Clinical, histopathological, and immunological evaluation of a series of patients with erythema nodosum

Background The pathogenesis of erythema nodosum (EN) is still poorly understood, and studies evaluating the involvement of a cytokine network are very scarce. Objectives To investigate clinical and pathological features, the cytokine profiles, and the balance of T‐regulatory (Treg) and T‐helper (Th)...

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Vydané v:International journal of dermatology Ročník 55; číslo 5; s. e289 - e294
Hlavní autori: De Simone, Clara, Caldarola, Giacomo, Scaldaferri, Franco, Petito, Valentina, Perino, Francesca, Arena, Vincenzo, Papini, Manuela, Caproni, Marzia, Peris, Ketty
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Blackwell Publishing Ltd 01.05.2016
Predmet:
Adult
Blood Sedimentation
C-Reactive Protein - metabolism
Chemokine CCL2 - metabolism
Cytokines - blood
Cytokines - metabolism
Erythema Nodosum - immunology
Erythema Nodosum - metabolism
Erythema Nodosum - pathology
Female
Granulocyte Colony-Stimulating Factor - metabolism
Humans
Interleukin-6 - blood
Interleukin-8 - blood
Lymphocyte Count
Male
Neutrophils
T-Lymphocytes, Regulatory
Th17 Cells
Tumor Necrosis Factor-alpha - blood
Young Adult
ISSN:0011-9059, 1365-4632, 1365-4632
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Shrnutí:Background The pathogenesis of erythema nodosum (EN) is still poorly understood, and studies evaluating the involvement of a cytokine network are very scarce. Objectives To investigate clinical and pathological features, the cytokine profiles, and the balance of T‐regulatory (Treg) and T‐helper (Th)17 cells in serum and lesional skin of patients with EN. Methods Patients with a diagnosis of EN were consecutively enrolled, and their clinical and histopathological features were recorded. A panel of cytokines was evaluated in both serum and lesional skin using enzyme‐linked immunosorbent assay. Real‐time polymerase chain reaction was performed to evaluate the Treg/Th17 cell balance. Results Histopathological examination of skin biopsy specimens from all patients (four women and one man) showed classical features of EN. The most widely expressed cytokines were innate immunity cytokines (mainly tumor necrosis factor alpha, interleukin‐8 and ‐6) and growth factors (mainly granulocyte colony‐stimulating factor and monocyte chemoattractant protein‐1). The Treg/Th17 balance was highly different between patients. Conclusions The present study emphasizes the crucial role of neutrophils in the pathogenesis of EN, as high levels of cytokines and growth factors mainly involved in neutrophil recruitment and activation were detected.
Bibliografia:istex:93FF974CE10F20C718B3BE6C75D259EDD79A9547
ArticleID:IJD13212
ark:/67375/WNG-2S2K7JRC-J
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0011-9059
1365-4632
1365-4632
DOI:10.1111/ijd.13212