CSAHi study: Detection of drug-induced ion channel/receptor responses, QT prolongation, and arrhythmia using multi-electrode arrays in combination with human induced pluripotent stem cell-derived cardiomyocytes

The use of multi-electrode arrays (MEA) in combination with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provides a promising method to predict comprehensive cardiotoxicity, including drug-induced QT prolongation and arrhythmia. We previously demonstrated that MEA in combin...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods Jg. 85; S. 73 - 81
Hauptverfasser:	Kitaguchi, Takashi, Moriyama, Yuta, Taniguchi, Tomohiko, Maeda, Sanae, Ando, Hiroyuki, Uda, Takaaki, Otabe, Koji, Oguchi, Masao, Shimizu, Shigekazu, Saito, Hiroyuki, Toratani, Atsushi, Asayama, Mahoko, Yamamoto, Wataru, Matsumoto, Emi, Saji, Daisuke, Ohnaka, Hiroki, Miyamoto, Norimasa
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.05.2017
Schlagworte:	action potentials arrhythmia Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - physiopathology calcium cardiomyocytes Cardiotonic Agents - pharmacology cardiotoxicity Cardiotoxins - pharmacology Cells, Cultured CSAHi Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Field potential fluoxetine guinea pigs Heart Rate - drug effects Heart Rate - physiology Human induced pluripotent stem cell-derived cardiomyocytes Humans Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - physiology ion channels Ion Channels - agonists Ion Channels - antagonists & inhibitors Ion Channels - physiology isoproterenols Methods Multi-electrode array muscles Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology ouabain pimozide Proarrhythmia QT prolongation quinidine Torsade de pointes toxicology TdP DMSO Ito ZD7288 (PubChem CID: 123983) FPDc FP Proarrhythmia hCQT IK1 IKs IKr Levcromakalim (PubChem CID: 93504) hESC-CMs hCTdP INa Torsade de pointes hERG Isoproterenol hydrochloride (PubChem CID: 5807) CSAHi (±)-Bay K8644 (PubChem CID: 2303) Ouabain octahydrate (PubChem CID: 122130920) MCEAD/TA MEA EAD IS TA BaCl2 dihydrate (PubChem CID: 5284346) Multi-electrode array Human induced pluripotent stem cell-derived cardiomyocytes ICH hCmax NS1643 (PubChem CID: 10177784) FPDc10 gpAPD Mibefradil dihydrochloride (PubChem CID: 60662) QT prolongation hiPSC-CMs Field potential FPD IKATP Methods BaCl dihydrate (PubChem CID: 5284346)
ISSN:	1056-8719, 1873-488X, 1873-488X
Online-Zugang:	Volltext
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