Combinatorial anticancer effects of curcumin and 5-fluorouracil loaded thiolated chitosan nanoparticles towards colon cancer treatment

Evaluation of the combinatorial anticancer effects of curcumin/5-fluorouracil loaded thiolated chitosan nanoparticles (CRC-TCS-NPs/5-FU-TCS-NPs) on colon cancer cells and the analysis of pharmacokinetics and biodistribution of CRC-TCS-NPs/5-FU-TCS-NPs in a mouse model. CRC-TCS-NPs/5-FU-TCS-NPs were...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1840; no. 9; pp. 2730 - 2743
Main Authors:	Anitha, A., Deepa, N., Chennazhi, K.P., Lakshmanan, Vinoth-Kumar, Jayakumar, R.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.09.2014
Subjects:	5-Fluorouracil Animals antineoplastic activity bioavailability Biological Availability blood cell cycle Cell Cycle - drug effects Cell Line, Tumor chitosan Chitosan - pharmacokinetics Chitosan - pharmacology Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology colorectal neoplasms Combinatorial nanomedicine crosslinking Curcumin Curcumin - pharmacokinetics Curcumin - pharmacology Delayed-Action Preparations - pharmacokinetics Delayed-Action Preparations - pharmacology drug therapy fluorouracil Fluorouracil - pharmacokinetics Fluorouracil - pharmacology Humans membrane potential Membrane Potential, Mitochondrial - drug effects Mice mitochondrial membrane nanomedicine Nanoparticles neoplasm cells patient compliance Pharmacokinetics Thiolated chitosan zeta potential DDA H and E PT RNA COX-2 5-Fluorouracil TCS EPR CO2 FT-IR DLS Mw MTT AUC RPM I BSA PPP FdUMP Colon cancer TPP OD FBS pH IEC 6 Thiolated chitosan Hb Curcumin HPLC Rh 123 RNase PBS aPTT ACD 5-FU-TCS-NPs CRC-TCS-NPs FUTP EDTA NPs HT29 CRC DNA PI SEM FdUTP Pharmacokinetics 5-FU JC-1 Combinatorial nanomedicine
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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