Steatosis and NASH in type 2 diabetes

Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given t...

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Vydáno v:	Biochimie Ročník 143; s. 37 - 41
Hlavní autoři:	Hu, Mengyue, Phan, Franck, Bourron, Olivier, Ferré, Pascal, Foufelle, Fabienne
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	France Elsevier B.V 01.12.2017
Témata:	Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology dissociation fatty acids fatty liver fibrosis Hepatitis - etiology Humans Inflammation Insulin Resistance Lipotoxicity NASH Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism noninsulin-dependent diabetes mellitus oxidative stress Risk Factors Steatosis Type 2 diabetes Type 2 diabetes Insulin resistance Inflammation NASH Lipotoxicity Steatosis
ISSN:	0300-9084, 1638-6183, 1638-6183
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Abstract	Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets. •Steatosis and NASH are frequent among type 2 diabetic individuals.•In NAFLD patients, an increased dose of injected insulin is often necessary.•Insulin resistance promotes NAFLD through induced hepatic lipogenesis and adipose tissue lipolysis.•NAFLD enhances insulin resistance by inducing lipotoxicity, inflammation and ROS production.•Specific intrahepatic lipid species are important for alteration of insulin sensitivity.
AbstractList	Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets.Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets. Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets. •Steatosis and NASH are frequent among type 2 diabetic individuals.•In NAFLD patients, an increased dose of injected insulin is often necessary.•Insulin resistance promotes NAFLD through induced hepatic lipogenesis and adipose tissue lipolysis.•NAFLD enhances insulin resistance by inducing lipotoxicity, inflammation and ROS production.•Specific intrahepatic lipid species are important for alteration of insulin sensitivity. Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple steatosis, steatohepatitis, to fibrosis and cirrhosis. The association between NAFLD and Type 2 Diabetes (T2D) is strong and complex, given that the prevalence of NAFLD is particularly high in individuals with Type 2 Diabetes. In fact, insulin resistance occurring in this metabolic disease can promote NAFLD development, and vice versa, NAFLD can enhance insulin resistance. In this review, we focus on the mechanisms linking NAFLD and T2D, including fatty acid accumulation, inflammation, oxidative stress etc. We also discuss about situations showing a dissociation between steatosis and insulin resistance, in order to provide new insights for NAFLD therapeutic targets.
Author	Phan, Franck Ferré, Pascal Foufelle, Fabienne Hu, Mengyue Bourron, Olivier
Author_xml	– sequence: 1 givenname: Mengyue surname: Hu fullname: Hu, Mengyue organization: INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France – sequence: 2 givenname: Franck orcidid: 0000-0002-1412-9687 surname: Phan fullname: Phan, Franck organization: INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France – sequence: 3 givenname: Olivier surname: Bourron fullname: Bourron, Olivier organization: INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France – sequence: 4 givenname: Pascal surname: Ferré fullname: Ferré, Pascal organization: INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France – sequence: 5 givenname: Fabienne surname: Foufelle fullname: Foufelle, Fabienne email: fabienne.foufelle@crc.jussieu.fr organization: INSERM UMRS 1138, Sorbonne Université, Centre de Recherche des Cordeliers, 75006, Paris, France
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Keywords	Type 2 diabetes Insulin resistance Inflammation NASH Lipotoxicity Steatosis
Language	English
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Snippet	Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple...
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SubjectTerms	Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology dissociation fatty acids fatty liver fibrosis Hepatitis - etiology Humans Inflammation Insulin Resistance Lipotoxicity NASH Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism noninsulin-dependent diabetes mellitus oxidative stress Risk Factors Steatosis Type 2 diabetes
Title	Steatosis and NASH in type 2 diabetes
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