Association Between Increased Linezolid Plasma Concentrations and the Development of Severe Toxicity in Multidrug-Resistant Tuberculosis Treatment

Treatment of multidrug-resistant (MDR) tuberculosis with linezolid is characterized by high rates of adverse events. Evidence on therapeutic drug monitoring to predict drug toxicity is scarce. This study aimed to evaluate the association of linezolid trough concentrations with severe toxicity. We re...

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Veröffentlicht in:	Clinical infectious diseases Jg. 76; H. 3; S. e947
Hauptverfasser:	Eimer, Johannes, Fréchet-Jachym, Mathilde, Le Dû, Damien, Caumes, Eric, El-Helali, Najoua, Marigot-Outtandy, Dhiba, Mechai, Frédéric, Peytavin, Gilles, Pourcher, Valérie, Rioux, Christophe, Yazdanpanah, Yazdan, Robert, Jérôme, Guglielmetti, Lorenzo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 08.02.2023
Schlagworte:	Antitubercular Agents - adverse effects Drug Monitoring Humans Linezolid - adverse effects Retrospective Studies Tuberculosis, Multidrug-Resistant - drug therapy toxicity severe adverse events linezolid multidrug-resistant tuberculosis therapeutic drug monitoring
ISSN:	1537-6591, 1537-6591
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