Effect of gender on late-onset multiple sclerosis

Objectives: We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based on gender and race, since both have been reported as important modifiers of disease outcomes in MS. Methods: Patients wi...

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Vydané v:	Multiple sclerosis Ročník 18; číslo 10; s. 1472 - 1479
Hlavní autori:	Bove, Riley M, Healy, Brian, Augustine, Ann, Musallam, Alexander, Gholipour, Taha, Chitnis, Tanuja
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London, England SAGE Publications 01.10.2012 Sage Publications Sage Publications Ltd
Predmet:	Adult Age of Onset Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Humans Incidence Male Medical sciences Middle Aged Multiple Sclerosis - epidemiology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Sex Factors geriatrics progression menopause female multiple sclerosis disability Disability Nervous system diseases Multiple sclerosis Menopause Central nervous system disease Sex Degenerative disease Inflammatory disease Geriatrics
ISSN:	1352-4585, 1477-0970, 1477-0970
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Abstract	Objectives: We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based on gender and race, since both have been reported as important modifiers of disease outcomes in MS. Methods: Patients with LOMS and AOMS were compared in terms of demographic characteristics and disease course characteristics. Combined effects were investigated with a logistic regression model. Time from disease onset to sustained Expanded Disability Status Scale (EDSS) score of 6 was investigated using an extension of log-rank test appropriate for interval-censored data. Results: Some 7.96% of 4273 patients studied had an onset of MS after the age of 50 years (LOMS), and 1.33% experienced an onset after age 60. Progressive onset was more common in LOMS relative to AOMS. The proportion of women with progressive-onset disease was similar in AOMS and LOMS. Time to EDSS 6 was delayed in AOMS females compared with males; however, it was similar between males and females in the LOMS group. Conclusions: Women with LOMS have a different trajectory in terms of disease progression than women with AOMS. The effect of menopause combined with race/ethnicity on the MS disease course requires further investigation.
AbstractList	Objectives: We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based on gender and race, since both have been reported as important modifiers of disease outcomes in MS. Methods: Patients with LOMS and AOMS were compared in terms of demographic characteristics and disease course characteristics. Combined effects were investigated with a logistic regression model. Time from disease onset to sustained Expanded Disability Status Scale (EDSS) score of 6 was investigated using an extension of log-rank test appropriate for interval-censored data. Results: Some 7.96% of 4273 patients studied had an onset of MS after the age of 50 years (LOMS), and 1.33% experienced an onset after age 60. Progressive onset was more common in LOMS relative to AOMS. The proportion of women with progressive-onset disease was similar in AOMS and LOMS. Time to EDSS 6 was delayed in AOMS females compared with males; however, it was similar between males and females in the LOMS group. Conclusions: Women with LOMS have a different trajectory in terms of disease progression than women with AOMS. The effect of menopause combined with race/ethnicity on the MS disease course requires further investigation. We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based on gender and race, since both have been reported as important modifiers of disease outcomes in MS.OBJECTIVESWe aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based on gender and race, since both have been reported as important modifiers of disease outcomes in MS.Patients with LOMS and AOMS were compared in terms of demographic characteristics and disease course characteristics. Combined effects were investigated with a logistic regression model. Time from disease onset to sustained Expanded Disability Status Scale (EDSS) score of 6 was investigated using an extension of log-rank test appropriate for interval-censored data.METHODSPatients with LOMS and AOMS were compared in terms of demographic characteristics and disease course characteristics. Combined effects were investigated with a logistic regression model. Time from disease onset to sustained Expanded Disability Status Scale (EDSS) score of 6 was investigated using an extension of log-rank test appropriate for interval-censored data.Some 7.96% of 4273 patients studied had an onset of MS after the age of 50 years (LOMS), and 1.33% experienced an onset after age 60. Progressive onset was more common in LOMS relative to AOMS. The proportion of women with progressive-onset disease was similar in AOMS and LOMS. Time to EDSS 6 was delayed in AOMS females compared with males; however, it was similar between males and females in the LOMS group.RESULTSSome 7.96% of 4273 patients studied had an onset of MS after the age of 50 years (LOMS), and 1.33% experienced an onset after age 60. Progressive onset was more common in LOMS relative to AOMS. The proportion of women with progressive-onset disease was similar in AOMS and LOMS. Time to EDSS 6 was delayed in AOMS females compared with males; however, it was similar between males and females in the LOMS group.Women with LOMS have a different trajectory in terms of disease progression than women with AOMS. The effect of menopause combined with race/ethnicity on the MS disease course requires further investigation.CONCLUSIONSWomen with LOMS have a different trajectory in terms of disease progression than women with AOMS. The effect of menopause combined with race/ethnicity on the MS disease course requires further investigation. We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based on gender and race, since both have been reported as important modifiers of disease outcomes in MS. Patients with LOMS and AOMS were compared in terms of demographic characteristics and disease course characteristics. Combined effects were investigated with a logistic regression model. Time from disease onset to sustained Expanded Disability Status Scale (EDSS) score of 6 was investigated using an extension of log-rank test appropriate for interval-censored data. Some 7.96% of 4273 patients studied had an onset of MS after the age of 50 years (LOMS), and 1.33% experienced an onset after age 60. Progressive onset was more common in LOMS relative to AOMS. The proportion of women with progressive-onset disease was similar in AOMS and LOMS. Time to EDSS 6 was delayed in AOMS females compared with males; however, it was similar between males and females in the LOMS group. Women with LOMS have a different trajectory in terms of disease progression than women with AOMS. The effect of menopause combined with race/ethnicity on the MS disease course requires further investigation. We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based on gender and race, since both have been reported as important modifiers of disease outcomes in MS. Patients with LOMS and AOMS were compared in terms of demographic characteristics and disease course characteristics. Combined effects were investigated with a logistic regression model. Time from disease onset to sustained Expanded Disability Status Scale (EDSS) score of 6 was investigated using an extension of log-rank test appropriate for interval-censored data. Some 7.96% of 4273 patients studied had an onset of MS after the age of 50 years (LOMS), and 1.33% experienced an onset after age 60. Progressive onset was more common in LOMS relative to AOMS. The proportion of women with progressive-onset disease was similar in AOMS and LOMS. Time to EDSS 6 was delayed in AOMS females compared with males; however, it was similar between males and females in the LOMS group. Women with LOMS have a different trajectory in terms of disease progression than women with AOMS. The effect of menopause combined with race/ethnicity on the MS disease course requires further investigation.
Author	Gholipour, Taha Musallam, Alexander Chitnis, Tanuja Bove, Riley M Healy, Brian Augustine, Ann
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Cites_doi	10.1007/s100720170011 10.1016/S0079-6123(09)17516-7 10.1111/j.1468-1331.2009.02850.x 10.1111/j.1468-1331.2004.01103.x 10.1212/01.wnl.0000256732.36565.4a 10.1177/135245859700300105 10.1002/ana.20703 10.1016/j.jns.2010.12.024 10.1007/s00415-009-5063-0 10.4049/jimmunol.1001322 10.1212/01.wnl.0000237475.01655.9d 10.1016/S1474-4422(06)70581-6 10.1016/S0895-4356(98)00119-X 10.2307/2530698 10.1212/WNL.56.3.422 10.1007/s10072-004-0339-8 10.1212/WNL.0b013e3181af33cf 10.1212/WNL.42.10.1907 10.1212/WNL.0b013e31821e559d 10.2741/3543 10.1038/nrneurol.2011.61 10.1111/j.1468-1331.2008.02431.x 10.1111/j.1468-1331.2006.01342.x 10.1016/j.jns.2005.08.006 10.1111/j.1600-0404.1985.tb01547.x 10.1177/107385840100700310 10.1016/j.jns.2009.05.028 10.1159/000213192 10.1159/000117073 10.1523/JNEUROSCI.22-07-02451.2002 10.1007/s10072-004-0335-z 10.1016/j.smim.2009.08.003 10.1016/j.jneuroim.2011.03.003 10.1177/1352458508101933 10.1007/BF00920623 10.1038/nature02661 10.1016/j.clineuro.2005.11.016 10.1212/WNL.33.12.1537 10.1001/archneurol.2008.541 10.1038/nature10251 10.1212/WNL.46.4.907 10.1097/01.nrl.0000250946.87145.cf 10.1046/j.1532-5415.2001.49038.x 10.1212/WNL.51.3.765 10.1093/brain/113.6.1597 10.1007/s00415-008-0778-x 10.1212/WNL.33.11.1444 10.1212/01.wnl.0000208505.81912.82
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Keywords	geriatrics progression menopause female multiple sclerosis disability Disability Nervous system diseases Multiple sclerosis Menopause Central nervous system disease Sex Degenerative disease Inflammatory disease Geriatrics
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References	Phadke 1990; 113 Wundes, Amtmann, Brown, Christian 2011; 13 Chitnis, Glanz, Jaffin, Healy 2009; 15 Chitnis 2006; 12 Gholipour, Healy, Baruch, Weiner, Chitnis 2011; 76 Finkelstein 1986; 42 Ramagopalan, Byrnes, Orton 2010; 17 Ramagopalan, Yee, Dyment 2009; 73 Papenfuss, Powell, McClain 2011; 186 Azzimondi, Stracciari, Rinaldi, D’Alessandro, Pazzaglia 1994; 34 de Seze, Delalande, Michelin 2005; 12 Noseworthy, Paty, Wonnacott, Feasby, Ebers 1983; 33 Dean, Kurtzke 1970; 95 Tortorella, Bellacosa, Paolicelli 2005; 239 Lyon-Caen, Izquierdo, Marteau, Lhermitte, Castaigne, Hauw 1985; 72 Nicot 2009; 14 Runmarker, Andersson, Oden, Andersen 1994; 241 Healy, Engler, Gholipour, Weiner, Bakshi, Chitnis 2011 Voskuhl, Palaszynski 2001; 7 Sawcer, Hellenthal, Pirinen 2011; 476 Greer, McCombe 2011; 234 Gold, Voskuhl 2009; 175 Mowry, Pesic, Grimes, Deen, Bacchetti, Waubant 2009; 256 Pugliatti, Rosati, Carton 2006; 13 Delalande, De Seze, Ferriby, Stojkovic, Vermersch 2002; 158 Zuvich, McCauley, Pericak-Vance, Haines 2009; 21 White, Swingler, Compston 1990; 36 Ramagopalan, Valdar, Criscuoli 2009; 16 Martinelli, Rodegher, Moiola, Comi 2004; 25 Rosati 2001; 22 Ghezzi, Deplano, Faroni 1997; 3 Kantarci, Siva, Eraksoy 1998; 51 Stankoff, Mrejen, Tourbah 2007; 68 Ruggieri, Iannetti, Polizzi, Pavone, Grimaldi 2004; 25 Gold, Voskuhl 2009; 286 Sim, Zhao, Penderis, Franklin 2002; 22 Kurtzke 1983; 33 Cree, Reich, Khan 2009; 66 Vukusic, Confavreux 2006; 108 Lublin, Reingold 1996; 46 Lu, Pan, Kao 2004; 429 Tremlett, Devonshire 2006; 67 Kato, Toniolo, Akhmedkhanov, Koenig, Shore, Zeleniuch-Jacquotte 1998; 51 Marrie, Cutter, Tyry, Vollmer, Campagnolo 2006; 66 Polliack, Barak, Achiron 2001; 49 Filippi, Wolinsky, Sormani, Comi 2001; 56 Orton, Herrera, Yee 2006; 5 Hooge, Redekop 1992; 42 Kis, Rumberg, Berlit 2008; 255 Benedict, Zivadinov 2011; 7 Dean G (bibr33-1352458512438236) 1970; 95 bibr50-1352458512438236 bibr34-1352458512438236 bibr4-1352458512438236 bibr26-1352458512438236 bibr41-1352458512438236 bibr24-1352458512438236 bibr43-1352458512438236 bibr2-1352458512438236 bibr16-1352458512438236 bibr3-1352458512438236 bibr51-1352458512438236 bibr25-1352458512438236 bibr42-1352458512438236 Delalande S (bibr17-1352458512438236) 2002; 158 bibr31-1352458512438236 bibr36-1352458512438236 bibr23-1352458512438236 bibr44-1352458512438236 bibr49-1352458512438236 bibr15-1352458512438236 bibr28-1352458512438236 bibr18-1352458512438236 bibr5-1352458512438236 bibr10-1352458512438236 bibr47-1352458512438236 bibr20-1352458512438236 Wundes A (bibr45-1352458512438236) 2011; 13 bibr39-1352458512438236 bibr13-1352458512438236 bibr8-1352458512438236 bibr11-1352458512438236 bibr29-1352458512438236 bibr30-1352458512438236 bibr37-1352458512438236 bibr21-1352458512438236 bibr46-1352458512438236 bibr38-1352458512438236 bibr7-1352458512438236 bibr12-1352458512438236 bibr1-1352458512438236 bibr19-1352458512438236 bibr22-1352458512438236 bibr6-1352458512438236 bibr32-1352458512438236 bibr35-1352458512438236 bibr48-1352458512438236 bibr9-1352458512438236 bibr14-1352458512438236 bibr27-1352458512438236 bibr40-1352458512438236
References_xml	– volume: 34 start-page: 332 year: 1994 end-page: 336 article-title: Multiple sclerosis with very late onset: report of six cases and review of the literature publication-title: Eur Neurol – volume: 25 start-page: S326 issue: Suppl 4 year: 2004 end-page: S335 article-title: Multiple sclerosis in children under 10 years of age publication-title: Neurol Sci – volume: 429 start-page: 883 year: 2004 end-page: 891 article-title: Gene regulation and DNA damage in the ageing human brain publication-title: Nature – volume: 12 start-page: 299 year: 2006 end-page: 310 article-title: Pediatric multiple sclerosis publication-title: Neurologist – volume: 21 start-page: 328 year: 2009 end-page: 333 article-title: Genetics and pathogenesis of multiple sclerosis publication-title: Semin Immunol – volume: 42 start-page: 1907 year: 1992 end-page: 1910 article-title: Multiple sclerosis with very late onset publication-title: Neurology – volume: 286 start-page: 99 year: 2009 end-page: 103 article-title: Estrogen treatment in multiple sclerosis publication-title: J Neurol Sci – volume: 25 start-page: S350 issue: Suppl 4 year: 2004 end-page: 355 article-title: Late onset multiple sclerosis: clinical characteristics, prognostic factors and differential diagnosis publication-title: Neurol Sci – volume: 42 start-page: 845 year: 1986 end-page: 854 article-title: A proportional hazards model for interval-censored failure time data publication-title: Biometrics – volume: 12 start-page: 241 year: 2005 end-page: 244 article-title: Brain MRI in late-onset multiple sclerosis publication-title: Eur J Neurol – volume: 51 start-page: 765 year: 1998 end-page: 772 article-title: Survival and predictors of disability in Turkish MS patients. Turkish Multiple Sclerosis Study Group (TUMSSG) publication-title: Neurology – volume: 68 start-page: 779 year: 2007 end-page: 781 article-title: Age at onset determines the occurrence of the progressive phase of multiple sclerosis publication-title: Neurology – volume: 256 start-page: 1061 year: 2009 end-page: 1066 article-title: Clinical predictors of early second event in patients with clinically isolated syndrome publication-title: J Neurol – volume: 46 start-page: 907 year: 1996 end-page: 911 article-title: Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis publication-title: Neurology – volume: 239 start-page: 95 year: 2005 end-page: 99 article-title: Age-related gadolinium-enhancement of MRI brain lesions in multiple sclerosis publication-title: J Neurol Sci – volume: 66 start-page: 1235 year: 2006 end-page: 1240 article-title: Does multiple sclerosis-associated disability differ between races? publication-title: Neurology – volume: 17 start-page: 634 year: 2010 end-page: 637 article-title: Sex ratio of multiple sclerosis and clinical phenotype publication-title: Eur J Neurol – volume: 175 start-page: 239 year: 2009 end-page: 251 article-title: Estrogen and testosterone therapies in multiple sclerosis publication-title: Prog Brain Res – volume: 3 start-page: 43 year: 1997 end-page: 46 article-title: Multiple sclerosis in childhood: clinical features of 149 cases publication-title: Mult Scler – volume: 49 start-page: 168 year: 2001 end-page: 171 article-title: Late-onset multiple sclerosis publication-title: J Am Geriatr Soc – volume: 13 start-page: 700 year: 2006 end-page: 722 article-title: The epidemiology of multiple sclerosis in Europe publication-title: Eur J Neurol – volume: 113 start-page: 1597 issue: Pt 6 year: 1990 end-page: 1628 article-title: Clinical aspects of multiple sclerosis in north-east Scotland with particular reference to its course and prognosis publication-title: Brain – volume: 5 start-page: 932 year: 2006 end-page: 936 article-title: Sex ratio of multiple sclerosis in Canada: a longitudinal study publication-title: Lancet Neurol – volume: 7 start-page: 332 year: 2011 end-page: 342 article-title: Risk factors for and management of cognitive dysfunction in multiple sclerosis publication-title: Nat Rev Neurol – volume: 76 start-page: 1996 year: 2011 end-page: 2001 article-title: Demographic and clinical characteristics of malignant multiple sclerosis publication-title: Neurology – volume: 158 start-page: 1082 year: 2002 end-page: 1087 article-title: Late onset multiple sclerosis publication-title: Rev Neurol (Paris) – volume: 72 start-page: 56 year: 1985 end-page: 60 article-title: Late onset multiple sclerosis. A clinical study of 16 pathologically proven cases publication-title: Acta Neurol Scand – volume: 241 start-page: 597 year: 1994 end-page: 604 article-title: Prediction of outcome in multiple sclerosis based on multivariate models publication-title: J Neurol – volume: 66 start-page: 226 year: 2009 end-page: 233 article-title: Modification of multiple sclerosis phenotypes by African ancestry at HLA publication-title: Arch Neurol – volume: 73 start-page: 602 year: 2009 end-page: 605 article-title: Parent-of-origin effect in multiple sclerosis: observations from interracial matings publication-title: Neurology – volume: 7 start-page: 258 year: 2001 end-page: 270 article-title: Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis publication-title: Neuroscientist – volume: 255 start-page: 697 year: 2008 end-page: 702 article-title: Clinical characteristics of patients with late-onset multiple sclerosis publication-title: J Neurol – volume: 16 start-page: 342 year: 2009 end-page: 347 article-title: Age of puberty and the risk of multiple sclerosis: a population based study publication-title: Eur J Neurol – volume: 33 start-page: 1444 year: 1983 end-page: 1452 article-title: Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS) publication-title: Neurology – volume: 14 start-page: 4477 year: 2009 end-page: 4515 article-title: Gender and sex hormones in multiple sclerosis pathology and therapy publication-title: Front Biosci – volume: 51 start-page: 1271 year: 1998 end-page: 1276 article-title: Prospective study of factors influencing the onset of natural menopause publication-title: J Clin Epidemiol – volume: 186 start-page: 3346 year: 2011 end-page: 3355 article-title: Estriol generates tolerogenic dendritic cells in vivo that protect against autoimmunity publication-title: J Immunol – volume: 22 start-page: 2451 year: 2002 end-page: 2459 article-title: The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation publication-title: J Neurosci – volume: 56 start-page: 422 year: 2001 end-page: 423 article-title: Enhancement frequency decreases with increasing age in relapsing-remitting multiple sclerosis publication-title: Neurology – volume: 33 start-page: 1537 year: 1983 end-page: 1544 article-title: Multiple sclerosis after age 50 publication-title: Neurology – volume: 95 start-page: 232 year: 1970 end-page: 233 article-title: A critical age for the acquisition of multiple sclerosis publication-title: Trans Am Neurol Assoc – volume: 108 start-page: 266 year: 2006 end-page: 270 article-title: Pregnancy and multiple sclerosis: the children of PRIMS publication-title: Clin Neurol Neurosurg – volume: 234 start-page: 7 year: 2011 end-page: 18 article-title: Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms publication-title: J Neuroimmunol – year: 2011 article-title: Accounting for disease-modifying therapy in models of clinical progression in multiple sclerosis publication-title: J Neurol Sci – volume: 22 start-page: 117 year: 2001 end-page: 139 article-title: The prevalence of multiple sclerosis in the world: an update publication-title: Neurol Sci – volume: 15 start-page: 627 year: 2009 end-page: 631 article-title: Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States publication-title: Mult Scler – volume: 67 start-page: 954 year: 2006 end-page: 959 article-title: Is late-onset multiple sclerosis associated with a worse outcome? publication-title: Neurology – volume: 36 start-page: 159 year: 1990 end-page: 164 article-title: Features of multiple sclerosis in older patients in South Wales publication-title: Gerontology – volume: 476 start-page: 214 year: 2011 end-page: 219 article-title: Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis publication-title: Nature – volume: 13 start-page: 47 year: 2011 article-title: Menopause in women with multiple sclerosis publication-title: International Journal of MS Care – ident: bibr1-1352458512438236 doi: 10.1007/s100720170011 – ident: bibr6-1352458512438236 doi: 10.1016/S0079-6123(09)17516-7 – volume: 158 start-page: 1082 year: 2002 ident: bibr17-1352458512438236 publication-title: Rev Neurol (Paris) – ident: bibr43-1352458512438236 doi: 10.1111/j.1468-1331.2009.02850.x – ident: bibr29-1352458512438236 doi: 10.1111/j.1468-1331.2004.01103.x – ident: bibr26-1352458512438236 doi: 10.1212/01.wnl.0000256732.36565.4a – ident: bibr13-1352458512438236 doi: 10.1177/135245859700300105 – ident: bibr32-1352458512438236 doi: 10.1002/ana.20703 – ident: bibr30-1352458512438236 doi: 10.1016/j.jns.2010.12.024 – ident: bibr10-1352458512438236 doi: 10.1007/s00415-009-5063-0 – volume: 95 start-page: 232 year: 1970 ident: bibr33-1352458512438236 publication-title: Trans Am Neurol Assoc – ident: bibr7-1352458512438236 doi: 10.4049/jimmunol.1001322 – ident: bibr19-1352458512438236 doi: 10.1212/01.wnl.0000237475.01655.9d – ident: bibr3-1352458512438236 doi: 10.1016/S1474-4422(06)70581-6 – ident: bibr44-1352458512438236 doi: 10.1016/S0895-4356(98)00119-X – ident: bibr37-1352458512438236 doi: 10.2307/2530698 – ident: bibr41-1352458512438236 doi: 10.1212/WNL.56.3.422 – ident: bibr38-1352458512438236 doi: 10.1007/s10072-004-0339-8 – ident: bibr11-1352458512438236 doi: 10.1212/WNL.0b013e3181af33cf – ident: bibr22-1352458512438236 doi: 10.1212/WNL.42.10.1907 – ident: bibr31-1352458512438236 doi: 10.1212/WNL.0b013e31821e559d – ident: bibr9-1352458512438236 doi: 10.2741/3543 – ident: bibr49-1352458512438236 doi: 10.1038/nrneurol.2011.61 – ident: bibr4-1352458512438236 doi: 10.1111/j.1468-1331.2008.02431.x – ident: bibr2-1352458512438236 doi: 10.1111/j.1468-1331.2006.01342.x – ident: bibr28-1352458512438236 doi: 10.1016/j.jns.2005.08.006 – ident: bibr24-1352458512438236 doi: 10.1111/j.1600-0404.1985.tb01547.x – volume: 13 start-page: 47 year: 2011 ident: bibr45-1352458512438236 publication-title: International Journal of MS Care – ident: bibr8-1352458512438236 doi: 10.1177/107385840100700310 – ident: bibr42-1352458512438236 doi: 10.1016/j.jns.2009.05.028 – ident: bibr23-1352458512438236 doi: 10.1159/000213192 – ident: bibr21-1352458512438236 doi: 10.1159/000117073 – ident: bibr39-1352458512438236 doi: 10.1523/JNEUROSCI.22-07-02451.2002 – ident: bibr14-1352458512438236 doi: 10.1007/s10072-004-0335-z – ident: bibr48-1352458512438236 doi: 10.1016/j.smim.2009.08.003 – ident: bibr50-1352458512438236 doi: 10.1016/j.jneuroim.2011.03.003 – ident: bibr12-1352458512438236 doi: 10.1177/1352458508101933 – ident: bibr25-1352458512438236 doi: 10.1007/BF00920623 – ident: bibr40-1352458512438236 doi: 10.1038/nature02661 – ident: bibr5-1352458512438236 doi: 10.1016/j.clineuro.2005.11.016 – ident: bibr20-1352458512438236 doi: 10.1212/WNL.33.12.1537 – ident: bibr47-1352458512438236 doi: 10.1001/archneurol.2008.541 – ident: bibr51-1352458512438236 doi: 10.1038/nature10251 – ident: bibr35-1352458512438236 doi: 10.1212/WNL.46.4.907 – ident: bibr15-1352458512438236 doi: 10.1097/01.nrl.0000250946.87145.cf – ident: bibr18-1352458512438236 doi: 10.1046/j.1532-5415.2001.49038.x – ident: bibr27-1352458512438236 doi: 10.1212/WNL.51.3.765 – ident: bibr16-1352458512438236 doi: 10.1093/brain/113.6.1597 – ident: bibr34-1352458512438236 doi: 10.1007/s00415-008-0778-x – ident: bibr36-1352458512438236 doi: 10.1212/WNL.33.11.1444 – ident: bibr46-1352458512438236 doi: 10.1212/01.wnl.0000208505.81912.82
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Snippet	Objectives: We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic... We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort,...
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SubjectTerms	Adult Age of Onset Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Humans Incidence Male Medical sciences Middle Aged Multiple Sclerosis - epidemiology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Sex Factors
Title	Effect of gender on late-onset multiple sclerosis
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