The distal β‐globin CACCC box is required for maximal stimulation of the β‐globin gene by EKLF

Summary The transcription factor erythroid Kruppel‐like factor (EKLF) specifically activates the β‐globin gene by interacting with the proximal β‐globin CACCC box, a known hot spot for thalassaemia mutations. This study investigated whether EKLF could also bind to, and activate from, the distal CACC...

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Bibliographic Details
Published in:	British journal of haematology Vol. 127; no. 1; pp. 114 - 117
Main Authors:	Marini, Maria Giuseppina, Asunis, Isadora, Porcu, Loredana, Salgo, Maria Giulia, Loi, Maria Giuseppina, Brucchietti, Arianna, Cao, Antonio, Moi, Paolo
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01.10.2004 Blackwell
Subjects:	Anemias. Hemoglobinopathies Animals beta-Thalassemia - genetics beta-Thalassemia - metabolism Biological and medical sciences Cell Line Diseases of red blood cells DNA mutation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA‐binding proteins ex vivo expression Gene Expression Regulation Globins - genetics Hematologic and hematopoietic diseases Humans Kruppel-Like Transcription Factors Medical sciences Mice Promoter Regions, Genetic transcription control Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation β‐thalassaemia Hemoglobinopathy Hematology Transcription Beta-Peptide chain DNA binding protein Stimulation Hemopathy β-thalassaemia Genetic disease Globin Transcription factor EKLF transcription control Regulation(control) Hemolytic anemia Ex vivo Gene β-Thalassemia DNA Distal DNA mutation Genetics Mutation ex vivo expression DNA-binding proteins
ISSN:	0007-1048, 1365-2141
Online Access:	Get full text
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