Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection

Clinical and virologic manifestations of genital herpes simplex virus type 2 (HSV-2) infection vary widely. We examined frequencies of single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) 2, 3, 4, and 9 in a prospective cohort of 128 HSV-2-infected persons whose viral shedding and le...

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Published in:The Journal of infectious diseases Vol. 196; no. 4; p. 505
Main Authors: Bochud, Pierre-Yves, Magaret, Amalia S, Koelle, David M, Aderem, Alan, Wald, Anna
Format: Journal Article
Language:English
Published: United States 15.08.2007
Subjects:
Adult
Aged
Cohort Studies
Disease Progression
DNA, Viral - genetics
Female
Genetic Predisposition to Disease
Haplotypes
Herpes Genitalis - genetics
Herpes Genitalis - pathology
Herpes Genitalis - virology
Herpesvirus 2, Human - genetics
Herpesvirus 2, Human - isolation & purification
Herpesvirus 2, Human - physiology
Humans
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Prospective Studies
Toll-Like Receptor 2 - genetics
ISSN:0022-1899
Online Access:Get more information
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Summary:Clinical and virologic manifestations of genital herpes simplex virus type 2 (HSV-2) infection vary widely. We examined frequencies of single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) 2, 3, 4, and 9 in a prospective cohort of 128 HSV-2-infected persons whose viral shedding and lesion frequency was measured by daily sampling from genital secretions. Two TLR2 haplotypes (2 and 4) were associated with increased lesional (P=.008 and P=.03) and shedding (P=.02 and P=.001) rates. An SNP in haplotype 2 (-15607A/G) was also associated with shedding (P=.01) and lesional (P=.008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection.
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ISSN:0022-1899
DOI:10.1086/519693