume: 2 start-page: 1416 year: 1972 end-page: 1417 ident: b0275 article-title: Aspirin and tumour metastasis publication-title: Lancet (London, England) – volume: 108 start-page: 323 year: 1993 end-page: 326 ident: b0595 article-title: Nitric oxide modulates vascular permeability in the rat coronary circulation publication-title: Br. J. Pharmacol. – volume: 143 start-page: 1713 year: 1993 end-page: 1723 ident: b0060 article-title: Protection from tumor necrosis factor-mediated cytolysis by platelets publication-title: Am J Pathol. – volume: 118 start-page: 1464 year: 2018 end-page: 1475 ident: b0570 article-title: Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover publication-title: Br. J. Cancer. – volume: 134 start-page: 47 year: 2018 end-page: 56 ident: b0180 article-title: Iloprost, a prostacyclin analog, inhibits the invasion of ovarian cancer cells by downregulating matrix metallopeptidase-2 (MMP-2) through the IP-dependent pathway publication-title: Prostaglandins Other Lipid Mediat. – volume: 133 start-page: 1334 year: 2013 end-page: 1344 ident: b0350 article-title: Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis publication-title: Int. J. Cancer. – volume: 61 start-page: 46 year: 1968 end-page: 52 ident: b0145 article-title: Antimetastatic effects associated with platelet reduction publication-title: Proc. Natl. Acad. Sci. USA – volume: 6 start-page: 1 year: 2002 end-page: 12 ident: b0365 article-title: Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth publication-title: J. Cell. Mol. Med. – volume: 76 start-page: 5302 year: 2016 end-page: 5312 ident: b0475 article-title: Monocyte induction of E-selectin-mediated endothelial activation releases VE-cadherin junctions to promote tumor cell extravasation in the metastasis cascade publication-title: Cancer Res. – volume: 174 start-page: 51 year: 2019 end-page: 58 ident: b0290 article-title: Risk of cancer after an acute coronary syndrome according to the type of P2Y12 inhibitor publication-title: Thromb. Res. – volume: 33 start-page: 231 year: 2014 end-page: 269 ident: b0015 article-title: Platelets and cancer: a casual or causal relationship: revisited publication-title: Cancer Metastasis Rev. – volume: 167 start-page: 787 year: 2012 end-page: 804 ident: b0075 article-title: Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance publication-title: Br. J. Pharmacol. – volume: 21 start-page: 85 year: 2010 end-page: 93 ident: b0320 article-title: The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets publication-title: Platelets – volume: 68 start-page: 6851 year: 2008 end-page: 6858 ident: b0450 article-title: Platelet granule secretion continuously prevents intratumor hemorrhage publication-title: Cancer Res. – volume: 11 start-page: E100 year: 2019 ident: b0295 article-title: Thrombin generation and cancer: contributors and consequences publication-title: Cancers (Basel). – volume: 35 start-page: 3817 year: 2016 end-page: 3828 ident: b0205 article-title: PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo publication-title: Oncogene – volume: 377 start-page: 31 year: 2011 end-page: 41 ident: b0230 article-title: Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials publication-title: Lancet – volume: 502 start-page: 105 year: 2013 end-page: 109 ident: b0445 article-title: Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2 publication-title: Nature – volume: 98 start-page: 989 year: 2008 end-page: 991 ident: b0255 article-title: Low-dose aspirin and breast cancer risk: results by tumour characteristics from a randomised trial publication-title: Br. J. Cancer. – volume: 5 start-page: 5256 year: 2014 ident: b0090 article-title: Platelets promote tumour metastasis via interaction between TLR4 and tumour cell-released high-mobility group box1 protein publication-title: Nat. Commun. – volume: 115 start-page: 3427 year: 2010 end-page: 3436 ident: b0155 article-title: Deadly allies: the fatal interplay between platelets and metastasizing cancer cells publication-title: Blood – volume: 9 start-page: E94 year: 2017 ident: b0070 article-title: Targeting platelets for the treatment of cancer publication-title: Cancers (Basel) – volume: 18 start-page: 582 year: 2018 ident: b0525 article-title: Alterations in NO- and PGI2- dependent function in aorta in the orthotopic murine model of metastatic 4T1 breast cancer: relationship with pulmonary endothelial dysfunction and systemic inflammation publication-title: BMC Cancer – volume: 212 start-page: 1255 year: 2015 end-page: 1266 ident: b0385 article-title: Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia publication-title: J. Exp. Med. – volume: 92 start-page: 689 year: 1964 end-page: 698 ident: b0025 article-title: Recurrent and migratory venous thromboses publication-title: Prog. Med. (Paris) – volume: 14 start-page: 27 year: 2016 ident: b0465 article-title: New horizon in platelet function: with special reference to a recently-found molecule, CLEC-2 publication-title: Thromb. J. – volume: 20 start-page: 86 year: 2018 ident: b0530 article-title: Nitric oxide deficiency and endothelial-mesenchymal transition of pulmonary endothelium in the progression of 4T1 metastatic breast cancer in mice publication-title: Breast Cancer Res. – volume: 110 start-page: 1903 year: 2007 end-page: 1905 ident: b0485 article-title: Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge publication-title: Blood – volume: 9 start-page: 17810 year: 2018 end-page: 17824 ident: b0265 article-title: Dual antiplatelet therapy with clopidogrel and aspirin increases mortality in 4T1 metastatic breast cancer-bearing mice by inducing vascular mimicry in primary tumour publication-title: Oncotarget – volume: 114 start-page: 1714 year: 2004 end-page: 1725 ident: b0120 article-title: Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer publication-title: J. Clin. Invest. – volume: 275 start-page: H1054 year: 1998 end-page: H1061 ident: b0370 article-title: In vitro release of vascular endothelial growth factor during platelet aggregation publication-title: Am. J. Physiol. - Hear. Circ. Physiol. – volume: 292 start-page: 14516 year: 2017 end-page: 14531 ident: b0510 article-title: Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets publication-title: J. Biol. Chem. – volume: 130 start-page: 1235 year: 2017 end-page: 1242 ident: b0130 article-title: Role of ADP receptors on platelets in the growth of ovarian cancer publication-title: Blood – volume: 51 start-page: 56 year: 2016 end-page: 64 ident: b0280 article-title: Add-Aspirin investigators, ADD-ASPIRIN: a phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours publication-title: Contemp. Clin. Trials – volume: 5 start-page: 678 year: 2014 ident: b0380 article-title: Platelets in inflammation: regulation of leukocyte activities and vascular repair publication-title: Front. Immunol. – volume: 23 start-page: 808 year: 2018 end-page: 822 ident: b0095 article-title: Platelets promote metastasis via binding tumor CD97 leading to bidirectional signaling that coordinates transendothelial migration publication-title: Cell Rep. – volume: 28 start-page: 427 year: 2018 end-page: 434 ident: b0160 article-title: Sulfated fucans and a sulfated galactan from sea urchins as potent inhibitors of selectin-dependent hematogenous metastasis publication-title: Glycobiology – volume: 133 start-page: 2696 year: 2019 end-page: 2706 ident: b0170 article-title: Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice publication-title: Blood – volume: 240 start-page: 1031 year: 1949 end-page: 1035 ident: b0020 article-title: Migrating thrombophlebitis associated with carcinoma publication-title: N. Engl. J. Med. – volume: 1 start-page: 8 year: 2017 ident: b0190 article-title: Inhibiting breast cancer by targeting the thromboxane A2 pathway publication-title: Npj Precis. Oncol. – volume: 81 start-page: 505 year: 2019 end-page: 534 ident: b0355 article-title: Normalizing function of tumor vessels: progress, opportunities, and challenges publication-title: Annu. Rev. Physiol. – volume: 105 start-page: 3178 year: 2005 end-page: 3184 ident: b0300 article-title: Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation publication-title: Blood – volume: 10 start-page: 1001 year: 2010 end-page: 1008 ident: b0215 article-title: Use of dabigatran etexilate to reduce breast cancer progression publication-title: Cancer Biol. Ther. – volume: 9 start-page: 56 year: 2011 end-page: 65 ident: b0535 article-title: How platelets safeguard vascular integrity publication-title: J. Thromb. Haemost. – volume: 92 start-page: 639 year: 1987 end-page: 646 ident: b9000 article-title: The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide publication-title: Br. J. Pharmacol. – volume: 12 start-page: dmm036269 year: 2019 ident: b0555 article-title: Early and late endothelial response in breast cancer metastasis in mice: simultaneous quantification of endothelial biomarkers using a mass spectrometry-based method publication-title: Dis. Model. Mech. – volume: 14 start-page: 645 year: 2016 end-page: 654 ident: b0460 article-title: Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development publication-title: J. Thromb. Haemost. – volume: 33 start-page: 965 year: 2018 end-page: 983 ident: b0035 article-title: The platelet lifeline to cancer: challenges and opportunities publication-title: Cancer Cell. – volume: 281 start-page: 26665 year: 2006 end-page: 26674 ident: b0315 article-title: PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation publication-title: J. Biol. Chem. – volume: 17 start-page: 951 year: 2019 end-page: 963 ident: b0245 article-title: The direct oral anticoagulants rivaroxaban and dabigatran do not inhibit orthotopic growth and metastasis of human breast cancer in mice publication-title: J. Thromb. Haemost. – volume: 219 start-page: 744 year: 2009 end-page: 751 ident: b0305 article-title: Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 kinase publication-title: J. Cell. Physiol. – volume: 111 start-page: 4958 year: 2008 end-page: 4964 ident: b0425 article-title: Inflammation induces hemorrhage in thrombocytopenia publication-title: Blood – volume: 69 start-page: 7775 year: 2009 end-page: 7783 ident: b0040 article-title: Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity publication-title: Cancer Res. – volume: 103 start-page: e256 year: 2018 end-page: e258 ident: b0470 article-title: The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent publication-title: Haematologica – volume: 100 start-page: 1673 year: 2007 end-page: 1685 ident: b0405 article-title: Adhesion mechanisms in platelet function publication-title: Circ. Res. – volume: 9 year: 2017 ident: b0115 article-title: The role of platelet-derived ADP and ATP in promoting pancreatic cancer cell survival and gemcitabine resistance publication-title: Cancers (Basel) – volume: 11 year: 2019 ident: b0210 article-title: Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models publication-title: Sci. Transl. Med. – volume: 376 start-page: 1741 year: 2010 end-page: 1750 ident: b0225 article-title: Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials publication-title: Lancet – volume: 102 start-page: S2 year: 2010 end-page: S9 ident: b0030 article-title: Epidemiology and pathophysiology of cancer-associated thrombosis publication-title: Br. J. Cancer. – volume: 7 start-page: 770 year: 2015 end-page: 787 ident: b0585 article-title: Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2 publication-title: EMBO Mol. Med. – volume: 7 start-page: 4059 year: 2017 ident: b0495 article-title: Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation publication-title: Sci. Rep. – volume: 123 start-page: 908 year: 2013 end-page: 916 ident: b0430 article-title: Platelet ITAM signaling is critical for vascular integrity in infammation publication-title: J. Clin. Invest. – volume: 254 start-page: H763 year: 1988 end-page: H771 ident: b0540 article-title: Role of platelets in maintenance of pulmonary vascular permeability to protein publication-title: Am. J. Physiol. - Hear. Circ. Physiol. – volume: 102 start-page: 449 year: 2003 end-page: 461 ident: b0410 article-title: Platelet-collagen interaction: Is GPVI the central receptor? publication-title: Blood – volume: 8 start-page: e55740 year: 2013 ident: b0310 article-title: Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets publication-title: PLoS One. – volume: 131 start-page: 1777 year: 2018 end-page: 1789 ident: b0045 article-title: Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents publication-title: Blood – volume: 1 start-page: 103 year: 1983 end-page: 114 ident: b0185 article-title: Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin/thromboxane A2 system publication-title: Clin. Exp. Metastasis – volume: 16 start-page: 1802 year: 2015 end-page: 1811 ident: b0240 article-title: Thrombin inhibition and cyclophosphamide synergistically block tumor progression and metastasis publication-title: Cancer Biol. Ther. – volume: 8 start-page: 2239 year: 2017 ident: b0480 article-title: The podoplanin-CLEC-2 axis inhibits inflammation in sepsis publication-title: Nat Commun. – volume: 2015 start-page: 778 year: 1852 end-page: 791 ident: b0600 article-title: Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1 publication-title: Biochim. Biophys. Acta – volume: 10 start-page: 269 year: 2016 end-page: 281 ident: b0560 article-title: Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: role of Rac and PI3K publication-title: Cell Adh. Migr. – volume: 131 start-page: 277 year: 2018 end-page: 288 ident: b0330 article-title: Platelets and vascular integrity: How platelets prevent bleeding in inflammation publication-title: Blood – volume: 76 start-page: 199 year: 1995 end-page: 208 ident: b0590 article-title: cGMP and nitric oxide modulate thrombin-induced endothelial permeability: regulation via different pathways in human aortic and umbilical vein endothelial cells publication-title: Circ. Res. – volume: 359 start-page: 1261 year: 2008 end-page: 1270 ident: b0325 article-title: Platelets, petechiae, and preservation of the vascular wall publication-title: N. Engl. J. Med. – volume: 129 start-page: 1845 year: 2019 end-page: 1862 ident: b0220 article-title: Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2 publication-title: J. Clin. Invest. – volume: 193 start-page: 459 year: 2001 end-page: 469 ident: b0505 article-title: Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice publication-title: J. Exp. Med. – volume: 78 start-page: 3407 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0110 article-title: Tumor-educated platelets as a noninvasive biomarker source for cancer detection and progression monitoring publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-18-0887 – volume: 103 start-page: e256 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0470 article-title: The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent publication-title: Haematologica doi: 10.3324/haematol.2017.182162 – volume: 6 start-page: 1 year: 2002 ident: 10.1016/j.bcp.2020.113886_b0365 article-title: Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth publication-title: J. Cell. Mol. Med. doi: 10.1111/j.1582-4934.2002.tb00307.x – volume: 17 start-page: 951 year: 2019 ident: 10.1016/j.bcp.2020.113886_b0245 article-title: The direct oral anticoagulants rivaroxaban and dabigatran do not inhibit orthotopic growth and metastasis of human breast cancer in mice publication-title: J. Thromb. Haemost. doi: 10.1111/jth.14443 – volume: 126 start-page: 1017 year: 2015 ident: 10.1016/j.bcp.2020.113886_b0440 article-title: Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice publication-title: Blood doi: 10.1182/blood-2014-12-617159 – volume: 131 start-page: 277 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0330 article-title: Platelets and vascular integrity: How platelets prevent bleeding in inflammation publication-title: Blood doi: 10.1182/blood-2017-06-742676 – volume: 11 start-page: 125 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0055 article-title: Role of platelets and platelet receptors in cancer metastasis publication-title: J. Hematol. Oncol. doi: 10.1186/s13045-018-0669-2 – volume: 29 start-page: 153 year: 2015 ident: 10.1016/j.bcp.2020.113886_b0335 article-title: Platelet secretion: from haemostasis to wound healing and beyond publication-title: Blood Rev. doi: 10.1016/j.blre.2014.10.003 – volume: 5 start-page: 678 year: 2014 ident: 10.1016/j.bcp.2020.113886_b0380 article-title: Platelets in inflammation: regulation of leukocyte activities and vascular repair publication-title: Front. Immunol. – volume: 132 start-page: 74 year: 2015 ident: 10.1016/j.bcp.2020.113886_b0010 article-title: The dual antiplatelet therapy trial after the FDA update: noncardiovascular deaths, cancer and optimal treatment duration publication-title: Cardiology doi: 10.1159/000431356 – volume: 133 start-page: 1334 year: 2013 ident: 10.1016/j.bcp.2020.113886_b0350 article-title: Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis publication-title: Int. J. Cancer. doi: 10.1002/ijc.28146 – volume: 379 start-page: 1519 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0005 article-title: Effect of aspirin on all-cause mortality in the healthy elderly publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1803955 – volume: 23 start-page: 2619 year: 2019 ident: 10.1016/j.bcp.2020.113886_b0520 article-title: Paracellular and transcellular migration of metastatic cells through the cerebral endothelium publication-title: J. Cell. Mol. Med. doi: 10.1111/jcmm.14156 – volume: 8 start-page: 2239 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0480 article-title: The podoplanin-CLEC-2 axis inhibits inflammation in sepsis publication-title: Nat Commun. doi: 10.1038/s41467-017-02402-6 – volume: 108 start-page: 323 year: 1993 ident: 10.1016/j.bcp.2020.113886_b0595 article-title: Nitric oxide modulates vascular permeability in the rat coronary circulation publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.1993.tb12803.x – volume: 69 start-page: 5623 year: 2009 ident: 10.1016/j.bcp.2020.113886_b0340 article-title: Platelets: guardians of tumor vasculature publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-1370 – volume: 14 start-page: 645 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0460 article-title: Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development publication-title: J. Thromb. Haemost. doi: 10.1111/jth.13250 – volume: 331 start-page: 1559 year: 2011 ident: 10.1016/j.bcp.2020.113886_b0545 article-title: A perspective on cancer cell metastasis publication-title: Science doi: 10.1126/science.1203543 – volume: 61 start-page: 46 year: 1968 ident: 10.1016/j.bcp.2020.113886_b0145 article-title: Antimetastatic effects associated with platelet reduction publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.61.1.46 – volume: 72 start-page: 672 year: 2011 ident: 10.1016/j.bcp.2020.113886_b0415 article-title: Anti-platelet therapy: glycoprotein IIb-IIIa antagonists publication-title: British J. Clin. Pharmacol. doi: 10.1111/j.1365-2125.2010.03879.x – volume: 8 start-page: e73609 year: 2013 ident: 10.1016/j.bcp.2020.113886_b0500 article-title: Platelets promote tumor growth and metastasis via direct interaction between aggrus/podoplanin and CLEC-2 publication-title: PLoS One doi: 10.1371/journal.pone.0073609 – volume: 20 start-page: 445 year: 2013 ident: 10.1016/j.bcp.2020.113886_b0615 article-title: Platelet ITAM signaling publication-title: Curr. Opin. Hematol. doi: 10.1097/MOH.0b013e3283642267 – volume: 174 start-page: 51 year: 2019 ident: 10.1016/j.bcp.2020.113886_b0290 article-title: Risk of cancer after an acute coronary syndrome according to the type of P2Y12 inhibitor publication-title: Thromb. Res. doi: 10.1016/j.thromres.2018.12.014 – volume: 111 start-page: 4958 year: 2008 ident: 10.1016/j.bcp.2020.113886_b0425 article-title: Inflammation induces hemorrhage in thrombocytopenia publication-title: Blood doi: 10.1182/blood-2007-11-123620 – volume: 175 start-page: 1699 year: 2009 ident: 10.1016/j.bcp.2020.113886_b0455 article-title: Innate immune cells induce hemorrhage in tumors during thrombocytopenia publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2009.090460 – volume: 102 start-page: 449 year: 2003 ident: 10.1016/j.bcp.2020.113886_b0410 article-title: Platelet-collagen interaction: Is GPVI the central receptor? publication-title: Blood doi: 10.1182/blood-2002-12-3882 – volume: 240 start-page: 1031 year: 1949 ident: 10.1016/j.bcp.2020.113886_b0020 article-title: Migrating thrombophlebitis associated with carcinoma publication-title: N. Engl. J. Med. doi: 10.1056/NEJM194906302402601 – volume: 1 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0085 article-title: Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell-derived ADAM9 publication-title: JCI Insight. doi: 10.1172/jci.insight.88245 – volume: 33 start-page: 712 year: 2007 ident: 10.1016/j.bcp.2020.113886_b0105 article-title: Inhibition of platelet function: does it offer a chance of better cancer progression control? publication-title: Semin. Thromb. Hemost. doi: 10.1055/s-2007-991540 – volume: 11 start-page: 117 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0165 article-title: Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction publication-title: J. Hematol. Oncol. doi: 10.1186/s13045-018-0659-4 – volume: 12 start-page: dmm036269 issue: 3 year: 2019 ident: 10.1016/j.bcp.2020.113886_b0555 article-title: Early and late endothelial response in breast cancer metastasis in mice: simultaneous quantification of endothelial biomarkers using a mass spectrometry-based method publication-title: Dis. Model. Mech. doi: 10.1242/dmm.036269 – volume: 35 start-page: 3817 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0205 article-title: PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo publication-title: Oncogene doi: 10.1038/onc.2015.452 – volume: 114 start-page: 1714 year: 2004 ident: 10.1016/j.bcp.2020.113886_b0120 article-title: Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer publication-title: J. Clin. Invest. doi: 10.1172/JCI200422123 – volume: 123 start-page: 908 year: 2013 ident: 10.1016/j.bcp.2020.113886_b0430 article-title: Platelet ITAM signaling is critical for vascular integrity in infammation publication-title: J. Clin. Invest. – volume: 193 start-page: 459 year: 2001 ident: 10.1016/j.bcp.2020.113886_b0505 article-title: Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice publication-title: J. Exp. Med. doi: 10.1084/jem.193.4.459 – volume: 294 start-page: 47 year: 2005 ident: 10.1016/j.bcp.2020.113886_b0250 article-title: Low-dose aspirin in the primary prevention of cancer. The women’s health study: a randomized controlled trial publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.294.1.47 – volume: 122 start-page: 3405 year: 2013 ident: 10.1016/j.bcp.2020.113886_b0375 article-title: Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation publication-title: Blood doi: 10.1182/blood-2013-05-504449 – volume: 20 start-page: 86 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0530 article-title: Nitric oxide deficiency and endothelial-mesenchymal transition of pulmonary endothelium in the progression of 4T1 metastatic breast cancer in mice publication-title: Breast Cancer Res. doi: 10.1186/s13058-018-1013-z – volume: 9 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0115 article-title: The role of platelet-derived ADP and ATP in promoting pancreatic cancer cell survival and gemcitabine resistance publication-title: Cancers (Basel) doi: 10.3390/cancers9100142 – volume: 254 start-page: H763 year: 1988 ident: 10.1016/j.bcp.2020.113886_b0540 article-title: Role of platelets in maintenance of pulmonary vascular permeability to protein publication-title: Am. J. Physiol. - Hear. Circ. Physiol. doi: 10.1152/ajpheart.1988.254.4.H763 – volume: 11 year: 2019 ident: 10.1016/j.bcp.2020.113886_b0210 article-title: Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aau5898 – volume: 35 start-page: 24 year: 2015 ident: 10.1016/j.bcp.2020.113886_b0605 article-title: Targeting integrin and integrin signaling in treating thrombosis publication-title: Arterioscler. Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.114.303411 – volume: 100 start-page: 1673 year: 2007 ident: 10.1016/j.bcp.2020.113886_b0405 article-title: Adhesion mechanisms in platelet function publication-title: Circ. Res. doi: 10.1161/01.RES.0000267878.97021.ab – volume: 157 start-page: 112 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0050 article-title: Involvement of platelets in tumor cell metastasis publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2015.11.005 – volume: 129 start-page: 1845 year: 2019 ident: 10.1016/j.bcp.2020.113886_b0220 article-title: Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2 publication-title: J. Clin. Invest. doi: 10.1172/JCI121985 – volume: 102 start-page: 216 year: 2005 ident: 10.1016/j.bcp.2020.113886_b0140 article-title: Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0406682102 – volume: 22 start-page: 1349 year: 2001 ident: 10.1016/j.bcp.2020.113886_b0195 article-title: 12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells publication-title: Carcinogenesis doi: 10.1093/carcin/22.9.1349 – volume: 129 start-page: 1702 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0435 article-title: Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice publication-title: Blood doi: 10.1182/blood-2016-12-750711 – volume: 69 start-page: 7775 year: 2009 ident: 10.1016/j.bcp.2020.113886_b0040 article-title: Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-2123 – volume: 33 start-page: 965 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0035 article-title: The platelet lifeline to cancer: challenges and opportunities publication-title: Cancer Cell. doi: 10.1016/j.ccell.2018.03.002 – volume: 68 start-page: 6851 year: 2008 ident: 10.1016/j.bcp.2020.113886_b0450 article-title: Platelet granule secretion continuously prevents intratumor hemorrhage publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-0718 – volume: 110 start-page: 1903 year: 2007 ident: 10.1016/j.bcp.2020.113886_b0485 article-title: Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge publication-title: Blood doi: 10.1182/blood-2007-03-081901 – volume: 7 start-page: 1595 year: 2009 ident: 10.1016/j.bcp.2020.113886_b0200 article-title: Long-term thrombin inhibition promotes cancer cell extravasation in a mouse model of experimental metastasis publication-title: J. Thromb. Haemost. doi: 10.1111/j.1538-7836.2009.03529.x – volume: 76 start-page: 5302 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0475 article-title: Monocyte induction of E-selectin-mediated endothelial activation releases VE-cadherin junctions to promote tumor cell extravasation in the metastasis cascade publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-16-0784 – volume: 11 start-page: E100 issue: pii year: 2019 ident: 10.1016/j.bcp.2020.113886_b0295 article-title: Thrombin generation and cancer: contributors and consequences publication-title: Cancers (Basel). doi: 10.3390/cancers11010100 – volume: 92 start-page: 639 year: 1987 ident: 10.1016/j.bcp.2020.113886_b9000 article-title: The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.1987.tb11367.x – volume: 92 start-page: 689 year: 1964 ident: 10.1016/j.bcp.2020.113886_b0025 article-title: Recurrent and migratory venous thromboses publication-title: Prog. Med. (Paris) – volume: 102 start-page: S2 year: 2010 ident: 10.1016/j.bcp.2020.113886_b0030 article-title: Epidemiology and pathophysiology of cancer-associated thrombosis publication-title: Br. J. Cancer. doi: 10.1038/sj.bjc.6605599 – volume: 21 start-page: 85 year: 2010 ident: 10.1016/j.bcp.2020.113886_b0320 article-title: The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets publication-title: Platelets doi: 10.3109/09537100903470298 – volume: 42 start-page: 5 year: 2005 ident: 10.1016/j.bcp.2020.113886_b0400 article-title: New perspectives on von Willebrand factor functions in hemostasis and thrombosis publication-title: Semin. Hematol. doi: 10.1053/j.seminhematol.2004.09.006 – volume: 133 start-page: 2696 year: 2019 ident: 10.1016/j.bcp.2020.113886_b0170 article-title: Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice publication-title: Blood doi: 10.1182/blood.2018877043 – volume: 2 start-page: 1416 year: 1972 ident: 10.1016/j.bcp.2020.113886_b0275 article-title: Aspirin and tumour metastasis publication-title: Lancet (London, England) doi: 10.1016/S0140-6736(72)92982-0 – volume: 11 start-page: e0152402 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0260 article-title: Aspirin in the treatment of cancer: reductions in metastatic spread and in mortality: a systematic review and meta-analyses of published studies publication-title: PLoS One doi: 10.1371/journal.pone.0152402 – volume: 25 start-page: 210 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0395 article-title: Spontaneous bleeding in thrombocytopenia: is it really spontaneous? publication-title: Transfus. Clin. Biol. doi: 10.1016/j.tracli.2018.06.005 – volume: 118 start-page: 1464 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0570 article-title: Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover publication-title: Br. J. Cancer. doi: 10.1038/s41416-018-0110-1 – volume: 10 start-page: 269 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0560 article-title: Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: role of Rac and PI3K publication-title: Cell Adh. Migr. doi: 10.1080/19336918.2015.1122156 – volume: 81 start-page: 505 year: 2019 ident: 10.1016/j.bcp.2020.113886_b0355 article-title: Normalizing function of tumor vessels: progress, opportunities, and challenges publication-title: Annu. Rev. Physiol. doi: 10.1146/annurev-physiol-020518-114700 – volume: 9 start-page: E94 issue: pii year: 2017 ident: 10.1016/j.bcp.2020.113886_b0070 article-title: Targeting platelets for the treatment of cancer publication-title: Cancers (Basel) doi: 10.3390/cancers9070094 – volume: 281 start-page: 26665 year: 2006 ident: 10.1016/j.bcp.2020.113886_b0315 article-title: PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M602174200 – volume: 115 start-page: 3427 year: 2010 ident: 10.1016/j.bcp.2020.113886_b0155 article-title: Deadly allies: the fatal interplay between platelets and metastasizing cancer cells publication-title: Blood doi: 10.1182/blood-2009-10-247296 – volume: 1 start-page: 8 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0190 article-title: Inhibiting breast cancer by targeting the thromboxane A2 pathway publication-title: Npj Precis. Oncol. doi: 10.1038/s41698-017-0011-4 – volume: 1 start-page: 103 year: 1983 ident: 10.1016/j.bcp.2020.113886_b0185 article-title: Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin/thromboxane A2 system publication-title: Clin. Exp. Metastasis doi: 10.1007/BF00121490 – volume: 35 start-page: 324 year: 2014 ident: 10.1016/j.bcp.2020.113886_b0100 article-title: Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway publication-title: Carcinogenesis doi: 10.1093/carcin/bgt332 – volume: 80 start-page: 291 year: 2019 ident: 10.1016/j.bcp.2020.113886_b0360 article-title: The interaction of platelets with colorectal cancer cells inhibits tumor growth but promotes metastasis publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-19-1181 – volume: 502 start-page: 105 year: 2013 ident: 10.1016/j.bcp.2020.113886_b0445 article-title: Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2 publication-title: Nature doi: 10.1038/nature12501 – volume: 9 start-page: 56 year: 2011 ident: 10.1016/j.bcp.2020.113886_b0535 article-title: How platelets safeguard vascular integrity publication-title: J. Thromb. Haemost. doi: 10.1111/j.1538-7836.2011.04317.x – volume: 275 start-page: H1054 year: 1998 ident: 10.1016/j.bcp.2020.113886_b0370 article-title: In vitro release of vascular endothelial growth factor during platelet aggregation publication-title: Am. J. Physiol. - Hear. Circ. Physiol. doi: 10.1152/ajpheart.1998.275.3.H1054 – volume: 76 start-page: 199 year: 1995 ident: 10.1016/j.bcp.2020.113886_b0590 article-title: cGMP and nitric oxide modulate thrombin-induced endothelial permeability: regulation via different pathways in human aortic and umbilical vein endothelial cells publication-title: Circ. Res. doi: 10.1161/01.RES.76.2.199 – volume: 84 start-page: 25 year: 2013 ident: 10.1016/j.bcp.2020.113886_b0125 article-title: Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cellss publication-title: Mol. Pharmacol. doi: 10.1124/mol.113.084988 – volume: 2015 start-page: 778 year: 1852 ident: 10.1016/j.bcp.2020.113886_b0600 article-title: Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1 publication-title: Biochim. Biophys. Acta – volume: 143 start-page: 1713 year: 1993 ident: 10.1016/j.bcp.2020.113886_b0060 article-title: Protection from tumor necrosis factor-mediated cytolysis by platelets publication-title: Am J Pathol. – volume: 131 start-page: 1777 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0045 article-title: Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents publication-title: Blood doi: 10.1182/blood-2017-05-743187 – volume: 24 start-page: 130 year: 2013 ident: 10.1016/j.bcp.2020.113886_b0080 article-title: Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor publication-title: Cancer Cell. doi: 10.1016/j.ccr.2013.05.008 – volume: 9 start-page: 345 year: 2015 ident: 10.1016/j.bcp.2020.113886_b0550 article-title: Metastasis of circulating tumor cells: Favorable soil or suitable biomechanics, or both? publication-title: Cell Adhes. Migr. doi: 10.1080/19336918.2015.1059563 – volume: 112 start-page: 4086 year: 2015 ident: 10.1016/j.bcp.2020.113886_b0580 article-title: Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1417273112 – volume: 28 start-page: 427 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0160 article-title: Sulfated fucans and a sulfated galactan from sea urchins as potent inhibitors of selectin-dependent hematogenous metastasis publication-title: Glycobiology doi: 10.1093/glycob/cwy020 – volume: 16 start-page: 1802 year: 2015 ident: 10.1016/j.bcp.2020.113886_b0240 article-title: Thrombin inhibition and cyclophosphamide synergistically block tumor progression and metastasis publication-title: Cancer Biol. Ther. doi: 10.1080/15384047.2015.1078025 – volume: 167 start-page: 787 year: 2012 ident: 10.1016/j.bcp.2020.113886_b0075 article-title: Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2012.01991.x – volume: 22 start-page: 4923 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0565 article-title: BCAM and LAMA5 mediate the recognition between tumor cells and the endothelium in the metastatic spreading of KRAS-mutant colorectal cancer publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-15-2664 – volume: 11 start-page: 704 year: 1973 ident: 10.1016/j.bcp.2020.113886_b0150 article-title: Platelet-tumor-cell interactions in mice. The role of platelets in the spread of malignant disease publication-title: Int. J. Cancer doi: 10.1002/ijc.2910110322 – volume: 111 start-page: E3053 year: 2014 ident: 10.1016/j.bcp.2020.113886_b0135 article-title: Platelets guide the formation of early metastatic niches publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1411082111 – volume: 315 start-page: 2564 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0285 article-title: Screening for colorectal cancer: US preventive services task force recommendation statement publication-title: JAMA - J. Am. Med. Assoc. doi: 10.1001/jama.2016.5989 – volume: 7 start-page: 770 year: 2015 ident: 10.1016/j.bcp.2020.113886_b0585 article-title: Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2 publication-title: EMBO Mol. Med. doi: 10.15252/emmm.201404193 – volume: 59 start-page: 1295 year: 1999 ident: 10.1016/j.bcp.2020.113886_b0065 article-title: Lysis of tumor cells by natural killer cells in mice is impeded by platelets publication-title: Cancer Res. – volume: 33 start-page: 11 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0515 article-title: Underlying mechanisms for distant metastasis - molecular biology publication-title: Visc. Med. doi: 10.1159/000454696 – volume: 93 start-page: 327 year: 2013 ident: 10.1016/j.bcp.2020.113886_b0420 article-title: New fundamentals in hemostasis publication-title: Physiol. Rev. doi: 10.1152/physrev.00016.2011 – volume: 9 start-page: 17810 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0265 article-title: Dual antiplatelet therapy with clopidogrel and aspirin increases mortality in 4T1 metastatic breast cancer-bearing mice by inducing vascular mimicry in primary tumour publication-title: Oncotarget doi: 10.18632/oncotarget.24891 – volume: 13 start-page: 518 year: 2012 ident: 10.1016/j.bcp.2020.113886_b0235 article-title: Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials publication-title: Lancet. Oncol. doi: 10.1016/S1470-2045(12)70112-2 – volume: 94 start-page: 2832 year: 2008 ident: 10.1016/j.bcp.2020.113886_b0345 article-title: Breakdown of the endothelial barrier function in tumor cell transmigration publication-title: Biophys. J. doi: 10.1529/biophysj.107.113613 – volume: 33 start-page: 231 year: 2014 ident: 10.1016/j.bcp.2020.113886_b0015 article-title: Platelets and cancer: a casual or causal relationship: revisited publication-title: Cancer Metastasis Rev. doi: 10.1007/s10555-014-9498-0 – volume: 212 start-page: 1255 year: 2015 ident: 10.1016/j.bcp.2020.113886_b0385 article-title: Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia publication-title: J. Exp. Med. doi: 10.1084/jem.20142076 – volume: 77 start-page: 1942 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0270 article-title: Role of megakaryocytes in breast cancer metastasis to bone publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-16-1084 – volume: 7 start-page: 4059 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0495 article-title: Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation publication-title: Sci. Rep. doi: 10.1038/s41598-017-04324-1 – volume: 376 start-page: 1741 year: 2010 ident: 10.1016/j.bcp.2020.113886_b0225 article-title: Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials publication-title: Lancet doi: 10.1016/S0140-6736(10)61543-7 – volume: 5 start-page: 5256 year: 2014 ident: 10.1016/j.bcp.2020.113886_b0090 article-title: Platelets promote tumour metastasis via interaction between TLR4 and tumour cell-released high-mobility group box1 protein publication-title: Nat. Commun. doi: 10.1038/ncomms6256 – volume: 8 start-page: 110994 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0175 article-title: C3G promotes a selective release of angiogenic factors from activated mouse platelets to regulate angiogenesis and tumor metastasis publication-title: Oncotarget doi: 10.18632/oncotarget.22339 – volume: 105 start-page: 3178 year: 2005 ident: 10.1016/j.bcp.2020.113886_b0300 article-title: Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation publication-title: Blood doi: 10.1182/blood-2004-10-3985 – volume: 29 start-page: 549 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0390 article-title: Platelets and vascular integrity publication-title: Platelets doi: 10.1080/09537104.2018.1428739 – volume: 114 start-page: 3464 year: 2009 ident: 10.1016/j.bcp.2020.113886_b0610 article-title: CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis publication-title: Blood doi: 10.1182/blood-2009-05-222273 – volume: 359 start-page: 1261 year: 2008 ident: 10.1016/j.bcp.2020.113886_b0325 article-title: Platelets, petechiae, and preservation of the vascular wall publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0800887 – volume: 18 start-page: 582 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0525 article-title: Alterations in NO- and PGI2- dependent function in aorta in the orthotopic murine model of metastatic 4T1 breast cancer: relationship with pulmonary endothelial dysfunction and systemic inflammation publication-title: BMC Cancer doi: 10.1186/s12885-018-4445-z – volume: 98 start-page: 989 year: 2008 ident: 10.1016/j.bcp.2020.113886_b0255 article-title: Low-dose aspirin and breast cancer risk: results by tumour characteristics from a randomised trial publication-title: Br. J. Cancer. doi: 10.1038/sj.bjc.6604240 – volume: 292 start-page: 14516 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0510 article-title: Gq pathway regulates proximal C-type lectin-like receptor-2 (CLEC-2) signaling in platelets publication-title: J. Biol. Chem. doi: 10.1074/jbc.M117.791012 – volume: 8 start-page: e55740 year: 2013 ident: 10.1016/j.bcp.2020.113886_b0310 article-title: Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets publication-title: PLoS One. doi: 10.1371/journal.pone.0055740 – volume: 129 start-page: 2013 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0490 article-title: Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis publication-title: Blood doi: 10.1182/blood-2016-09-742999 – volume: 51 start-page: 56 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0280 article-title: Add-Aspirin investigators, ADD-ASPIRIN: a phase III, double-blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours publication-title: Contemp. Clin. Trials doi: 10.1016/j.cct.2016.10.004 – volume: 79 start-page: 56 year: 2010 ident: 10.1016/j.bcp.2020.113886_b0575 article-title: ANP attenuates inflammatory signaling and Rho pathway of lung endothelial permeability induced by LPS and TNFalpha publication-title: Microvasc. Res. doi: 10.1016/j.mvr.2009.11.006 – volume: 130 start-page: 1235 year: 2017 ident: 10.1016/j.bcp.2020.113886_b0130 article-title: Role of ADP receptors on platelets in the growth of ovarian cancer publication-title: Blood doi: 10.1182/blood-2017-02-769893 – volume: 10 start-page: 1001 year: 2010 ident: 10.1016/j.bcp.2020.113886_b0215 article-title: Use of dabigatran etexilate to reduce breast cancer progression publication-title: Cancer Biol. Ther. doi: 10.4161/cbt.10.10.13236 – volume: 219 start-page: 744 year: 2009 ident: 10.1016/j.bcp.2020.113886_b0305 article-title: Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 kinase publication-title: J. Cell. Physiol. doi: 10.1002/jcp.21718 – volume: 377 start-page: 31 year: 2011 ident: 10.1016/j.bcp.2020.113886_b0230 article-title: Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials publication-title: Lancet doi: 10.1016/S0140-6736(10)62110-1 – volume: 23 start-page: 808 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0095 article-title: Platelets promote metastasis via binding tumor CD97 leading to bidirectional signaling that coordinates transendothelial migration publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.03.092 – volume: 134 start-page: 47 year: 2018 ident: 10.1016/j.bcp.2020.113886_b0180 article-title: Iloprost, a prostacyclin analog, inhibits the invasion of ovarian cancer cells by downregulating matrix metallopeptidase-2 (MMP-2) through the IP-dependent pathway publication-title: Prostaglandins Other Lipid Mediat. doi: 10.1016/j.prostaglandins.2017.12.002 – volume: 14 start-page: 27 year: 2016 ident: 10.1016/j.bcp.2020.113886_b0465 article-title: New horizon in platelet function: with special reference to a recently-found molecule, CLEC-2 publication-title: Thromb. J. doi: 10.1186/s12959-016-0099-8 |
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Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet–cancer cell interactions linked... Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet-cancer cell interactions linked to thrombotic... |
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| SubjectTerms | Cancer metastasis Inflammation-associated hemostasis Platelet inhibition Platelet-cancer cell interaction |
| Title | The endothelial barrier and cancer metastasis: Does the protective facet of platelet function matter? |
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