Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes

G-quadruplex (G4) structures are key elements in the regulation of cancer cell proliferation and their targeting is deemed to be a promising strategy in anticancer therapy. A tandem application of ligand-based virtual screening (VS) calculations together with the experimental G-quadruplex on Oligo A...

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Veröffentlicht in:	Biochimica et biophysica acta. General subjects Jg. 1861; H. 5; S. 1341 - 1352
Hauptverfasser:	Musumeci, Domenica, Amato, Jussara, Zizza, Pasquale, Platella, Chiara, Cosconati, Sandro, Cingolani, Chiara, Biroccio, Annamaria, Novellino, Ettore, Randazzo, Antonio, Giancola, Concetta, Pagano, Bruno, Montesarchio, Daniela
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.05.2017
Schlagworte:	adverse effects Anticancer agents antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Binding Sites Cell Line, Transformed cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects chemotypes DNA DNA damage DNA, Neoplasm - chemistry DNA, Neoplasm - drug effects DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Dose-Response Relationship, Drug Drug Design Drug discovery fluorescent antibody technique G-quadruplex G-Quadruplexes - drug effects Guanosine - chemistry Guanosine - metabolism High-Throughput Screening Assays Humans Ligands Models, Molecular neoplasms Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology screening Small Molecule Libraries Structure-Activity Relationship Telomere - chemistry Telomere - drug effects Telomere - genetics Telomere - metabolism telomeres Time Factors Virtual screening Virtual screening Anticancer agents Drug discovery G-quadruplex
ISSN:	0304-4165, 1872-8006
Online-Zugang:	Volltext
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