Steatosis and NASH in type 2 diabetes

Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given t...

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Vydáno v:	Biochimie Ročník 143; s. 37 - 41
Hlavní autoři:	Hu, Mengyue, Phan, Franck, Bourron, Olivier, Ferré, Pascal, Foufelle, Fabienne
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	France Elsevier B.V 01.12.2017
Témata:	Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology dissociation fatty acids fatty liver fibrosis Hepatitis - etiology Humans Inflammation Insulin Resistance Lipotoxicity NASH Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism noninsulin-dependent diabetes mellitus oxidative stress Risk Factors Steatosis Type 2 diabetes Type 2 diabetes Insulin resistance Inflammation NASH Lipotoxicity Steatosis
ISSN:	0300-9084, 1638-6183, 1638-6183
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Abstract	Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets. •Steatosis and NASH are frequent among type 2 diabetic individuals.•In NAFLD patients, an increased dose of injected insulin is often necessary.•Insulin resistance promotes NAFLD through induced hepatic lipogenesis and adipose tissue lipolysis.•NAFLD enhances insulin resistance by inducing lipotoxicity, inflammation and ROS production.•Specific intrahepatic lipid species are important for alteration of insulin sensitivity.
AbstractList	Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets.Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets. Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets. •Steatosis and NASH are frequent among type 2 diabetic individuals.•In NAFLD patients, an increased dose of injected insulin is often necessary.•Insulin resistance promotes NAFLD through induced hepatic lipogenesis and adipose tissue lipolysis.•NAFLD enhances insulin resistance by inducing lipotoxicity, inflammation and ROS production.•Specific intrahepatic lipid species are important for alteration of insulin sensitivity. Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets.
Author	Phan, Franck Ferré, Pascal Foufelle, Fabienne Hu, Mengyue Bourron, Olivier
Author_xml	– sequence: 1 givenname: Mengyue surname: Hu fullname: Hu, Mengyue organization: INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France – sequence: 2 givenname: Franck orcidid: 0000-0002-1412-9687 surname: Phan fullname: Phan, Franck organization: INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France – sequence: 3 givenname: Olivier surname: Bourron fullname: Bourron, Olivier organization: INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France – sequence: 4 givenname: Pascal surname: Ferré fullname: Ferré, Pascal organization: INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France – sequence: 5 givenname: Fabienne surname: Foufelle fullname: Foufelle, Fabienne email: fabienne.foufelle@crc.jussieu.fr organization: INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France
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Cites_doi	10.1002/hep.1840120505 10.1053/j.gastro.2013.11.049 10.1111/j.1478-3231.2011.02482.x 10.1055/s-0028-1091981 10.1172/JCI200422422 10.1053/jhep.2001.29628 10.1053/j.gastro.2011.06.061 10.1016/j.jhep.2016.01.002 10.1038/nm0410-400 10.1111/j.1463-1326.2010.01275.x 10.1016/j.cmet.2007.05.005 10.1016/j.jhep.2012.02.028 10.1038/nrendo.2016.124 10.1056/NEJMra0912063 10.1074/jbc.M301977200 10.1002/hep.510300604 10.1038/nm1166 10.1074/jbc.M410310200 10.1111/j.1464-5491.2005.01582.x 10.1172/JCI8814 10.2337/dc07-1463 10.1038/nm1185 10.1111/j.1572-0241.2004.40009.x 10.1111/jgh.13026 10.2337/diab.38.12.1595 10.1002/hep.21655 10.1194/jlr.M010256 10.1186/1476-511X-9-42 10.1002/hep.21327 10.1146/annurev-physiol-021909-135846 10.1111/j.1478-3231.2005.01191.x 10.1155/2013/450639 10.1016/S0016-5085(98)70599-2 10.1016/j.jhep.2003.09.020 10.3109/07853890.2010.518623 10.1016/S0002-9343(99)00271-5 10.1016/j.cmet.2012.03.004 10.1111/jdi.12560 10.1016/S1043-2760(00)00272-1 10.1210/jc.2010-2190 10.1002/hep.21763 10.1002/hep.510270121
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Keywords	Type 2 diabetes Insulin resistance Inflammation NASH Lipotoxicity Steatosis
Language	English
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References	Ferré, Foufelle (bib13) 2010 Oct 1; 12 Browning, Horton (bib14) 2004 Jul 15; 114 Leroux, Ferrere, Godie, Cailleux, Renoud, Gaudin (bib22) 2012 Jul 1; 57 Charlton, Burns, Pedersen, Watt, Heimbach, Dierkhising (bib5) 2011 Oct; 141 Carbone, Angus, Yeomans (bib19) 2016 Jan 1; 31 Erion, Shulman (bib34) 2010 Apr; 16 Leite, Villela-Nogueira, Pannain, Bottino, Rezende, Cardoso (bib7) 2011 May; 31 Abiru, Migita, Maeda, Daikoku, Ito, Ohata (bib25) 2006 Feb 1; 26 White, Kanwal, El-Serag (bib3) 2012 Dec; 10 Targher, Day, Bonora (bib4) 2010 Sep 30; 363 Liu, Bengmark, Qu (bib11) 2010; 9 Puri, Baillie, Wiest, Mirshahi, Choudhury, Cheung (bib33) 2007 Oct 1; 46 Crespo, Cayón, Fernández-Gil, Hernández-Guerra, Mayorga, Domínguez-Díez (bib26) 2001 Dec 1; 34 Farese, Zechner, Newgard, Walther (bib46) 2012 May 2; 15 Olefsky, Glass (bib24) 2010; 72 Brown, Betters, Lord, Ma, Han, Yang (bib45) 2010 Nov 1; 51 Rinella, Green (bib43) 2004 Jan 1; 40 Angulo, Keach, Batts, Lindor (bib8) 1999 Dec; 30 Jensen, Caruso, Heiling, Miles (bib12) 1989 Dec 1; 38 Rotter, Nagaev, Smith (bib39) 2003 Nov 14; 278 Ribeiro, Cortez-Pinto, Solá, Castro, Ramalho, Baptista (bib37) 2004 Sep; 99 Mavrogiannaki, Migdalis (bib1) 2013; 2013 Xue, Lv, Chen, Liang, Zhao, Zhang (bib31) 2017 Mar; 8 Moller (bib38) 2000 Aug 1; 11 Hossain, Afendy, Stepanova, Nader, Srishord, Rafiq (bib9) 2009 Nov; 7 Sung, Kim (bib27) 2011 Apr 1; 96 Day, James (bib20) 1998 Apr; 114 Weltman, Farrell, Hall, Ingelman-Sundberg, Liddle (bib41) 1998 Jan; 27 Ekstedt, Franzén, Mathiesen, Thorelius, Holmqvist, Bodemar (bib2) 2006 Oct; 44 Jimba, Nakagami, Takahashi, Wakamatsu, Hirota, Iwamoto (bib29) 2005 Sep 1; 22 Luukkonen, Zhou, Sädevirta, Leivonen, Arola, Orešič (bib32) 2016 May; 64 Cai, Yuan, Frantz, Melendez, Hansen, Lee (bib36) 2005 Feb; 11 Leclercq, Farrell, Field, Bell, Gonzalez, Robertson (bib40) 2000 Apr 15; 105 Musso, Gambino, Cassader, Pagano (bib28) 2011 Dec 1; 43 Marchesini, Brizi, Morselli-Labate, Bianchi, Bugianesi, McCullough (bib18) 1999 Nov 1; 107 Wanless, Lentz (bib6) 1990 Nov; 12 Lambert, Ramos–Roman, Browning, Parks (bib15) 2014 Mar 1; 146 Schattenberg, Wang, Singh, Rigoli, Czaja (bib42) 2005 Mar 18; 280 Sung, Kim (bib10) 2011 Apr; 96 Yamaguchi, Yang, McCall, Huang, Yu, Pandey (bib21) 2007 Jun 1; 45 Baiceanu, Mesdom, Lagouge, Foufelle (bib16) 2016 Dec; 12 Jou, Choi, Diehl (bib23) 2008 Nov; 28 Monetti, Levin, Watt, Sajan, Marmor, Hubbard (bib44) 2007 Jul; 6 Arkan, Hevener, Greten, Maeda, Li, Long (bib35) 2005 Feb; 11 Kotronen, Juurinen, Hakkarainen, Westerbacka, Cornér, Bergholm (bib17) 2008 Jan 1; 31 Ekstedt, Franzén, Mathiesen, Thorelius, Holmqvist, Bodemar (bib30) 2006 Oct 1; 44 Leite (10.1016/j.biochi.2017.10.019_bib7) 2011; 31 Crespo (10.1016/j.biochi.2017.10.019_bib26) 2001; 34 Cai (10.1016/j.biochi.2017.10.019_bib36) 2005; 11 Wanless (10.1016/j.biochi.2017.10.019_bib6) 1990; 12 Olefsky (10.1016/j.biochi.2017.10.019_bib24) 2010; 72 Ribeiro (10.1016/j.biochi.2017.10.019_bib37) 2004; 99 Moller (10.1016/j.biochi.2017.10.019_bib38) 2000; 11 Ekstedt (10.1016/j.biochi.2017.10.019_bib30) 2006; 44 Monetti (10.1016/j.biochi.2017.10.019_bib44) 2007; 6 Targher (10.1016/j.biochi.2017.10.019_bib4) 2010; 363 Marchesini (10.1016/j.biochi.2017.10.019_bib18) 1999; 107 Brown (10.1016/j.biochi.2017.10.019_bib45) 2010; 51 Ekstedt (10.1016/j.biochi.2017.10.019_bib2) 2006; 44 Ferré (10.1016/j.biochi.2017.10.019_bib13) 2010; 12 Schattenberg (10.1016/j.biochi.2017.10.019_bib42) 2005; 280 Baiceanu (10.1016/j.biochi.2017.10.019_bib16) 2016; 12 Abiru (10.1016/j.biochi.2017.10.019_bib25) 2006; 26 Luukkonen (10.1016/j.biochi.2017.10.019_bib32) 2016; 64 Arkan (10.1016/j.biochi.2017.10.019_bib35) 2005; 11 Farese (10.1016/j.biochi.2017.10.019_bib46) 2012; 15 Day (10.1016/j.biochi.2017.10.019_bib20) 1998; 114 Charlton (10.1016/j.biochi.2017.10.019_bib5) 2011; 141 Musso (10.1016/j.biochi.2017.10.019_bib28) 2011; 43 Kotronen (10.1016/j.biochi.2017.10.019_bib17) 2008; 31 Xue (10.1016/j.biochi.2017.10.019_bib31) 2017; 8 Mavrogiannaki (10.1016/j.biochi.2017.10.019_bib1) 2013; 2013 Sung (10.1016/j.biochi.2017.10.019_bib27) 2011; 96 Leroux (10.1016/j.biochi.2017.10.019_bib22) 2012; 57 Browning (10.1016/j.biochi.2017.10.019_bib14) 2004; 114 Yamaguchi (10.1016/j.biochi.2017.10.019_bib21) 2007; 45 Sung (10.1016/j.biochi.2017.10.019_bib10) 2011; 96 Jou (10.1016/j.biochi.2017.10.019_bib23) 2008; 28 Puri (10.1016/j.biochi.2017.10.019_bib33) 2007; 46 White (10.1016/j.biochi.2017.10.019_bib3) 2012; 10 Angulo (10.1016/j.biochi.2017.10.019_bib8) 1999; 30 Jensen (10.1016/j.biochi.2017.10.019_bib12) 1989; 38 Hossain (10.1016/j.biochi.2017.10.019_bib9) 2009; 7 Liu (10.1016/j.biochi.2017.10.019_bib11) 2010; 9 Carbone (10.1016/j.biochi.2017.10.019_bib19) 2016; 31 Leclercq (10.1016/j.biochi.2017.10.019_bib40) 2000; 105 Erion (10.1016/j.biochi.2017.10.019_bib34) 2010; 16 Rotter (10.1016/j.biochi.2017.10.019_bib39) 2003; 278 Lambert (10.1016/j.biochi.2017.10.019_bib15) 2014; 146 Weltman (10.1016/j.biochi.2017.10.019_bib41) 1998; 27 Rinella (10.1016/j.biochi.2017.10.019_bib43) 2004; 40 Jimba (10.1016/j.biochi.2017.10.019_bib29) 2005; 22
References_xml	– volume: 8 start-page: 181 year: 2017 Mar end-page: 187 ident: bib31 article-title: Donor liver steatosis: a risk factor for early new-onset diabetes after liver transplantation publication-title: J. Diabetes Investig. – volume: 46 start-page: 1081 year: 2007 Oct 1 end-page: 1090 ident: bib33 article-title: A lipidomic analysis of nonalcoholic fatty liver disease publication-title: Hepatology – volume: 11 start-page: 212 year: 2000 Aug 1 end-page: 217 ident: bib38 article-title: Potential role of TNF-α in the pathogenesis of insulin resistance and type 2 diabetes publication-title: Trends Endocrinol. Metab. – volume: 10 start-page: 1342 year: 2012 Dec end-page: 1359 ident: bib3 article-title: Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review publication-title: Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc. – volume: 12 start-page: 1106 year: 1990 Nov end-page: 1110 ident: bib6 article-title: Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors publication-title: Hepatol. Balt. Md. – volume: 7 start-page: 1224 year: 2009 Nov end-page: 1229 ident: bib9 article-title: Independent predictors of fibrosis in patients with nonalcoholic fatty liver disease publication-title: Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc. – volume: 34 start-page: 1158 year: 2001 Dec 1 end-page: 1163 ident: bib26 article-title: Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients publication-title: Hepatology – volume: 44 start-page: 865 year: 2006 Oct 1 end-page: 873 ident: bib30 article-title: Long-term follow-up of patients with NAFLD and elevated liver enzymes publication-title: Hepatology – volume: 114 start-page: 147 year: 2004 Jul 15 end-page: 152 ident: bib14 article-title: Molecular mediators of hepatic steatosis and liver injury publication-title: J. Clin. Investig. – volume: 40 start-page: 47 year: 2004 Jan 1 end-page: 51 ident: bib43 article-title: The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance publication-title: J. Hepatol. – volume: 9 start-page: 42 year: 2010 ident: bib11 article-title: The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD) publication-title: Lipids Health Dis. – volume: 64 start-page: 1167 year: 2016 May end-page: 1175 ident: bib32 article-title: Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease publication-title: J. Hepatol. – volume: 2013 start-page: 450639 year: 2013 ident: bib1 article-title: Nonalcoholic Fatty liver disease, diabetes mellitus and cardiovascular disease: newer data publication-title: Int. J. Endocrinol. – volume: 31 start-page: 23 year: 2016 Jan 1 end-page: 31 ident: bib19 article-title: Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis publication-title: J. Gastroenterol. Hepatol. – volume: 16 start-page: 400 year: 2010 Apr end-page: 402 ident: bib34 article-title: Diacylglycerol-mediated insulin resistance publication-title: Nat. Med. – volume: 114 start-page: 842 year: 1998 Apr end-page: 845 ident: bib20 article-title: Steatohepatitis: a tale of two “hits”? publication-title: Gastroenterology – volume: 27 start-page: 128 year: 1998 Jan end-page: 133 ident: bib41 article-title: Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis publication-title: Hepatol. Balt. Md – volume: 51 start-page: 3306 year: 2010 Nov 1 end-page: 3315 ident: bib45 article-title: CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance publication-title: J. Lipid Res. – volume: 44 start-page: 865 year: 2006 Oct end-page: 873 ident: bib2 article-title: Long-term follow-up of patients with NAFLD and elevated liver enzymes publication-title: Hepatol. Balt. Md. – volume: 31 start-page: 700 year: 2011 May end-page: 706 ident: bib7 article-title: Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors publication-title: Liver Int. Off. J. Int. Assoc. Study Liver – volume: 146 start-page: 726 year: 2014 Mar 1 end-page: 735 ident: bib15 article-title: Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease publication-title: Gastroenterology – volume: 96 start-page: 1093 year: 2011 Apr 1 end-page: 1097 ident: bib27 article-title: Interrelationship between fatty liver and insulin resistance in the development of type 2 diabetes publication-title: J. Clin. Endocrinol. Metab. – volume: 96 start-page: 1093 year: 2011 Apr end-page: 1097 ident: bib10 article-title: Interrelationship between fatty liver and insulin resistance in the development of type 2 diabetes publication-title: J. Clin. Endocrinol. Metab. – volume: 11 start-page: 191 year: 2005 Feb end-page: 198 ident: bib35 article-title: IKK-β links inflammation to obesity-induced insulin resistance publication-title: Nat. Med. – volume: 15 start-page: 570 year: 2012 May 2 end-page: 573 ident: bib46 article-title: The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance publication-title: Cell Metab. – volume: 38 start-page: 1595 year: 1989 Dec 1 end-page: 1601 ident: bib12 article-title: Insulin regulation of lipolysis in nondiabetic and IDDM subjects publication-title: Diabetes – volume: 12 start-page: 83 year: 2010 Oct 1 end-page: 92 ident: bib13 article-title: Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c publication-title: Diabetes Obes. Metab. – volume: 107 start-page: 450 year: 1999 Nov 1 end-page: 455 ident: bib18 article-title: Association of nonalcoholic fatty liver disease with insulin resistance publication-title: Am. J. Med. – volume: 28 start-page: 370 year: 2008 Nov end-page: 379 ident: bib23 article-title: Mechanisms of disease progression in nonalcoholic fatty liver disease publication-title: Semin. Liver Dis. – volume: 141 start-page: 1249 year: 2011 Oct end-page: 1253 ident: bib5 article-title: Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States publication-title: Gastroenterology – volume: 45 start-page: 1366 year: 2007 Jun 1 end-page: 1374 ident: bib21 article-title: Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis publication-title: Hepatology – volume: 280 start-page: 9887 year: 2005 Mar 18 end-page: 9894 ident: bib42 article-title: Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling publication-title: J. Biol. Chem. – volume: 30 start-page: 1356 year: 1999 Dec end-page: 1362 ident: bib8 article-title: Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis publication-title: Hepatol. Balt. Md. – volume: 105 start-page: 1067 year: 2000 Apr 15 end-page: 1075 ident: bib40 article-title: CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis publication-title: J. Clin. Investig. – volume: 6 start-page: 69 year: 2007 Jul end-page: 78 ident: bib44 article-title: Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver publication-title: Cell Metab. – volume: 31 start-page: 165 year: 2008 Jan 1 end-page: 169 ident: bib17 article-title: Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects publication-title: Diabetes Care – volume: 363 start-page: 1341 year: 2010 Sep 30 end-page: 1350 ident: bib4 article-title: Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease publication-title: N. Engl. J. Med. – volume: 11 start-page: 183 year: 2005 Feb end-page: 190 ident: bib36 article-title: Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB publication-title: Nat. Med. – volume: 57 start-page: 141 year: 2012 Jul 1 end-page: 149 ident: bib22 article-title: Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis publication-title: J. Hepatol. – volume: 43 start-page: 617 year: 2011 Dec 1 end-page: 649 ident: bib28 article-title: Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity publication-title: Ann. Med. – volume: 99 start-page: 1708 year: 2004 Sep end-page: 1717 ident: bib37 article-title: Hepatocyte apoptosis, expression of death receptors, and activation of NF-κB in the liver of nonalcoholic and alcoholic steatohepatitis patients publication-title: Am. J. Gastroenterol. – volume: 278 start-page: 45777 year: 2003 Nov 14 end-page: 45784 ident: bib39 article-title: Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-α, overexpressed in human fat cells from insulin-resistant subjects publication-title: J. Biol. Chem. – volume: 12 start-page: 710 year: 2016 Dec end-page: 722 ident: bib16 article-title: Endoplasmic reticulum proteostasis in hepatic steatosis publication-title: Nat. Rev. Endocrinol. – volume: 22 start-page: 1141 year: 2005 Sep 1 end-page: 1145 ident: bib29 article-title: Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults publication-title: Diabet. Med. – volume: 72 start-page: 219 year: 2010 end-page: 246 ident: bib24 article-title: Macrophages, inflammation, and insulin resistance publication-title: Annu. Rev. Physiol. – volume: 26 start-page: 39 year: 2006 Feb 1 end-page: 45 ident: bib25 article-title: Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis publication-title: Liver Int. – volume: 12 start-page: 1106 issue: 5 year: 1990 ident: 10.1016/j.biochi.2017.10.019_bib6 article-title: Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors publication-title: Hepatol. Balt. Md. doi: 10.1002/hep.1840120505 – volume: 146 start-page: 726 issue: 3 year: 2014 ident: 10.1016/j.biochi.2017.10.019_bib15 article-title: Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease publication-title: Gastroenterology doi: 10.1053/j.gastro.2013.11.049 – volume: 31 start-page: 700 issue: 5 year: 2011 ident: 10.1016/j.biochi.2017.10.019_bib7 article-title: Histopathological stages of nonalcoholic fatty liver disease in type 2 diabetes: prevalences and correlated factors publication-title: Liver Int. Off. J. Int. Assoc. Study Liver doi: 10.1111/j.1478-3231.2011.02482.x – volume: 28 start-page: 370 issue: 04 year: 2008 ident: 10.1016/j.biochi.2017.10.019_bib23 article-title: Mechanisms of disease progression in nonalcoholic fatty liver disease publication-title: Semin. Liver Dis. doi: 10.1055/s-0028-1091981 – volume: 114 start-page: 147 issue: 2 year: 2004 ident: 10.1016/j.biochi.2017.10.019_bib14 article-title: Molecular mediators of hepatic steatosis and liver injury publication-title: J. Clin. Investig. doi: 10.1172/JCI200422422 – volume: 34 start-page: 1158 issue: 6 year: 2001 ident: 10.1016/j.biochi.2017.10.019_bib26 article-title: Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients publication-title: Hepatology doi: 10.1053/jhep.2001.29628 – volume: 141 start-page: 1249 issue: 4 year: 2011 ident: 10.1016/j.biochi.2017.10.019_bib5 article-title: Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States publication-title: Gastroenterology doi: 10.1053/j.gastro.2011.06.061 – volume: 64 start-page: 1167 issue: 5 year: 2016 ident: 10.1016/j.biochi.2017.10.019_bib32 article-title: Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease publication-title: J. Hepatol. doi: 10.1016/j.jhep.2016.01.002 – volume: 16 start-page: 400 issue: 4 year: 2010 ident: 10.1016/j.biochi.2017.10.019_bib34 article-title: Diacylglycerol-mediated insulin resistance publication-title: Nat. Med. doi: 10.1038/nm0410-400 – volume: 12 start-page: 83 year: 2010 ident: 10.1016/j.biochi.2017.10.019_bib13 article-title: Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c publication-title: Diabetes Obes. Metab. doi: 10.1111/j.1463-1326.2010.01275.x – volume: 6 start-page: 69 issue: 1 year: 2007 ident: 10.1016/j.biochi.2017.10.019_bib44 article-title: Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver publication-title: Cell Metab. doi: 10.1016/j.cmet.2007.05.005 – volume: 57 start-page: 141 issue: 1 year: 2012 ident: 10.1016/j.biochi.2017.10.019_bib22 article-title: Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis publication-title: J. Hepatol. doi: 10.1016/j.jhep.2012.02.028 – volume: 12 start-page: 710 issue: 12 year: 2016 ident: 10.1016/j.biochi.2017.10.019_bib16 article-title: Endoplasmic reticulum proteostasis in hepatic steatosis publication-title: Nat. Rev. Endocrinol. doi: 10.1038/nrendo.2016.124 – volume: 363 start-page: 1341 issue: 14 year: 2010 ident: 10.1016/j.biochi.2017.10.019_bib4 article-title: Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0912063 – volume: 278 start-page: 45777 issue: 46 year: 2003 ident: 10.1016/j.biochi.2017.10.019_bib39 article-title: Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-α, overexpressed in human fat cells from insulin-resistant subjects publication-title: J. Biol. Chem. doi: 10.1074/jbc.M301977200 – volume: 30 start-page: 1356 issue: 6 year: 1999 ident: 10.1016/j.biochi.2017.10.019_bib8 article-title: Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis publication-title: Hepatol. Balt. Md. doi: 10.1002/hep.510300604 – volume: 11 start-page: 183 issue: 2 year: 2005 ident: 10.1016/j.biochi.2017.10.019_bib36 article-title: Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB publication-title: Nat. Med. doi: 10.1038/nm1166 – volume: 280 start-page: 9887 issue: 11 year: 2005 ident: 10.1016/j.biochi.2017.10.019_bib42 article-title: Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling publication-title: J. Biol. Chem. doi: 10.1074/jbc.M410310200 – volume: 22 start-page: 1141 issue: 9 year: 2005 ident: 10.1016/j.biochi.2017.10.019_bib29 article-title: Prevalence of non-alcoholic fatty liver disease and its association with impaired glucose metabolism in Japanese adults publication-title: Diabet. Med. doi: 10.1111/j.1464-5491.2005.01582.x – volume: 105 start-page: 1067 issue: 8 year: 2000 ident: 10.1016/j.biochi.2017.10.019_bib40 article-title: CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis publication-title: J. Clin. Investig. doi: 10.1172/JCI8814 – volume: 10 start-page: 1342 issue: 12 year: 2012 ident: 10.1016/j.biochi.2017.10.019_bib3 article-title: Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review publication-title: Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc. – volume: 31 start-page: 165 issue: 1 year: 2008 ident: 10.1016/j.biochi.2017.10.019_bib17 article-title: Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects publication-title: Diabetes Care doi: 10.2337/dc07-1463 – volume: 11 start-page: 191 issue: 2 year: 2005 ident: 10.1016/j.biochi.2017.10.019_bib35 article-title: IKK-β links inflammation to obesity-induced insulin resistance publication-title: Nat. Med. doi: 10.1038/nm1185 – volume: 99 start-page: 1708 issue: 9 year: 2004 ident: 10.1016/j.biochi.2017.10.019_bib37 article-title: Hepatocyte apoptosis, expression of death receptors, and activation of NF-κB in the liver of nonalcoholic and alcoholic steatohepatitis patients publication-title: Am. J. Gastroenterol. doi: 10.1111/j.1572-0241.2004.40009.x – volume: 31 start-page: 23 issue: 1 year: 2016 ident: 10.1016/j.biochi.2017.10.019_bib19 article-title: Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis publication-title: J. Gastroenterol. Hepatol. doi: 10.1111/jgh.13026 – volume: 38 start-page: 1595 issue: 12 year: 1989 ident: 10.1016/j.biochi.2017.10.019_bib12 article-title: Insulin regulation of lipolysis in nondiabetic and IDDM subjects publication-title: Diabetes doi: 10.2337/diab.38.12.1595 – volume: 45 start-page: 1366 issue: 6 year: 2007 ident: 10.1016/j.biochi.2017.10.019_bib21 article-title: Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis publication-title: Hepatology doi: 10.1002/hep.21655 – volume: 51 start-page: 3306 issue: 11 year: 2010 ident: 10.1016/j.biochi.2017.10.019_bib45 article-title: CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance publication-title: J. Lipid Res. doi: 10.1194/jlr.M010256 – volume: 7 start-page: 1224 issue: 11 year: 2009 ident: 10.1016/j.biochi.2017.10.019_bib9 article-title: Independent predictors of fibrosis in patients with nonalcoholic fatty liver disease publication-title: Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc. – volume: 9 start-page: 42 year: 2010 ident: 10.1016/j.biochi.2017.10.019_bib11 article-title: The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD) publication-title: Lipids Health Dis. doi: 10.1186/1476-511X-9-42 – volume: 44 start-page: 865 issue: 4 year: 2006 ident: 10.1016/j.biochi.2017.10.019_bib2 article-title: Long-term follow-up of patients with NAFLD and elevated liver enzymes publication-title: Hepatol. Balt. Md. doi: 10.1002/hep.21327 – volume: 72 start-page: 219 issue: 1 year: 2010 ident: 10.1016/j.biochi.2017.10.019_bib24 article-title: Macrophages, inflammation, and insulin resistance publication-title: Annu. Rev. Physiol. doi: 10.1146/annurev-physiol-021909-135846 – volume: 26 start-page: 39 issue: 1 year: 2006 ident: 10.1016/j.biochi.2017.10.019_bib25 article-title: Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis publication-title: Liver Int. doi: 10.1111/j.1478-3231.2005.01191.x – volume: 2013 start-page: 450639 year: 2013 ident: 10.1016/j.biochi.2017.10.019_bib1 article-title: Nonalcoholic Fatty liver disease, diabetes mellitus and cardiovascular disease: newer data publication-title: Int. J. Endocrinol. doi: 10.1155/2013/450639 – volume: 114 start-page: 842 issue: 4 year: 1998 ident: 10.1016/j.biochi.2017.10.019_bib20 article-title: Steatohepatitis: a tale of two “hits”? publication-title: Gastroenterology doi: 10.1016/S0016-5085(98)70599-2 – volume: 44 start-page: 865 issue: 4 year: 2006 ident: 10.1016/j.biochi.2017.10.019_bib30 article-title: Long-term follow-up of patients with NAFLD and elevated liver enzymes publication-title: Hepatology doi: 10.1002/hep.21327 – volume: 40 start-page: 47 issue: 1 year: 2004 ident: 10.1016/j.biochi.2017.10.019_bib43 article-title: The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance publication-title: J. Hepatol. doi: 10.1016/j.jhep.2003.09.020 – volume: 43 start-page: 617 issue: 8 year: 2011 ident: 10.1016/j.biochi.2017.10.019_bib28 article-title: Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity publication-title: Ann. Med. doi: 10.3109/07853890.2010.518623 – volume: 107 start-page: 450 issue: 5 year: 1999 ident: 10.1016/j.biochi.2017.10.019_bib18 article-title: Association of nonalcoholic fatty liver disease with insulin resistance publication-title: Am. J. Med. doi: 10.1016/S0002-9343(99)00271-5 – volume: 15 start-page: 570 issue: 5 year: 2012 ident: 10.1016/j.biochi.2017.10.019_bib46 article-title: The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance publication-title: Cell Metab. doi: 10.1016/j.cmet.2012.03.004 – volume: 8 start-page: 181 issue: 2 year: 2017 ident: 10.1016/j.biochi.2017.10.019_bib31 article-title: Donor liver steatosis: a risk factor for early new-onset diabetes after liver transplantation publication-title: J. Diabetes Investig. doi: 10.1111/jdi.12560 – volume: 11 start-page: 212 issue: 6 year: 2000 ident: 10.1016/j.biochi.2017.10.019_bib38 article-title: Potential role of TNF-α in the pathogenesis of insulin resistance and type 2 diabetes publication-title: Trends Endocrinol. Metab. doi: 10.1016/S1043-2760(00)00272-1 – volume: 96 start-page: 1093 issue: 4 year: 2011 ident: 10.1016/j.biochi.2017.10.019_bib10 article-title: Interrelationship between fatty liver and insulin resistance in the development of type 2 diabetes publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2010-2190 – volume: 96 start-page: 1093 issue: 4 year: 2011 ident: 10.1016/j.biochi.2017.10.019_bib27 article-title: Interrelationship between fatty liver and insulin resistance in the development of type 2 diabetes publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2010-2190 – volume: 46 start-page: 1081 issue: 4 year: 2007 ident: 10.1016/j.biochi.2017.10.019_bib33 article-title: A lipidomic analysis of nonalcoholic fatty liver disease publication-title: Hepatology doi: 10.1002/hep.21763 – volume: 27 start-page: 128 issue: 1 year: 1998 ident: 10.1016/j.biochi.2017.10.019_bib41 article-title: Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis publication-title: Hepatol. Balt. Md doi: 10.1002/hep.510270121
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Snippet	Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple...
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SubjectTerms	Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology dissociation fatty acids fatty liver fibrosis Hepatitis - etiology Humans Inflammation Insulin Resistance Lipotoxicity NASH Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism noninsulin-dependent diabetes mellitus oxidative stress Risk Factors Steatosis Type 2 diabetes
Title	Steatosis and NASH in type 2 diabetes
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