In vitro neurotoxicity of salsolinol is attenuated by the presynaptic protein α-synuclein

Salsolinol (SALSO), a product from the reaction of dopamine (DA) with acetaldehyde, is found increased in dopaminergic neurons of Parkinson's disease (PD) patients. The administration of SALSO in rats causes myenteric neurodegeneration followed by the formation of deposits of the protein α-synu...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1862; no. 12; pp. 2835 - 2845
Main Authors:	do Carmo-Gonçalves, Phelippe, Coelho-Cerqueira, Eduardo, Cortines, Juliana R., de Souza, Theo Luiz Ferraz, Romão, Luciana, Follmer, Cristian
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.12.2018
Subjects:	4',6-diamidino-2-phenylindole acetaldehyde alpha-Synuclein - metabolism alpha-Synuclein - physiology Animals apoptosis Apoptosis - drug effects Calorimetry Caspase 3 - metabolism caspase-3 Cells, Cultured Chromatography, Gel Chromatography, High Pressure Liquid Dopamine Dopaminergic Neurons - drug effects Electrophoresis, Polyacrylamide Gel Enzyme Activation Humans hydrophobicity Isoquinolines - toxicity Mass Spectrometry Mice neurons neurotoxicity NMR Oligomers Oxidation-Reduction Parkinson disease Parkinson's disease patients protective effect Rats Salsolinol Spectrometry, Fluorescence Synapses - metabolism titration α-Synuclein Oligomers α-Synuclein Salsolinol NMR Dopamine Parkinson's disease
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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