Alleviation of fibrosis and oxidative stress in pressure overload-induced cardiac remodeling and heart failure via SIRT3 activation by colchicine

Heart failure (HF) is the end stage of many cardiovascular diseases, which is often associated with myocardial hypertrophy and cardiac remodeling. Among them, pressure overload-induced myocardial injury is one of the most common causes of heart failure. Colchicine, a drug widely used in the treatmen...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 770; p. 151957
Main Authors:	Wu, Mengze, Chen, Guodong, Peng, Yuce, Luo, Suxin
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 12.07.2025
Subjects:	agonists Animals atrial fibrillation Colchicine Colchicine - pharmacology Colchicine - therapeutic use coronary artery disease drugs fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Fibrosis Heart failure Heart Failure - drug therapy Heart Failure - metabolism Heart Failure - pathology hypertrophy Male Mice Mice, Inbred C57BL Myocardium - metabolism Myocardium - pathology Oxidative stress Oxidative Stress - drug effects risk reduction simulation models SIRT3 Sirtuin 3 - metabolism therapeutics Ventricular Remodeling - drug effects Heart failure Oxidative stress Colchicine Fibrosis SIRT3
ISSN:	0006-291X, 1090-2104, 1090-2104
Online Access:	Get full text
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