Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle

Mitochondrial dysfunction, particularly affecting complex I of the respiratory chain, could play a fundamental role in the development of multiple organ failure during sepsis. Increasing electron flow through complex II by addition of succinate may improve mitochondrial oxygen utilization and thus a...

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Bibliographic Details

Published in:	Critical care medicine Vol. 35; no. 9; p. 2150
Main Authors:	Protti, Alessandro, Carré, Jane, Frost, Matthew T, Taylor, Valerie, Stidwill, Raymond, Rudiger, Alain, Singer, Mervyn
Format:	Journal Article
Language:	English
Published:	United States 01.09.2007
Subjects:	Animals Malates - pharmacology Male Mitochondria, Muscle - drug effects Mitochondria, Muscle - physiology Muscle, Skeletal - metabolism Oxygen Consumption - drug effects Peritonitis - metabolism Rats Rats, Wistar Sepsis - metabolism Succinates - pharmacology
ISSN:	0090-3493
Online Access:	Get more information
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