Subset-Specific Expression of Toll-Like Receptors by Bovine Afferent Lymph Dendritic Cells
Within the ruminant system, several possibilities exist to generate dendritic cells migrating out from the tissue into the regional draining lymph nodes as afferent lymph dendritic cells (ALDCs). Here, we analyzed toll-like receptor (TLR) 1-10 mRNA expression by using quantitative real-time PCR in h...
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| Veröffentlicht in: | Frontiers in veterinary science Jg. 4; S. 44 |
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| Abstract | Within the ruminant system, several possibilities exist to generate dendritic cells migrating out from the tissue into the regional draining lymph nodes as afferent lymph dendritic cells (ALDCs). Here, we analyzed toll-like receptor (TLR) 1-10 mRNA expression by using quantitative real-time PCR in highly purified subsets of bovine ALDC. As TLR expression may be influenced by pathogens or vaccines and their adjuvant, it is necessary to understand what TLRs are expressed in a steady-state system to elucidate specific differences and to potentially optimize targeted vaccines. In this study, we have assessed the TLR expression profiles of the four main bovine ALDC subsets [cDC1 and cDC2 (subsets 2-4)]. We demonstrate differences in TLR expression between the four subsets that may reflect the ability of these cells to respond to different pathogens or to respond to adjuvants. |
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| AbstractList | Within the ruminant system, several possibilities exist to generate dendritic cells migrating out from the tissue into the regional draining lymph nodes as afferent lymph dendritic cells (ALDCs). Here, we analyzed toll-like receptor (TLR) 1-10 mRNA expression by using quantitative real-time PCR in highly purified subsets of bovine ALDC. As TLR expression may be influenced by pathogens or vaccines and their adjuvant, it is necessary to understand what TLRs are expressed in a steady-state system to elucidate specific differences and to potentially optimize targeted vaccines. In this study, we have assessed the TLR expression profiles of the four main bovine ALDC subsets [cDC1 and cDC2 (subsets 2-4)]. We demonstrate differences in TLR expression between the four subsets that may reflect the ability of these cells to respond to different pathogens or to respond to adjuvants. Within the ruminant system, several possibilities exist to generate dendritic cells migrating out from the tissue into the regional draining lymph nodes as afferent lymph dendritic cells (ALDCs). Here, we analyzed toll-like receptor (TLR) 1-10 mRNA expression by using quantitative real-time PCR in highly purified subsets of bovine ALDC. As TLR expression may be influenced by pathogens or vaccines and their adjuvant, it is necessary to understand what TLRs are expressed in a steady-state system to elucidate specific differences and to potentially optimize targeted vaccines. In this study, we have assessed the TLR expression profiles of the four main bovine ALDC subsets [cDC1 and cDC2 (subsets 2-4)]. We demonstrate differences in TLR expression between the four subsets that may reflect the ability of these cells to respond to different pathogens or to respond to adjuvants.Within the ruminant system, several possibilities exist to generate dendritic cells migrating out from the tissue into the regional draining lymph nodes as afferent lymph dendritic cells (ALDCs). Here, we analyzed toll-like receptor (TLR) 1-10 mRNA expression by using quantitative real-time PCR in highly purified subsets of bovine ALDC. As TLR expression may be influenced by pathogens or vaccines and their adjuvant, it is necessary to understand what TLRs are expressed in a steady-state system to elucidate specific differences and to potentially optimize targeted vaccines. In this study, we have assessed the TLR expression profiles of the four main bovine ALDC subsets [cDC1 and cDC2 (subsets 2-4)]. We demonstrate differences in TLR expression between the four subsets that may reflect the ability of these cells to respond to different pathogens or to respond to adjuvants. |
| Author | Werling, Dirk Hope, Jayne C. Siddiqui, Nazneen Russell, Chris Coffey, Tracey J. Widdison, Stephanie Sopp, Paul |
| AuthorAffiliation | 2 Institute for Animal Health , Newbury, Berkshire , UK 1 The Royal Veterinary College , Hatfield, Hertfordshire , UK |
| AuthorAffiliation_xml | – name: 1 The Royal Veterinary College , Hatfield, Hertfordshire , UK – name: 2 Institute for Animal Health , Newbury, Berkshire , UK |
| Author_xml | – sequence: 1 givenname: Dirk surname: Werling fullname: Werling, Dirk – sequence: 2 givenname: Jayne C. surname: Hope fullname: Hope, Jayne C. – sequence: 3 givenname: Nazneen surname: Siddiqui fullname: Siddiqui, Nazneen – sequence: 4 givenname: Stephanie surname: Widdison fullname: Widdison, Stephanie – sequence: 5 givenname: Chris surname: Russell fullname: Russell, Chris – sequence: 6 givenname: Paul surname: Sopp fullname: Sopp, Paul – sequence: 7 givenname: Tracey J. surname: Coffey fullname: Coffey, Tracey J. |
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| CitedBy_id | crossref_primary_10_1016_j_rvsc_2023_03_003 crossref_primary_10_1016_j_ttbdis_2019_101365 crossref_primary_10_3389_fmicb_2018_03007 crossref_primary_10_1111_imr_13050 |
| Cites_doi | 10.1111/j.1365-2052.2005.01364.x 10.1016/j.vetimm.2010.10.014 10.1007/978-3-540-72167-3_1 10.1038/nprot.2006.125 10.4049/jimmunol.147.11.3703 10.4049/jimmunol.1600672 10.1016/j.vetimm.2006.03.007 10.1016/j.tube.2009.09.003 10.1016/0165-2427(93)90161-V 10.4049/jimmunol.1000824 10.4049/jimmunol.159.11.5372 10.1007/978-1-4615-1971-3_22 10.1189/jlb.0912452 10.1016/j.coi.2005.02.007 10.1016/S0165-2427(00)00234-8 10.3389/fimmu.2015.00260 10.1128/JVI.05127-11 10.4049/jimmunol.168.9.4531 10.1186/1297-9716-43-17 10.4049/jimmunol.164.11.5998 10.4049/jimmunol.166.1.249 10.1189/jlb.69.2.271 10.1111/j.1365-3083.1988.tb02381.x 10.1111/j.0019-2805.2004.01820.x 10.1016/j.vaccine.2012.01.036 10.1111/j.1365-2567.2004.01781.x 10.4049/jimmunol.174.5.2942 10.1128/JVI.00264-12 10.1007/978-1-4757-9966-8_31 10.1046/j.1365-2567.2003.01712.x 10.1371/journal.pone.0067277 10.1016/j.vetimm.2011.09.007 10.1002/(SICI)1521-4141(199801)28:011::AID-IMMU13.0.CO;2-V 10.1038/nri1246 10.1016/S0165-2427(02)00043-0 10.1371/journal.pone.0143519 10.1189/jlb.0605288 10.1007/s00281-004-0168-0 10.1128/IAI.71.11.6420-6425.2003 10.1051/vetres/2010006 10.1002/jlb.66.1.50 |
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| Keywords | bovine dendritic cell subsets afferent lymph toll-like receptors dendritic cell |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Scott Napper, University of Saskatchewan, Canada Specialty section: This article was submitted to Veterinary Infectious Diseases, a section of the journal Frontiers in Veterinary Science Reviewed by: Kieran G. Meade, Teagasc – The Irish Agriculture and Food Development Authority, Ireland; Hans-Joachim Schuberth, University of Veterinary Medicine, Germany Present address: Jayne C. Hope, The Roslin Institute & R(D)SVS, University of Edinburgh, Easter Bush, Midlothian, UK; Paul Sopp, The Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK; Tracey J. Coffey, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire, UK |
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| Title | Subset-Specific Expression of Toll-Like Receptors by Bovine Afferent Lymph Dendritic Cells |
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