Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation

The metalloproteases meprin alpha and beta are expressed in several tissues, leukocytes, and cancer cells. In skin, meprins are located in separate layers of human epidermis indicating distinct physiological functions, supported by effects on cultured keratinocytes. Meprin beta induces a dramatic ch...

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Bibliographic Details

Published in:	Biological chemistry Vol. 391; no. 4; p. 455
Main Authors:	Ohler, Anke, Debela, Mekdes, Wagner, Susanne, Magdolen, Viktor, Becker-Pauly, Christoph
Format:	Journal Article
Language:	English
Published:	Germany 01.04.2010
Subjects:	Amino Acid Sequence Enzyme Activation Enzyme Precursors - metabolism Humans Kallikreins - metabolism Metalloendopeptidases - chemistry Metalloendopeptidases - metabolism Skin - enzymology Skin - metabolism Substrate Specificity
ISSN:	1437-4315, 1437-4315
Online Access:	Get more information
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