An Improved Multi-parametric Programming Algorithm for Flux Balance Analysis of Metabolic Networks

Flux balance analysis has proven an effective tool for analyzing metabolic networks. In flux balance analysis, reaction rates and optimal pathways are ascertained by solving a linear program, in which the growth rate is maximized subject to mass-balance constraints. A variety of cell functions in re...

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Bibliographic Details
Published in:	Journal of optimization theory and applications Vol. 178; no. 2; pp. 502 - 537
Main Authors:	Akbari, Amir, Barton, Paul I.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.08.2018 Springer Nature B.V
Subjects:	Algorithms Applications of Mathematics Calculus of Variations and Optimal Control; Optimization Computation E coli Engineering Flux Genomes Linear algebra Linear programming Mathematics Mathematics and Statistics Matrix methods Metabolism Networks Operations Research/Decision Theory Optimization Scale models Software Space bases Stoichiometry Theory of Computation 90C20 90C06 Multi-parametric programming Flux balance analysis 90C05 Metabolic networks
ISSN:	0022-3239, 1573-2878
Online Access:	Get full text
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