A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

The ability to control autoreactive T cells without inducing systemic immune suppression is the major goal for treatment of autoimmune diseases. The key challenge is the safe and efficient delivery of pharmaceutically well-defined antigens in a noninflammatory context. Here, we show that systemic de...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 371; H. 6525; S. 145
Hauptverfasser:	Krienke, Christina, Kolb, Laura, Diken, Elif, Streuber, Michael, Kirchhoff, Sarah, Bukur, Thomas, Akilli-Öztürk, Özlem, Kranz, Lena M, Berger, Hendrik, Petschenka, Jutta, Diken, Mustafa, Kreiter, Sebastian, Yogev, Nir, Waisman, Ari, Karikó, Katalin, Türeci, Özlem, Sahin, Ugur
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 08.01.2021
Schlagworte:	Animals Antigen-Presenting Cells Autoantigens - genetics Bystander Effect - immunology Encephalomyelitis, Autoimmune, Experimental - therapy Immunosuppression Therapy - methods Inflammation - immunology Mice Mice, Inbred C57BL mRNA Vaccines Multiple Sclerosis - therapy Pseudouridine - analogs & derivatives Pseudouridine - chemistry RNA, Messenger - adverse effects RNA, Messenger - chemistry RNA, Messenger - genetics T-Lymphocytes, Regulatory - immunology Vaccines, Synthetic - adverse effects Vaccines, Synthetic - therapeutic use
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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