MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression

Colorectal cancer (CRC) is one of the most common cancers worldwide, especially in Western countries. Although chemotherapy is used as an adjuvant or as a palliative treatment, drug resistance poses a great challenge. This study intended to identify biomarkers as predictive factors for chemotherapy....

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Veröffentlicht in:	Oncotarget Jg. 5; H. 10; S. 2974
Hauptverfasser:	Fang, Lekun, Li, Haoran, Wang, Lei, Hu, Jun, Jin, Tianru, Wang, Jianping, Yang, Burton B
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 30.05.2014
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Blotting, Western Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Drug Resistance, Neoplasm - genetics Female Flow Cytometry Gene Expression Regulation, Neoplastic - genetics Humans Immunohistochemistry In Situ Hybridization Kaplan-Meier Estimate Male MicroRNAs - genetics Middle Aged Neoplasm Metastasis - genetics Oligonucleotide Array Sequence Analysis Prognosis PTEN Phosphohydrolase - biosynthesis Real-Time Polymerase Chain Reaction Tissue Array Analysis Transfection
ISSN:	1949-2553, 1949-2553
Online-Zugang:	Weitere Angaben
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