Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish

Cardiac regeneration requires dedifferentiation and proliferation of mature cardiomyocytes, but the mechanisms underlying this plasticity remain unclear. Here, we identify a potent cardiomyogenic role for Krüppel-like factor 1 (Klf1/Eklf), which is induced in adult zebrafish myocardium upon injury....

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 372; no. 6538; p. 201
Main Authors:	Ogawa, Masahito, Geng, Fan-Suo, Humphreys, David T, Kristianto, Esther, Sheng, Delicia Z, Hui, Subhra P, Zhang, Yuxi, Sugimoto, Kotaro, Nakayama, Maki, Zheng, Dawei, Hesselson, Daniel, Hodson, Mark P, Bogdanovic, Ozren, Kikuchi, Kazu
Format:	Journal Article
Language:	English
Published:	United States 09.04.2021
Subjects:	Animals Cardiomegaly, Exercise-Induced Cell Dedifferentiation Cell Differentiation Cell Proliferation Cellular Reprogramming Gene Expression Regulation Gene Regulatory Networks Glycolysis Heart - embryology Heart - physiology Heart Ventricles - cytology Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Muscle Development Myocardium - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - physiology Pentose Phosphate Pathway Regeneration Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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