An inflammatory T-cell-stromal axis contributes to hematopoietic stem/progenitor cell failure and clonal evolution in human myelodysplastic syndrome

Myelodysplastic syndrome (MDS) is characterized by bone marrow failure, clonal evolution and leukemic progression, but the pathophysiologic processes driving these events remain incompletely understood. Here, by establishing a comprehensive single-cell transcriptional taxonomy of human MDS, we revea...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 10041 - 22
Main Authors:	Chen, Lanpeng, Bian, Yujie, Pronk, Eline, van Dijk, Claire, V.D. van Tienhoven, Tim, Hoogenboezem, Remco M., Bindels, Eric M., Bosch, Dennis, Fazeli, Sadaf, de Graaf, Aniek O., Westers, Theresia M., Kholmatov, Maksim, Zaugg, Judith B., Moura, Pedro L., Hellström-Lindberg, Eva, van de Loosdrecht, Arjan A., Jansen, Joop H., Sanders, Mathijs A., Raaijmakers, Marc H.G.P.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.11.2025 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/100 13/106 13/109 13/31 14/19 14/34 14/63 38 38/109 38/39 38/77 38/90 38/91 42 45 49 49/31 631/250/1619/554/1834 631/532/1542 631/67/1990/1673 631/67/327 64/60 Animals Apoptosis Biological evolution Bone marrow Bone remodeling CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Clonal Evolution - genetics Clonal Evolution - immunology Clonal selection Cloning Competitive advantage Datasets Evolution Failure Female Gene expression Hematopoietic stem cells Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Hematopoietic system Hemopoiesis Humanities and Social Sciences Humans Inflammation Inflammation - immunology Inflammation - pathology Leukemia Lymphocytes T Male Mice multidisciplinary Mutation Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - immunology Myelodysplastic Syndromes - pathology Neoplasms Pathogenesis Progenitor cells Science Science (multidisciplinary) Signal Transduction Stem Cell Niche - immunology Stem cells Stromal Cells Taxonomy
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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