Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection

Clinical and virologic manifestations of genital herpes simplex virus type 2 (HSV-2) infection vary widely. We examined frequencies of single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) 2, 3, 4, and 9 in a prospective cohort of 128 HSV-2-infected persons whose viral shedding and le...

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Veröffentlicht in:	The Journal of infectious diseases Jg. 196; H. 4; S. 505
Hauptverfasser:	Bochud, Pierre-Yves, Magaret, Amalia S, Koelle, David M, Aderem, Alan, Wald, Anna
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.08.2007
Schlagworte:	Adult Aged Cohort Studies Disease Progression DNA, Viral - genetics Female Genetic Predisposition to Disease Haplotypes Herpes Genitalis - genetics Herpes Genitalis - pathology Herpes Genitalis - virology Herpesvirus 2, Human - genetics Herpesvirus 2, Human - isolation & purification Herpesvirus 2, Human - physiology Humans Male Polymerase Chain Reaction Polymorphism, Genetic Prospective Studies Toll-Like Receptor 2 - genetics
ISSN:	0022-1899
Online-Zugang:	Weitere Angaben
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