3-D X-Ray-Induced Acoustic Computed Tomography With a Spherical Array: A Simulation Study on Bone Imaging

X-ray-induced acoustic computed tomography (XACT) is a promising imaging modality combining high X-ray absorption contrast with the 3-D propagation advantages provided by high-resolution ultrasound waves. The purpose of this study was to optimize the configuration of a 3-D XACT imaging system for bo...

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Bibliographic Details
Published in:IEEE transactions on ultrasonics, ferroelectrics, and frequency control Vol. 67; no. 8; pp. 1613 - 1619
Main Authors: Li, Yang, Samant, Pratik, Wang, Siqi, Behrooz, A., Li, Dengwang, Xiang, Liangzhong
Format: Journal Article
Language:English
Published: United States IEEE 01.08.2020
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:
3-D ultrasound array
3-D volumetric imaging
Absorptivity
Acoustics
Biological properties
bone density map
Bones
Coefficient of variation
Computed tomography
Computer simulation
Configurations
Digital imaging
High resolution
Image reconstruction
Image resolution
Iterative algorithms
Iterative methods
Mathematical analysis
Medical imaging
Peak frequency
Spatial resolution
Three-dimensional displays
Tomography
Ultrasonic testing
Wave propagation
X ray absorption
X ray imagery
X-ray imaging
X-ray-induced acoustic computed tomography (XACT)
ISSN:0885-3010, 1525-8955, 1525-8955
Online Access:Get full text
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Summary:X-ray-induced acoustic computed tomography (XACT) is a promising imaging modality combining high X-ray absorption contrast with the 3-D propagation advantages provided by high-resolution ultrasound waves. The purpose of this study was to optimize the configuration of a 3-D XACT imaging system for bone imaging. A 280 ultrasonic sensors with peak frequency of 10 MHz was designed to distribute on a spherical surface to optimize the 3-D volumetric imaging capability. We performed both theoretical calculations and simulations of this optimized XACT imaging configuration on a mouse-sized digital phantom containing various X-ray absorption coefficients. Iteration algorithm based on total variation has been used for 3-D XACT image reconstruction. The spatial resolution of imaging was estimated to about <inline-formula> <tex-math notation="LaTeX">130~\mu \text{m} </tex-math></inline-formula> along both axial and lateral directions. We simulate XACT imaging of bone microstructures using digital phantoms generated from micro-CT images of real biological samples, showing that XACT imaging can provide high-resolution imaging of the mouse paw. Results of this study will greatly enhance the potential of XACT imaging in the evaluation of bone diseases for future clinical use.
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ISSN:0885-3010
1525-8955
1525-8955
DOI:10.1109/TUFFC.2020.2983732