Is Reduction of Pocket Probing Depth Correlated with the Baseline Value or is it "Mathematical Coupling"?

Previous studies using correlation or regression analysis have showed that treatment effects measured by the change in clinical parameters are often associated with baseline values of the same parameters. These studies, however, have a methodological weakness. Correlation/regression between baseline...

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Vydáno v:Journal of dental research Ročník 81; číslo 10; s. 722 - 726
Hlavní autoři: Tu, Y.-K., Gilthorpe, M.S., Griffiths, G.S.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States SAGE Publications 01.10.2002
SAGE PUBLICATIONS, INC
Témata:
Algorithms
correlation coefficient
Humans
Likelihood Functions
Models, Statistical
Periodontal Pocket - therapy
periodontal research
Probability
Regression Analysis
regression coefficient
regression to the mean
Research Design - statistics & numerical data
Statistics, Nonparametric
regression coefficient
correlation coefficient
regression to the mean
periodontal research
ISSN:0022-0345, 1544-0591
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Shrnutí:Previous studies using correlation or regression analysis have showed that treatment effects measured by the change in clinical parameters are often associated with baseline values of the same parameters. These studies, however, have a methodological weakness. Correlation/regression between baseline measures and the derived change variable invalidates the statistical procedures of testing the null hypothesis: that the coefficient of correlation/regression is zero. This is due to the phenomenon of mathematical coupling. To investigate the impact that this has on the observed correlation/regression coefficient when in reality this is zero, we used random simulations of hypothetical data to model the treatment of periodontal pockets. Results showed a strong probability of obtaining statistically significant correlation/regression coefficients. To separate this artificial effect of mathematical coupling from the true underlying biological relationship, one must apply appropriate analytical strategies to re-evaluate previous evidence within the periodontal literature.
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ISSN:0022-0345
1544-0591
DOI:10.1177/154405910208101013