Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities

Brief Report: Zika Virus Infection and Fetal Brain Abnormalities In this case report, the association between Zika virus infection and teratogenicity is strengthened, with evidence that the latency period between ZIKV infection of the fetal brain and the detection of microcephaly and intracranial ca...

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Vydáno v:The New England journal of medicine Ročník 374; číslo 22; s. 2142 - 2151
Hlavní autoři: Driggers, Rita W, Ho, Cheng-Ying, Korhonen, Essi M, Kuivanen, Suvi, Jääskeläinen, Anne J, Smura, Teemu, Rosenberg, Avi, Hill, D. Ashley, DeBiasi, Roberta L, Vezina, Gilbert, Timofeev, Julia, Rodriguez, Fausto J, Levanov, Lev, Razak, Jennifer, Iyengar, Preetha, Hennenfent, Andrew, Kennedy, Richard, Lanciotti, Robert, du Plessis, Adre, Vapalahti, Olli
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Massachusetts Medical Society 02.06.2016
Edice:Brief Report
Témata:
Adult
Birth defects
Brain
Brain - abnormalities
Brain - embryology
Brain - pathology
Brain - virology
Cortex
Disease Outbreaks
Female
Fetus - abnormalities
Fetuses
Gestation
Humans
Magnetic Resonance Imaging
Maternal & child health
Microcephaly
Microcephaly - virology
Microencephaly
Neuroimaging
Outbreaks
Pregnancy
Pregnancy Complications, Infectious - virology
Ribonucleic acid
RNA
Ultrasonography, Prenatal
Ultrasound
Viral infections
Viremia
Zika virus
Zika Virus - isolation & purification
Zika Virus Infection - complications
Zika Virus Infection - epidemiology
Guatemala
ISSN:0028-4793, 1533-4406
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Shrnutí:Brief Report: Zika Virus Infection and Fetal Brain Abnormalities In this case report, the association between Zika virus infection and teratogenicity is strengthened, with evidence that the latency period between ZIKV infection of the fetal brain and the detection of microcephaly and intracranial calcifications on ultrasonography may be prolonged. Zika virus (ZIKV), a mosquito-borne flavivirus and member of the Flaviviridae family, was originally isolated from a sentinel primate in Uganda in 1947. 1 ZIKV was associated with mild febrile disease and maculopapular rash in tropical Africa and some areas of Southeast Asia. Since 2007, ZIKV has caused several outbreaks outside its former distribution area in islands of the Pacific: in 2007 on Yap island in Micronesia, in 2013 and 2014 in French Polynesia, and in 2015 in South America, where ZIKV had not been identified previously. 2 – 5 There are separate African and Asian lineages of the virus, 6 and the latter . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa1601824