Effect of gender on late-onset multiple sclerosis

Objectives: We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based on gender and race, since both have been reported as important modifiers of disease outcomes in MS. Methods: Patients wi...

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Bibliographic Details
Published in:Multiple sclerosis Vol. 18; no. 10; pp. 1472 - 1479
Main Authors: Bove, Riley M, Healy, Brian, Augustine, Ann, Musallam, Alexander, Gholipour, Taha, Chitnis, Tanuja
Format: Journal Article
Language:English
Published: London, England SAGE Publications 01.10.2012
Sage Publications
Sage Publications Ltd
Subjects:
Adult
Age of Onset
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Progression
Female
Humans
Incidence
Male
Medical sciences
Middle Aged
Multiple Sclerosis - epidemiology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Sex Factors
geriatrics
progression
menopause
female
multiple sclerosis
disability
Disability
Nervous system diseases
Multiple sclerosis
Menopause
Central nervous system disease
Sex
Degenerative disease
Inflammatory disease
Geriatrics
ISSN:1352-4585, 1477-0970, 1477-0970
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Summary:Objectives: We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based on gender and race, since both have been reported as important modifiers of disease outcomes in MS. Methods: Patients with LOMS and AOMS were compared in terms of demographic characteristics and disease course characteristics. Combined effects were investigated with a logistic regression model. Time from disease onset to sustained Expanded Disability Status Scale (EDSS) score of 6 was investigated using an extension of log-rank test appropriate for interval-censored data. Results: Some 7.96% of 4273 patients studied had an onset of MS after the age of 50 years (LOMS), and 1.33% experienced an onset after age 60. Progressive onset was more common in LOMS relative to AOMS. The proportion of women with progressive-onset disease was similar in AOMS and LOMS. Time to EDSS 6 was delayed in AOMS females compared with males; however, it was similar between males and females in the LOMS group. Conclusions: Women with LOMS have a different trajectory in terms of disease progression than women with AOMS. The effect of menopause combined with race/ethnicity on the MS disease course requires further investigation.
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ISSN:1352-4585
1477-0970
1477-0970
DOI:10.1177/1352458512438236