Chronic immune activation in the T cell compartment of HCV/HIV-1 co-infected patients

Activation of innate and adaptive immune mechanisms in response to infection is necessary to control and clear infections. However, chronic immune activation in human immunodeficiency virus 1 (HIV-1) infection has a series of detrimental effects and is a major driving force in HIV-1 disease progress...

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Vydané v:	Virulence Ročník 1; číslo 3; s. 177 - 179
Hlavní autori:	Sandberg, Johan K., Falconer, Karolin, Gonzalez, Veronica D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Taylor & Francis 01.05.2010
Predmet:	ADP-ribosyl Cyclase 1 - metabolism Antiretroviral Therapy, Highly Active Antiviral Agents - therapeutic use Binding Biology Bioscience Calcium Cancer CD8-Positive T-Lymphocytes - immunology Cell Cycle Disease Progression Drug Therapy, Combination Hepacivirus - immunology Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - immunology Hepatitis C, Chronic - virology HIV Infections - complications HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - immunology Humans Interferon-alpha - therapeutic use Landes Lymphocyte Activation - immunology Membrane Glycoproteins - metabolism Organogenesis Polyethylene Glycols - therapeutic use Proteins Ribavirin - therapeutic use T-Lymphocytes - immunology
ISSN:	2150-5594, 2150-5608, 2150-5608
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Popis
Shrnutí:	Activation of innate and adaptive immune mechanisms in response to infection is necessary to control and clear infections. However, chronic immune activation in human immunodeficiency virus 1 (HIV-1) infection has a series of detrimental effects and is a major driving force in HIV-1 disease progression. We recently found that patients with chronic hepatitis C virus (HCV)/HIV-1 co-infection display sharply elevated immune activation as determined by expression of CD38 in T cells. High immune activation was observed despite that these patients were on effective antiretroviral therapy (ART), which usually brings down activation levels in HIV-infected people. HCV treatment with pegylated interferon-α (IFNα) and ribavirin reduced activation, and this was at first glance unexpected as IFNα is believed to be involved in driving activation. Here, we briefly summarize these findings and discuss them in context of the emerging roles of the gut barrier and the liver in chronic immune activation and viral disease progression.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2150-5594 2150-5608 2150-5608
DOI:	10.4161/viru.1.3.11206