Impact of daily-supervised administration of a package of iron and folic acid and vitamin B12 on hemoglobin levels among adolescent girls (12–19 years): a cluster randomized control trial

ObjectiveThe prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B12 on hemoglobin lev...

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Published in:European journal of clinical nutrition Vol. 75; no. 11; pp. 1588 - 1597
Main Authors: Gupta Aakriti, Kant Shashi, Ramakrishnan Lakshmy, Pandey, Ravindra Mohan, Khandelwal Ritika, Kapil Umesh, Sachdev Harshpal Singh
Format: Journal Article
Language:English
Published: London Nature Publishing Group 01.11.2021
Subjects:
Acids
Adolescence
Adolescents
Anemia
Clusters
Cyanocobalamin
Dietary supplements
Ferritin
Folic acid
Girls
Hemoglobin
Iron
Nutrient deficiency
Placebos
Schools
Teenagers
Vitamin B
Vitamin B12
ISSN:0954-3007, 1476-5640, 1476-5640
Online Access:Get full text
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Summary:ObjectiveThe prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B12 on hemoglobin levels among adolescent girls.MethodsA community-based cluster-randomized trial was conducted in the rural block of Faridabad District, Haryana, India in the year 2017. A total of 760 adolescent girls in the age group of 12–19 years with mild and moderate anemia were selected from government schools. Daily-supervised administration of iron and folic acid was conducted for 90 days: experimental group—IFA (iron (60 mg), folic acid (500) mcg), and cyanocobalamin (1000 mcg), control group—IFA and placebo. Hemoglobin, serum ferritin, and vitamin B12 levels were assessed at baseline and endline.ResultsTwo-hundred adolescent girls completed 90 doses of daily supplementation. The mean hemoglobin (experimental group: 1.3 ± 1.0 g/dL, control group: 1.6 ± 1.2 g/dL, P = 0.004) and ferritin levels (experimental group: 18.6 ± 31.5 ng/mL, control group: 18.8 ± 35.0 ng/mL, P = 0.188) increased in both the control and experiment groups. Serum vitamin B12 deficiency significantly reduced to 2.5% in the experimental group and ferritin deficiency alleviated in more than 96% of the girls post intervention.ConclusionsDaily supplementation of IFA with/without vitamin B12 for 90 days eliminated iron, vitamin B12 deficiency and reduced the overall proportion of anemia by 53.5%. However, addition of vitamin B12 to IFA supplementation had no impact on improving the hemoglobin levels among adolescent girls. The present study does not recommend provision of vitamin B12 for prevention and treatment of anemia in this population group.
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ISSN:0954-3007
1476-5640
1476-5640
DOI:10.1038/s41430-021-00878-6