Tertiary lymphoid structures in cancer

Ectopic lymphoid aggregates, termed tertiary lymphoid structures (TLSs), are formed in numerous cancer types, and, with few exceptions, their presence is associated with superior prognosis and response to immunotherapy. In spite of their presumed importance, the triggers that lead to TLS formation i...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) Vol. 375; no. 6576; p. eabf9419
Main Authors: Schumacher, Ton N, Thommen, Daniela S
Format: Journal Article
Language:English
Published: United States 07.01.2022
Subjects:
Adaptive Immunity
Animals
Humans
Immune Checkpoint Inhibitors
Neoplasms - immunology
Neoplasms - pathology
Neoplasms - therapy
Prognosis
Tertiary Lymphoid Structures - immunology
Tertiary Lymphoid Structures - pathology
ISSN:1095-9203, 1095-9203
Online Access:Get more information
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Summary:Ectopic lymphoid aggregates, termed tertiary lymphoid structures (TLSs), are formed in numerous cancer types, and, with few exceptions, their presence is associated with superior prognosis and response to immunotherapy. In spite of their presumed importance, the triggers that lead to TLS formation in cancer tissue and the contribution of these structures to intratumoral immune responses remain incompletely understood. Here, we discuss the present knowledge on TLSs in cancer, focusing on (i) the drivers of TLS formation, (ii) the function and contribution of TLSs to the antitumor immune response, and (iii) the potential of TLSs as therapeutic targets in human cancers.
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.abf9419