Surgery in recurrent ovarian cancer

Ovarian cancer is one of the most challenging diseases in gynecologic oncology. The presentation of frequent recurrences requires the establishment and further development of therapy standards for this patient group. Surgery is crucial in the therapy of patients with primary ovarian cancer, and the...

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Veröffentlicht in:Cancer Jg. 125; H. S24; S. 4598 - 4601
Hauptverfasser: Sehouli, Jalid, Grabowski, Jacek P.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Wiley Subscription Services, Inc 15.12.2019
Schlagworte:
Cancer
Clinical trials
Disease control
Female
Humans
Neoplasm Recurrence, Local
Oncology
outcome
Ovarian cancer
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Patients
predictive factors
recurrence
Surgery
Therapy
Tumors
recurrence
ovarian cancer
outcome
predictive factors
surgery
ISSN:0008-543X, 1097-0142, 1097-0142
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Zusammenfassung:Ovarian cancer is one of the most challenging diseases in gynecologic oncology. The presentation of frequent recurrences requires the establishment and further development of therapy standards for this patient group. Surgery is crucial in the therapy of patients with primary ovarian cancer, and the postoperative residual tumor mass is the most relevant clinical prognostic factor. The surgical management of recurrent disease is still subject to an emotional international discussion. Only a few prospective clinical trials focused on the effects of surgery in relapsed ovarian cancer have been published. The available data show improvements in the prognosis due to complete cytoreduction in the setting of recurrence. However, the selection of eligible patients is the essential issue. Therefore, the establishment of reliable predictive factors for complete tumor resection as well as a definition of the group of patients who might profit from this approach remains a field for research. Further randomized trials designed to develop and incorporate operative standards for recurrent ovarian cancer should follow. Surgery is an option in recurrent ovarian cancer. The selection of patients with recurrent ovarian cancer who may profit from a surgical approach remains crucial.
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ISSN:0008-543X
1097-0142
1097-0142
DOI:10.1002/cncr.32511