Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2

Endothelial dysfunction contributes significantly to acute renal failure (ARF) during inflammatory diseases including septic shock. Previous studies have shown that activated protein C (APC) exhibits anti-inflammatory properties and modulates endothelial function. Therefore, we investigated the effe...

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Veröffentlicht in:	American journal of physiology. Renal physiology Jg. 293; H. 1; S. F245
Hauptverfasser:	Gupta, Akanksha, Rhodes, George J, Berg, David T, Gerlitz, Bruce, Molitoris, Bruce A, Grinnell, Brian W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2007
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - pathology Acute Kidney Injury - prevention & control Angiotensin II - antagonists & inhibitors Angiotensin II - biosynthesis Animals Blood Urea Nitrogen Cell Adhesion - drug effects Down-Regulation - drug effects Endotoxemia - metabolism Endotoxemia - pathology Kidney - drug effects Kidney - metabolism Kidney - pathology Leukocytes - drug effects Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - toxicity Macrophage Activation - drug effects Male Nitric Oxide - metabolism Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - biosynthesis Protein C - pharmacology Rats Rats, Sprague-Dawley Renal Circulation - drug effects Renin-Angiotensin System - drug effects Reverse Transcriptase Polymerase Chain Reaction Urea - blood Vasoconstriction - drug effects Vasodilation - drug effects
ISSN:	1931-857X
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