Tailed nuclei and dicentric chromosomes in irradiated subjects

A study of peripheral blood smears from irradiated Chernobyl liquidators and other subjects has shown nuclei of some lymphocytes to have a protrusion into the cytoplasm. Such abnormal nuclei are called “tailed” nuclei (TN). Sixteen main morphologic types, observed in human peripheral blood lymphocyt...

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Bibliographic Details
Published in:Applied radiation and isotopes Vol. 52; no. 5; pp. 1121 - 1127
Main Authors: Kravtsov, V.Yu, Fedortseva, R.F, Starkova, Ye.V, Yartseva, N.M, Nikiforov, A.M
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.05.2000
Subjects:
Adult
Aged
Cell Nucleus - radiation effects
Cell Nucleus - ultrastructure
Chromosome Aberrations
Chromosomes, Human - radiation effects
Chromosomes, Human - ultrastructure
Humans
Lymphocytes - radiation effects
Lymphocytes - ultrastructure
Male
Middle Aged
Radioactive Hazard Release
Ukraine
Ukraine
ISSN:0969-8043, 1872-9800
Online Access:Get full text
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Summary:A study of peripheral blood smears from irradiated Chernobyl liquidators and other subjects has shown nuclei of some lymphocytes to have a protrusion into the cytoplasm. Such abnormal nuclei are called “tailed” nuclei (TN). Sixteen main morphologic types, observed in human peripheral blood lymphocytes, are described. The frequency of appearance of lymphocytes with TN in a group of Chernobyl liquidators was significantly higher than in control groups ( p<0.001, in all cases). A positive correlation was found between the TN frequency in lymphocytes and dicentric chromosomes in lymphocytes cultured to metaphase ( p<0.001). Elevated frequencies of dicentrics, higher than 0.1%, were found in 17 out of 22 subjects in whom the frequency of lymphocytes with TN was 0.8% and more. Abnormalities of the TN type in lymphocytes are likely to result from breakdown of chromosome bridges formed by dicentrics. The TN can be considered as a possible marker of irradiation and, therefore, their detailed study is important.
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ISSN:0969-8043
1872-9800
DOI:10.1016/S0969-8043(00)00057-9