“Coding” and “Decoding”: hypothesis for the regulatory mechanism involved in heparan sulfate biosynthesis

•Two major steps, “coding” and “decoding”, are involved in the biosynthesis of HS.•“Coding” is based on the distribution of sulfate moieties on the glucosamine.•“Code” is created by N-deacetylase/N-sulfotransferase, which has four isozymes.•C5-epimerase and O-sulfotransferases recognized the “Code”....

Full description

Saved in:

Bibliographic Details
Published in:	Carbohydrate research Vol. 428; pp. 1 - 7
Main Authors:	Zhang, Xu, Wang, Fengshan, Sheng, Juzheng
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 16.06.2016
Subjects:	Animals bioactive properties Biocatalysis biosynthesis Biosynthesis mechanism Biosynthetic Pathways C5-epimerase DNA enzymes glucosamine Glucosamine - chemistry Heparan sulfate Heparitin Sulfate - biosynthesis Heparitin Sulfate - chemistry Humans Isoenzymes - metabolism isozymes mammals Molecular Structure N-deacetylase/N-sulfotransferase O-sulfotransferase proteoglycans sulfates Sulfotransferases - metabolism Heparan sulfate C5-epimerase N-deacetylase/N-sulfotransferase O-sulfotransferase Biosynthesis mechanism
ISSN:	0008-6215, 1873-426X, 1873-426X
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!