Improved kinetic parameter estimation in pH-profile data treatment

Statistical problems in temperature stability parameter estimation have been the subject of many papers whereas statistics in, pH-profile parameter estimation have focused little attention. However, the conventional two step method used in data treatment in both cases leads to identical statistical...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 198; no. 1; pp. 39 - 49
Main Authors:	Some, Issa T, Bogaerts, Philippe, Hanus, Raymond, Hanocq, Michel, Dubois, Jacques
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 30.03.2000 Elsevier
Subjects:	Acetylsalicylic acid Algorithms Aspirin - chemistry Biological and medical sciences Chromatography, High Pressure Liquid Costs and Cost Analysis Data Interpretation, Statistical Drug Stability General pharmacology Hydrogen-Ion Concentration Kinetics Markov Chains Medical sciences Non-linear fitting Nonlinear Dynamics pH-profile Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Simplex algorithm Stability pH-profile Stability Acetylsalicylic acid Simplex algorithm Non-linear fitting Salicylic acid Pharmaceutical technology Mathematical analysis Estimation Chemical stability pH Kinetic parameter Chemical properties Salicylates Forecast model Chemical reaction kinetics Physicochemical properties
ISSN:	0378-5173, 1873-3476
Online Access:	Get full text
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