Cholinergic alterations by exposure to pesticides used in control vector: Guppies fish (Poecilia reticulta) as biological model

Spinosad and temephos are two of the most used pesticides in Mexico for the control of vector causing disease such as dengue, chikungunya and Zika. The aim of this study was to compare the neurotoxic effects of these two pesticides using guppy fish (Poecilia reticulata) as a model organism. Guppies...

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Bibliographic Details
Published in:International journal of environmental health research Vol. 28; no. 1; pp. 79 - 89
Main Authors: Toledo-Ibarra, G. A., Rodríguez-Sánchez, E. J., Ventura-Ramón, H. G., Díaz-Resendiz, K. J. G., Girón-Pérez, M. I.
Format: Journal Article
Language:English
Published: England Taylor & Francis 01.02.2018
Taylor & Francis LLC
Subjects:
Acetylcholinesterase
Acetylcholinesterase - metabolism
Animals
cholinergic agents
Cholinesterase Inhibitors - toxicity
Dengue fever
Disease control
Drug Combinations
Exposure
Fish
Insecticides
Insecticides - toxicity
Macrolides - toxicity
Male
Models, Animal
Muscles
Muscles - drug effects
Muscles - enzymology
Neurotoxicity
Pesticides
Poecilia - metabolism
Spinosad
Temefos - toxicity
Vector control
Vector-borne diseases
Viral diseases
Water Pollutants, Chemical - toxicity
Mexico
cholinergic agents
neurotoxicity
Vector control
pesticides
ISSN:0960-3123, 1369-1619, 1369-1619
Online Access:Get full text
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Summary:Spinosad and temephos are two of the most used pesticides in Mexico for the control of vector causing disease such as dengue, chikungunya and Zika. The aim of this study was to compare the neurotoxic effects of these two pesticides using guppy fish (Poecilia reticulata) as a model organism. Guppies were exposed for 7 and 21 days to technical grade temephos and spinosad at 1.0 and 0.07 g/L, respectively, (10 and 0.5 mg/L of active substance; concentrations recommended by the Ministery of Health of the State (Secretaría de Salud de Nayarit (SSN) Mexico)). Subsequently, acetylcholinesterase activity (AChE) and acetylcholine concentrations (ACh) in muscle tissue were determined. Temephos exposure decreased AChE activity and increased ACh concentration, whereas exposure to spinosad only increased ACh concentration. Though cholinergic alterations were more severe in fish exposed to temephos, both pesticides were equally lethal during the first seven days after exposure. Nonetheless, temephos was more lethal after 21 days.
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ISSN:0960-3123
1369-1619
1369-1619
DOI:10.1080/09603123.2018.1429577