Impact of daily-supervised administration of a package of iron and folic acid and vitamin B12 on hemoglobin levels among adolescent girls (12–19 years): a cluster randomized control trial
ObjectiveThe prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B12 on hemoglobin lev...
Saved in:
| Published in: | European journal of clinical nutrition Vol. 75; no. 11; pp. 1588 - 1597 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
Nature Publishing Group
01.11.2021
|
| Subjects: | |
| ISSN: | 0954-3007, 1476-5640, 1476-5640 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | ObjectiveThe prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B12 on hemoglobin levels among adolescent girls.MethodsA community-based cluster-randomized trial was conducted in the rural block of Faridabad District, Haryana, India in the year 2017. A total of 760 adolescent girls in the age group of 12–19 years with mild and moderate anemia were selected from government schools. Daily-supervised administration of iron and folic acid was conducted for 90 days: experimental group—IFA (iron (60 mg), folic acid (500) mcg), and cyanocobalamin (1000 mcg), control group—IFA and placebo. Hemoglobin, serum ferritin, and vitamin B12 levels were assessed at baseline and endline.ResultsTwo-hundred adolescent girls completed 90 doses of daily supplementation. The mean hemoglobin (experimental group: 1.3 ± 1.0 g/dL, control group: 1.6 ± 1.2 g/dL, P = 0.004) and ferritin levels (experimental group: 18.6 ± 31.5 ng/mL, control group: 18.8 ± 35.0 ng/mL, P = 0.188) increased in both the control and experiment groups. Serum vitamin B12 deficiency significantly reduced to 2.5% in the experimental group and ferritin deficiency alleviated in more than 96% of the girls post intervention.ConclusionsDaily supplementation of IFA with/without vitamin B12 for 90 days eliminated iron, vitamin B12 deficiency and reduced the overall proportion of anemia by 53.5%. However, addition of vitamin B12 to IFA supplementation had no impact on improving the hemoglobin levels among adolescent girls. The present study does not recommend provision of vitamin B12 for prevention and treatment of anemia in this population group. |
|---|---|
| AbstractList | ObjectiveThe prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B12 on hemoglobin levels among adolescent girls.MethodsA community-based cluster-randomized trial was conducted in the rural block of Faridabad District, Haryana, India in the year 2017. A total of 760 adolescent girls in the age group of 12–19 years with mild and moderate anemia were selected from government schools. Daily-supervised administration of iron and folic acid was conducted for 90 days: experimental group—IFA (iron (60 mg), folic acid (500) mcg), and cyanocobalamin (1000 mcg), control group—IFA and placebo. Hemoglobin, serum ferritin, and vitamin B12 levels were assessed at baseline and endline.ResultsTwo-hundred adolescent girls completed 90 doses of daily supplementation. The mean hemoglobin (experimental group: 1.3 ± 1.0 g/dL, control group: 1.6 ± 1.2 g/dL, P = 0.004) and ferritin levels (experimental group: 18.6 ± 31.5 ng/mL, control group: 18.8 ± 35.0 ng/mL, P = 0.188) increased in both the control and experiment groups. Serum vitamin B12 deficiency significantly reduced to 2.5% in the experimental group and ferritin deficiency alleviated in more than 96% of the girls post intervention.ConclusionsDaily supplementation of IFA with/without vitamin B12 for 90 days eliminated iron, vitamin B12 deficiency and reduced the overall proportion of anemia by 53.5%. However, addition of vitamin B12 to IFA supplementation had no impact on improving the hemoglobin levels among adolescent girls. The present study does not recommend provision of vitamin B12 for prevention and treatment of anemia in this population group. The prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B12 on hemoglobin levels among adolescent girls.OBJECTIVEThe prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B12 on hemoglobin levels among adolescent girls.A community-based cluster-randomized trial was conducted in the rural block of Faridabad District, Haryana, India in the year 2017. A total of 760 adolescent girls in the age group of 12-19 years with mild and moderate anemia were selected from government schools. Daily-supervised administration of iron and folic acid was conducted for 90 days: experimental group-IFA (iron (60 mg), folic acid (500) mcg), and cyanocobalamin (1000 mcg), control group-IFA and placebo. Hemoglobin, serum ferritin, and vitamin B12 levels were assessed at baseline and endline.METHODSA community-based cluster-randomized trial was conducted in the rural block of Faridabad District, Haryana, India in the year 2017. A total of 760 adolescent girls in the age group of 12-19 years with mild and moderate anemia were selected from government schools. Daily-supervised administration of iron and folic acid was conducted for 90 days: experimental group-IFA (iron (60 mg), folic acid (500) mcg), and cyanocobalamin (1000 mcg), control group-IFA and placebo. Hemoglobin, serum ferritin, and vitamin B12 levels were assessed at baseline and endline.Two-hundred adolescent girls completed 90 doses of daily supplementation. The mean hemoglobin (experimental group: 1.3 ± 1.0 g/dL, control group: 1.6 ± 1.2 g/dL, P = 0.004) and ferritin levels (experimental group: 18.6 ± 31.5 ng/mL, control group: 18.8 ± 35.0 ng/mL, P = 0.188) increased in both the control and experiment groups. Serum vitamin B12 deficiency significantly reduced to 2.5% in the experimental group and ferritin deficiency alleviated in more than 96% of the girls post intervention.RESULTSTwo-hundred adolescent girls completed 90 doses of daily supplementation. The mean hemoglobin (experimental group: 1.3 ± 1.0 g/dL, control group: 1.6 ± 1.2 g/dL, P = 0.004) and ferritin levels (experimental group: 18.6 ± 31.5 ng/mL, control group: 18.8 ± 35.0 ng/mL, P = 0.188) increased in both the control and experiment groups. Serum vitamin B12 deficiency significantly reduced to 2.5% in the experimental group and ferritin deficiency alleviated in more than 96% of the girls post intervention.Daily supplementation of IFA with/without vitamin B12 for 90 days eliminated iron, vitamin B12 deficiency and reduced the overall proportion of anemia by 53.5%. However, addition of vitamin B12 to IFA supplementation had no impact on improving the hemoglobin levels among adolescent girls. The present study does not recommend provision of vitamin B12 for prevention and treatment of anemia in this population group.CONCLUSIONSDaily supplementation of IFA with/without vitamin B12 for 90 days eliminated iron, vitamin B12 deficiency and reduced the overall proportion of anemia by 53.5%. However, addition of vitamin B12 to IFA supplementation had no impact on improving the hemoglobin levels among adolescent girls. The present study does not recommend provision of vitamin B12 for prevention and treatment of anemia in this population group. |
| Author | Gupta Aakriti Kapil Umesh Ramakrishnan Lakshmy Khandelwal Ritika Kant Shashi Sachdev Harshpal Singh Pandey, Ravindra Mohan |
| Author_xml | – sequence: 1 fullname: Gupta Aakriti – sequence: 2 fullname: Kant Shashi – sequence: 3 fullname: Ramakrishnan Lakshmy – sequence: 4 givenname: Ravindra surname: Pandey middlename: Mohan fullname: Pandey, Ravindra Mohan – sequence: 5 fullname: Khandelwal Ritika – sequence: 6 fullname: Kapil Umesh – sequence: 7 fullname: Sachdev Harshpal Singh |
| BookMark | eNpdkU1uFDEQhS0UJCaBC7CyxCYsDP5pd9vsIOInUiQ2sI7cdvXg4LYH2z1SWOUOnIfLcBIqwIpVqV599epJdUpOcslAyFPBXwiuzMs2iEFxxqVgnJvJsPEB2YlhGpkeB35CdtzqgSnOp0fktLUbznE4yR35ebkenO-0LDS4mG5Z2w5Qj7FBoC6sMcfWq-ux5HvEUYS_uj3cN7Gi6HKgS0nRU-dj-NMeY3e4SN8ISZH4AmvZpzKjkuAIqVG3lrxH95Kgecid7mNF-VzIX3c_hKW34Gp7_gqv-bS1DpVW9C1r_I6hfMm9lkR7jS49Jg8Xlxo8-VfPyOd3bz9dfGBXH99fXry-Yl7ZsTMn9bA40BxmIxcbNPggZJiGYCeQOFHBWDfP82ikNVots8ZiIMzCj0FpdUbO__oeavm2QevXa8ToKbkMZWvXUgsuNdd8RPTZf-hN2WrGdEhZYUZl8VW_AcgRibo |
| CitedBy_id | crossref_primary_10_1038_s41430_023_01308_5 crossref_primary_10_4081_jphia_2023_2548 crossref_primary_10_1038_s41430_022_01169_4 crossref_primary_10_1097_MCO_0000000000001027 crossref_primary_10_1007_s12288_023_01707_5 crossref_primary_10_1007_s12291_024_01228_6 |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Nature Limited 2021. 2021. The Author(s), under exclusive licence to Springer Nature Limited. |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Nature Limited 2021. – notice: 2021. The Author(s), under exclusive licence to Springer Nature Limited. |
| DBID | 3V. 7QP 7RV 7TK 7X2 7X7 7XB 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AN0 ATCPS AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K9. KB0 LK8 M0K M0S M1P M2O M7P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 |
| DOI | 10.1038/s41430-021-00878-6 |
| DatabaseName | ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Nursing & Allied Health Database Neurosciences Abstracts Agricultural Science Collection ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database ProQuest SciTech Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland British Nursing Database Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Biological Sciences Agriculture Science Database ProQuest Health & Medical Collection PML(ProQuest Medical Library) ProQuest Research Library Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic |
| DatabaseTitle | Agricultural Science Database Research Library Prep ProQuest Central Student ProQuest Central Essentials SciTech Premium Collection ProQuest Central China ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Agricultural & Environmental Science Collection ProQuest Research Library ProQuest Public Health ProQuest Central Basic British Nursing Index with Full Text ProQuest Nursing & Allied Health Source ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Diet & Clinical Nutrition |
| EISSN | 1476-5640 |
| EndPage | 1597 |
| GroupedDBID | --- -ET 0R~ 29G 36B 3V. 4.4 406 5GY 5RE 6PF 70F 7QP 7RV 7TK 7X2 7X7 7XB 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8FK 8G5 8R4 8R5 A8Z AACDK AAHBH AAIKC AAMNW AANZL AASML AATNV AAWTL AAYZH ABAKF ABBRH ABCQX ABDBE ABDBF ABFSG ABJNI ABLJU ABOCM ABRTQ ABUWG ABZZP ACAOD ACGFO ACGFS ACKTT ACMJI ACPRK ACRQY ACSTC ACUHS ACZOJ ADBBV ADFRT AEFQL AEJRE AEMSY AENEX AEUYN AEVLU AEXYK AEZWR AFBBN AFDZB AFHIU AFKRA AFRAH AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AHWEU AIGIU AIXLP AJRNO ALFFA ALMA_UNASSIGNED_HOLDINGS AMYLF AN0 APEBS ATCPS ATHPR AXYYD AYFIA AZQEC B0M BBNVY BENPR BHPHI BKEYQ BKKNO BKOMP BNQBC BPHCQ BVXVI CCPQU CS3 DNIVK DPUIP DU5 DWQXO E.L E3Z EAD EAP EAS EBC EBD EBLON EBO EBS ECGQY EE. EHN EIHBH EIOEI EMB EMK EMOBN EPL EPT ESTFP ESX EX3 F5P FDQFY FERAY FIGPU FSGXE FYUFA GNUQQ GUQSH HCIFZ HZ~ IAG IAO ICU IEA IHR IHT IHW INH INR IOF ITC IWAJR JSO JZLTJ K9. KQ8 LGEZI LK8 LOTEE M0K M1P M2O M7P MBDVC NADUK NAPCQ NQJWS NXXTH O9- OK1 P2P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PROAC PSQYO Q2X Q9U Q~Q RNT RNTTT ROL RXW SNX SNYQT SOHCF SOJ SRMVM SV3 SWTZT TAE TAOOD TBHMF TDRGL TH9 TR2 TSG TUS UKHRP WH7 WOW ~02 ~8M ~KM 7X8 PUEGO |
| ID | FETCH-LOGICAL-c396t-a254fae50eb82f9d5ecd12d74d97e2fae3d89abbb6829853fb59858edb1c6d353 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 10 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000637668500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0954-3007 1476-5640 |
| IngestDate | Thu Oct 02 08:47:03 EDT 2025 Mon Oct 06 17:37:27 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c396t-a254fae50eb82f9d5ecd12d74d97e2fae3d89abbb6829853fb59858edb1c6d353 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://www.nature.com/articles/s41430-021-00878-6.pdf |
| PQID | 2591863914 |
| PQPubID | 33883 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_2510250506 proquest_journals_2591863914 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-11-01 |
| PublicationDateYYYYMMDD | 2021-11-01 |
| PublicationDate_xml | – month: 11 year: 2021 text: 2021-11-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London |
| PublicationTitle | European journal of clinical nutrition |
| PublicationYear | 2021 |
| Publisher | Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group |
| SSID | ssj0014772 |
| Score | 2.4115179 |
| Snippet | ObjectiveThe prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA)... The prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation... |
| SourceID | proquest |
| SourceType | Aggregation Database |
| StartPage | 1588 |
| SubjectTerms | Acids Adolescence Adolescents Anemia Clusters Cyanocobalamin Dietary supplements Ferritin Folic acid Girls Hemoglobin Iron Nutrient deficiency Placebos Schools Teenagers Vitamin B Vitamin B12 |
| Title | Impact of daily-supervised administration of a package of iron and folic acid and vitamin B12 on hemoglobin levels among adolescent girls (12–19 years): a cluster randomized control trial |
| URI | https://www.proquest.com/docview/2591863914 https://www.proquest.com/docview/2510250506 |
| Volume | 75 |
| WOSCitedRecordID | wos000637668500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NbtQwELZoy4ELPy2ILWU1SAjBwWqcX5sLaksrELCsKqj2VjmxDVF3k7LJVlpOvAPPw8vwJMwYbyuExIWLI9uTxJLtmfF45hvGHmtTVgXKKa5snnJkeA75YIlnnlwJayhNpfeqPHlbjEZyMlHjYHDrglvliid6Rm3aimzku6imC4niVKQvzr9wyhpFt6shhcYa2yCUhMS77o0vbxHSwidvQi2CrP9REYJmokTudikqChEnBwVCZZM8_4sZewlzdOt_x3ab3Qy6Jez9Xgx32DXbbLKtvQbP1bMlPAHv7enN6Jts8LK2PbYFXNApjFaw_Fvsx2sfOgmtA6Pr6ZJ3i3NiKZ01oP8A2yUSDUh8hmyJKhQ0B7ox4AhvGHRVG1-9qHuNL8K-iAEpPttZS1Ak2DIlr6UOfNIjuMKXgk_1HJufivjnt-9CwRJ3ZPfsOf6tmi4I3AFQyJp2Vn_FQQV_e_ApSO6yj0eHHw5e8ZDmgVeJynuu8YzqtM0iW8rYKZPZyojYFKlRhY2xJzFS6bIscxkr1C5cmeFDWlOKKjdJltxj603b2PsMMvL5sBSWFOnUukxbVJ-cNJlOTO5EOmA7qwk8DXu1O72avQF7dNmNu4yuTnRj2wXRCK8sRvn2vz_xgN2IaVH5aMUdtt7PF_Yhu15d9HU3H7K14viEyknhS4mlPBBDtrF_OBofY-1d9IbK-P3QL-VfUoD4eQ |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NbtQwELaqggQXfloQWwoMEiA4WI29-TMSQoVSddVlhVCpets6sQ1Rd5OyyRYtJ96B9-ANeBmehBk3aYWQuPXAKYrt_DmTb8aZn4-xR9pkeYJ6iisbhxwBzyEOZrjmiZWwhmgqfVTl_jAZjdKDA_Vuif3ocmEorLLDRA_UpsrpH_kGmukiRXUqwpfHnzmxRpF3taPQOBWLXbv4gku2-sVgC9_vYym33-y93uEtqwDP-ypuuMYlkdM2CmyWSqdMZHMjpElCoxIrsadvUqWzLItTqVCZuSzCTWpNJvLYeJYIhPxL-FiCQsiS9_tnXosw8WRRaLWQtyFI2iSdoJ9u1CEaJgGngAiqApfy-C_w9xpt-_r_Nhc32LXWdobNU2G_yZZsucJWN0vdVNMFPAEfzerdBCust1XYBtvauqcTGHW0A6vs58CnhkLlwOhisuD1_Jggs7YG9B_FhGmIBhx8hLBLO5QUCLo04KieMui8MH73pGg0HgivhAQc8clOKyq1gi0TisqqwZM6wXn9LPhYzLD5qZC_vn0XChY4nfWz53i1fDKn4hWARoSppsVXvKk2nwA8xcot9uFCJvk2Wy6r0t5hEFFMi6W0q0CH1kXaonnoUhPpvomdCHtsvROYcYtF9fhcWnrs4Vk3ogi5hnRpqzmNEd4YDuK1f5_iAbuys_d2OB4ORrt32VVJAu0zM9fZcjOb23vscn7SFPXsvv80gB1etPz9BgSCUWU |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1ba9RAFB5KFfGlaqu4teoRVPRh2EzuI4jUrotLy9IHlb6tk8yMDd1N6ibbsn3yP_hvBP-Mv8RzpkmLCL71wacwl1yYnHznTM7lY-yp0lmeoJ7i0sQhR8CziIMZ7nliKYwmmkoXVflpLxmP04MDub_CfnS5MBRW2WGiA2pd5fSPvI9mukhRnYqwb9uwiP3B8M3xV04MUuRp7eg0zkVk1yxPcftWvx4N8F0_8_3huw8773nLMMDzQMYNV7g9sspEnslS30odmVwLXyehlonxcSTQqVRZlsWpL1Gx2SzCQ2p0JvJYO8YIhP9rSYBSTFnqOxfhJSJMHHEUWjDkefCSNmHHC9J-HaKR4nEKjqCKcCmP_1IETrsNb_3P63KbrbU2NWyffwR32Iop19nGdqmaaraE5-CiXJ37YJ31BoVpsK-thzqFcUdHsMF-jlzKKFQWtCqmS14vjglKa6NB_VFkmKYowMlHCMfUoGRBUKUGS3WWQeWFds2TolF4IrwVPuCMQzOrqAQL9kwpWqsGR_YEl3W14Esxx-4Xwv_17buQsMTlrF--wrvl0wUVtQA0LnQ1K87wodo8A3DUK3fZxytZ5HtstaxKc59BRLEuhtKxPBUaGymDZqNNdaQCHVsR9thWJzyTFqPqyaXk9NiTi2FEF3IZqdJUC5ojnJHsxZv_vsRjdgPFbrI3Gu8-YDd9km2XsLnFVpv5wjxk1_OTpqjnj9xXAuzzVYvfb3X5WcA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Impact+of+daily-supervised+administration+of+a+package+of+iron+and+folic+acid+and+vitamin+B12+on+hemoglobin+levels+among+adolescent+girls+%2812%E2%80%9319+years%29%3A+a+cluster+randomized+control+trial&rft.jtitle=European+journal+of+clinical+nutrition&rft.au=Gupta+Aakriti&rft.au=Kant+Shashi&rft.au=Ramakrishnan+Lakshmy&rft.au=Pandey%2C+Ravindra+Mohan&rft.date=2021-11-01&rft.pub=Nature+Publishing+Group&rft.issn=0954-3007&rft.eissn=1476-5640&rft.volume=75&rft.issue=11&rft.spage=1588&rft.epage=1597&rft_id=info:doi/10.1038%2Fs41430-021-00878-6&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0954-3007&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0954-3007&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0954-3007&client=summon |