The endothelial barrier and cancer metastasis: Does the protective facet of platelet function matter?
[Display omitted] Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet–cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory c...
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| Vydáno v: | Biochemical pharmacology Ročník 176; s. 113886 |
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| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
Elsevier Inc
01.06.2020
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| Témata: | |
| ISSN: | 0006-2952, 1873-2968, 1873-2968 |
| On-line přístup: | Získat plný text |
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| Shrnutí: | [Display omitted]
Overwhelming evidence suggests that platelets have a detrimental role in promoting cancer spread via platelet–cancer cell interactions linked to thrombotic mechanisms. On the other hand, a beneficial role of platelets in the preservation of the endothelial barrier in inflammatory conditions has been recently described, a phenomenon that could also operate in cancer–related inflammation. It is tempting to speculate that some antiplatelet strategies to combat cancer metastasis may impair the endogenous platelet–dependent mechanisms preserving endothelial barrier function. If the protective function of platelets is impaired, it may lead to increased endothelial permeability and more efficient cancer cell intravasation in the primary tumor and cancer cell extravasation at metastatic sites. In this commentary, we discuss current evidence that could support this hypothesis. |
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| Bibliografie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ISSN: | 0006-2952 1873-2968 1873-2968 |
| DOI: | 10.1016/j.bcp.2020.113886 |