Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

The metalloproteases meprin alpha and beta are expressed in several tissues, leukocytes, and cancer cells. In skin, meprins are located in separate layers of human epidermis indicating distinct physiological functions, supported by effects on cultured keratinocytes. Meprin beta induces a dramatic ch...

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Vydané v:	Biological chemistry Ročník 391; číslo 4; s. 455
Hlavní autori:	Ohler, Anke, Debela, Mekdes, Wagner, Susanne, Magdolen, Viktor, Becker-Pauly, Christoph
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Germany 01.04.2010
Predmet:	Amino Acid Sequence Enzyme Activation Enzyme Precursors - metabolism Humans Kallikreins - metabolism Metalloendopeptidases - chemistry Metalloendopeptidases - metabolism Skin - enzymology Skin - metabolism Substrate Specificity
ISSN:	1437-4315, 1437-4315
On-line prístup:	Zistit podrobnosti o prístupe
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