Non-Coding RNA Editing in Cancer Pathogenesis

In the last two decades, RNA post-transcriptional modifications, including RNA editing, have been the subject of increasing interest among the scientific community. The efforts of the Human Genome Project combined with the development of new sequencing technologies and dedicated bioinformatic approa...

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Vydané v:Cancers Ročník 12; číslo 7; s. 1845
Hlavní autori: Romano, Giulia, Saviana, Michela, Le, Patricia, Li, Howard, Micalo, Lavender, Nigita, Giovanni, Acunzo, Mario, Nana-Sinkam, Patrick
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI 08.07.2020
Predmet:
Review
non-coding RNA
cancer
editing
ISSN:2072-6694, 2072-6694
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Popis
Shrnutí:In the last two decades, RNA post-transcriptional modifications, including RNA editing, have been the subject of increasing interest among the scientific community. The efforts of the Human Genome Project combined with the development of new sequencing technologies and dedicated bioinformatic approaches created to detect and profile RNA transcripts have served to further our understanding of RNA editing. Investigators have determined that non-coding RNA (ncRNA) A-to-I editing is often deregulated in cancer. This discovery has led to an increased number of published studies in the field. However, the eventual clinical application for these findings remains a work in progress. In this review, we provide an overview of the ncRNA editing phenomenon in cancer. We discuss the bioinformatic strategies for RNA editing detection as well as the potential roles for ncRNA A to I editing in tumor immunity and as clinical biomarkers.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers12071845