Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial

Biliary tract cancers, which arise from the intrahepatic or extrahepatic bile ducts and the gallbladder, generally have a poor prognosis and are rising in incidence worldwide. The standard-of-care treatment for advanced biliary tract cancer is chemotherapy with gemcitabine and cisplatin. Because mos...

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Veröffentlicht in:	The Lancet (British edition) Jg. 401; H. 10391; S. 1853 - 1865
Hauptverfasser:	Ueno, Makoto, Finn, Richard S, Ren, Zhenggang, Yau, Thomas, Klümpen, Heinz-Josef, Chan, Stephen L, Park, Joon Oh, Pelzer, Uwe, Yu, Li, Siegel, Abby B, Edeline, Julien, Akce, Mehmet, Asselah, Jamil, Assenat, Eric, Aubin, Francine, Barajas, Olga, Ben-Aharon, Irit, Beri, Nina, Berres, Marie-Luise, Brandi, Giovanni, Butthongkomvong, Kritiya, Camandaroba, Marcos, Carballido, Marcela, Chan, Stephan Lam, Chen, Jen-Shi, Chen, Xiaoming, Chon, Hong Jae, Cubillo Gracian, Antonio, Davis, Sarah, De Vos, Judith, Falcone, Alfredo, Fernandez, Plinio, Finn, Richard, Franke, Fabio, Furukawa, Masayuki, Furuse, Junji, Geboes, Karen, Geng, Zhimin, Geva, Ravit, Gou, Hongfeng, Grasselli, Julieta, Hao, Chunyi, Hatoum, Hassan, Heinemann, Volker, Jeyasingam, Vaishnavi, Jimenez Fonseca, Paula, Kasper-Virchow, Stefan, Kelley, Robin, Kim, Jong Gwang, Kinupe Abrahao, Ana Beatriz, Kochenderfer, Mark, Lee, Choong-kun, Lee, Hyun Woo, Lee, Myung Ah, Lee, Wai Man Sarah, Li, Dongliang, Liang, Houjie, Lim, Chun Sen, Low, John, Mao, Yimin, Masi, Gianluca, McCune, Steven, McWhirter, Elaine, Mendez, Guillermo, Mizutani, Tomonori, Moniz, Camila, Morales, Luisa, Munoz Martin, Andres Jesús, Oh, Sang Cheul, Painemal, Claudio, Peng, Chuang, Pezet, Denis, Roohullah, Aflah, Ryu, Hyewon, Schulze, Kornelius, Scott-Brown, Martin, Seufferlein, Thomas, Smolenschi, Cristina, Sookprasert, Aumkhae, Soparattanapaisarn, Nopadol, Starling, Naureen, Stein, Stacey, Sugimoto, Rie, Suksombooncharoen, Thatthan, Tam, Vincent, Tan, Ai Lian, Tanasanvimon, Suebpong, Tonini, Giuseppe, Tsuji, Akihito, Verslype, Chris, Victorino, Ana Paula, Wade, James, Waldschmidt, Dirk Thomas, Wang, Lu, Wan Isahk, Wan Zamaniah, Weschenfelder, Rui, Wong, Chun Yin, Yang, Xuezhong, Zhao, Haitao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 03.06.2023 Elsevier Limited Elsevier
Schlagworte:	Adverse events Antibodies Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bile ducts Biliary tract Biliary tract diseases Biliary Tract Neoplasms - drug therapy Biliary Tract Neoplasms - pathology Biomarkers Cancer Cancer therapies Chemotherapy Cholangiocarcinoma Cisplatin Consent Double-Blind Method Double-blind studies Gallbladder Gallbladder cancer Gemcitabine Health care facilities Health services Hepatitis B Hepatitis C Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - therapeutic use Immunotherapy Inhibitors Interactive systems Life Sciences Medical prognosis Metastases Metastasis Microenvironments Monoclonal antibodies Patients Pembrolizumab Placebos Population studies Randomization Safety Solid tumors Statistical analysis Survival Targeted cancer therapy Tumor Microenvironment Asia United States > US
ISSN:	0140-6736, 1474-547X, 1474-547X
Online-Zugang:	Volltext
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